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Gene · 6335

SCN9A: sodium voltage-gated channel alpha subunit 9

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCN9A: sodium voltage-gated channel alpha subunit 9. Genes, record 6335. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6335

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Gene

Symbol
SCN9A
HGNC
Name
sodium voltage-gated channel alpha subunit 9
HGNC
NCBI Gene ID
6335
NCBI Gene
HGNC ID
HGNC:10597
HGNC
Ensembl
ENSG00000169432
NCBI Gene
Aliases
ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA, Nav1.7, PN1, SFNP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15858Sodium channel protein type 9 subunit alpha1,98843Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026517682 A2026-06-021Q15858Espacenet
EP 4698233 A22026-02-251Q15858Espacenet
JP 2026004568 A2026-01-1463910Q15858Espacenet
EP 4641201 A22025-10-293845Q15858Espacenet
JP 2025529142 A2025-09-043851Q15858Espacenet
US 12371689 B22025-07-293851Q15858Espacenet
JP 2025517969 A2025-06-123845Q15858Espacenet
JP 2025032204 A2025-03-1135309Q15858Espacenet
JP 2025032204 A2025-03-1135312Q15858Espacenet
EP 4461818 A22024-11-1335309Q15858Espacenet

1 to 10 of 50

See all 50 patents

Drugs90

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
AZD3161CHEMBL3545208Sodium channel protein type IX alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINECHEMBL370805Sodium channel alpha subunit blockerBLOCKERChEMBL

1 to 10 of 90

See all 90 drugs

Trials1,313

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,318

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCN9A papersNewest fiscal year
UL1TR001863Yale Clinical and Translational Science Award192025
R01NS034509Functional Genetics of the Neuronal Sodium Channel Gene SCN8A92025
R35NS105076Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain82025
I50RX002999Center for Restoration of Nervous System Function72025
R01AR060364Molecular Pathways of Pain Generation in Osteoarthritis52025
R01HL112808Structural Basis for Antiarrhythmic Drug Action52025
R01NS045594Study of Activity-Dependent Sympathetic Sprouting52025
U19NS130608Human Nociceptor and Spinal Cord Molecular Signature Center52025
UL1TR002345Washington University Institute of Clinical and Translational Sciences52025
P30CA008748Cancer Center Support Grant42025

1 to 10 of 1,318Source NIH's project files

See all 1,318 nih grants

Papers3,231

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Establishment of a human pluripotent stem cell-derived sensory neuron platform for studying diabetes-associated metabolic and oxidative stress-induced neuronal injury.J Neurosci Methods202742826868PubTator, text miningPubMed
Discovery and Characterization of Neuroactive Secondary Metabolites from Acacia sieberiana with Potential Analgesic Properties.ACS Omega202642819829PubTator, text miningPubMed
Peripheral NaV1.7 modulation reveals divergent peripheral and central adaptations in persistent trigeminal pain.bioRxiv202642818013PubTator, text miningPubMed
Chasing the Wrong Door for 30 Years: Is Suzetrigine the Key to Selective Pain Relief?Medicina (Kaunas)202642796305PubTator, text miningPubMed
Pharmacological modulation of peripheral nerve excitability: a novel way to investigate sodium channel subtypes in humans.Pain202642751727PubTator, text miningPubMed
Deeper delving Nav1.8 inhibitor Suzetrigine in chronic pain.Acta Pharmacol Sin202642745014PubTator, text miningPubMed
Investigating genetic susceptibility to concussion through rare variants in ion channel and neurotransmission genes.J Neurol202642730919PubTator, text miningPubMed
Ion-Channel Activity of Characteristic Alkaloids From Uncaria rhynchophylla.Chem Biodivers202642720106PubTator, text miningPubMed
Antigen-Detected NMR for Minimal Epitope Engineering and Structure-Guided Selection of a NaV1.7-Selective Nanobody.Adv Sci (Weinh)202642702812PubTator, text miningPubMed
Pain Management in Erythromelalgia: A Systematic Review and Graded Appraisal Across Etiological Subtypes.Eur J Pain202642695143PubTator, text miningPubMed

1 to 10 of 3,231

See all 3,231 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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