Paper · 41003497

Modification of Closed-State Inactivation in Voltage-Gated Sodium Channel Nav1.7 by Two Novel Arachnid Toxins.

Johnson JW and 2 others. Toxins (Basel), 2025. Cited by 0 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Modification of Closed-State Inactivation in Voltage-Gated Sodium Channel Nav1.7 by Two Novel Arachnid Toxins. Papers, record 41003497. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/41003497

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Modification of Closed-State Inactivation in Voltage-Gated Sodium Channel Nav1.7 by Two Novel Arachnid Toxins.; PubMed
Journal: Toxins (Basel); PubMed
Year: 2025; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/41003497/; PubMed
DOI: https://doi.org/10.3390/toxins17090432; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12473925/; PubMed
The journal: https://conductscience.org/library/journal-index/101530765; PubMed
Citations, by iCite: 0; iCite
Revised in PubMed: 2025-09-28; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Johnson JW	John W
2	Rikli HG	Hillary G
3	Johnson SR	Stephen R	https://orcid.org/0000-0002-7025-4933

Source PubMed

Topics6

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
NAV1.7 Voltage-Gated Sodium Channel	Major topic
Spider Venoms	Major topic
Arthropod Venoms	Major topic
Animals
Humans
Xenopus laevis

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References68

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	15,683,238	A spider toxin that induces a typical effect of scorpion alpha-toxins but competes with beta-toxins on binding to insect sodium channels.	Biochemistry	2005	https://conductscience.org/library/papers/15683238	PubMed
2	22,160,714	Structural basis for gating charge movement in the voltage sensor of a sodium channel.	Proc Natl Acad Sci U S A	2012	https://conductscience.org/library/papers/22160714	PubMed
3	23,055,474	The Hodgkin-Huxley heritage: from channels to circuits.	J Neurosci	2012	https://conductscience.org/library/papers/23055474	PubMed
4	26,921,461	Isolation, chemical and functional characterization of several new K(+)-channel blocking peptides from the venom of the scorpion Centruroides tecomanus.	Toxicon	2016	https://conductscience.org/library/papers/26921461	PubMed
5	12,843,211	Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons.	J Physiol	2003	https://conductscience.org/library/papers/12843211	PubMed
6	25,088,688	From foe to friend: using animal toxins to investigate ion channel function.	J Mol Biol	2015	https://conductscience.org/library/papers/25088688	PubMed
7	20,585,544	Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study.	PLoS Comput Biol	2010	https://conductscience.org/library/papers/20585544	PubMed
8	6,327,148	Inactivation of open and closed sodium channels determined separately.	Cold Spring Harb Symp Quant Biol	1983	https://conductscience.org/library/papers/6327148	PubMed
9	2,427,018	Molecular properties of voltage-sensitive sodium channels.	Annu Rev Biochem	1986	https://conductscience.org/library/papers/2427018	PubMed
10	10,798,388	From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.	Neuron	2000	https://conductscience.org/library/papers/10798388	PubMed

1 to 10 of 68

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Cited by0

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 0 citations.

None in this release.

Genes5

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
MAPT	4,137	PubTator's text mining	https://conductscience.org/library/genes/4137	NCBI Gene
SCN10A	6,336	PubTator's text mining	https://conductscience.org/library/genes/6336	NCBI Gene
SCN4A	6,329	PubTator's text mining	https://conductscience.org/library/genes/6329	NCBI Gene
SCN5A	6,331	PubTator's text mining	https://conductscience.org/library/genes/6331	NCBI Gene
SCN9A	6,335	PubTator's text mining	https://conductscience.org/library/genes/6335	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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