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Gene · 6336

SCN10A: sodium voltage-gated channel alpha subunit 10

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SCN10A: sodium voltage-gated channel alpha subunit 10. Genes, record 6336. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/6336

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Gene

Symbol
SCN10A
HGNC
Name
sodium voltage-gated channel alpha subunit 10
HGNC
NCBI Gene ID
6336
NCBI Gene
HGNC ID
HGNC:10582
HGNC
Ensembl
ENSG00000185313
NCBI Gene
Aliases
FEPS2, Nav1.8, PN3, SNS, hPN3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y5Y9Sodium channel protein type 10 subunit alpha1,9568Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463929Q9Y5Y9Espacenet
US 12516308 B22026-01-062436Q9Y5Y9Espacenet
EP 4640849 A22025-10-292019Q9Y5Y9Espacenet
EP 4641201 A22025-10-2913534Q9Y5Y9Espacenet
JP 2025529142 A2025-09-043838Q9Y5Y9Espacenet
US 12371689 B22025-07-293838Q9Y5Y9Espacenet
JP 2025519096 A2025-06-242019Q9Y5Y9Espacenet
JP 2025517969 A2025-06-1213534Q9Y5Y9Espacenet
JP 2024520478 A2024-05-2435Q9Y5Y9Espacenet
US 11898179 B22024-02-132436Q9Y5Y9Espacenet

1 to 10 of 31

See all 31 patents

Drugs88

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AFACIFENACINCHEMBL3545165Sodium channel protein type X alpha subunit blockerBLOCKERChEMBL
ARTICAINECHEMBL1093Sodium channel alpha subunit blockerBLOCKERChEMBL
ARTICAINE HYDROCHLORIDECHEMBL1200819Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATECHEMBL1200Sodium channel alpha subunit blockerBLOCKERChEMBL
BENOXINATE HYDROCHLORIDECHEMBL1200654Sodium channel alpha subunit blockerBLOCKERChEMBL
CARBAMAZEPINECHEMBL108Sodium channel alpha subunit blockerBLOCKERChEMBL
CENOBAMATECHEMBL3989949Sodium channel alpha subunit inhibitorINHIBITORChEMBL
CHLOROPROCAINECHEMBL1179047Sodium channel alpha subunit blockerBLOCKERChEMBL
CHLOROPROCAINE HYDROCHLORIDECHEMBL944Sodium channel alpha subunit blockerBLOCKERChEMBL
COCAINECHEMBL370805Sodium channel alpha subunit blockerBLOCKERChEMBL

1 to 10 of 88

See all 88 drugs

Trials1,302

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,551

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSCN10A papersNewest fiscal year
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL202025
P30DK063491Diabetes Research Center (DRC)152025
UL1TR001863Yale Clinical and Translational Science Award142025
R01AR060364Molecular Pathways of Pain Generation in Osteoarthritis102025
R01AR064251Osteoarthritis Progression And Sensory Pathway Alterations102025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal102025
ZIAAG007380CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective study92025
R35NS105076Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain62025
UL1TR001881UCLA Clinical and Translational Science Institute62025
R01AR077019The Role of Mechanosensation Pathways in Osteoarthritis Joint Damage and Pain52025

1 to 10 of 1,551Source NIH's project files

See all 1,551 nih grants

Papers2,467

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Suzetrigine: A Selective Inhibitor of the NaV1.8 Sodium Channel.Cureus202642807747PubTator, text miningPubMed
Chasing the Wrong Door for 30 Years: Is Suzetrigine the Key to Selective Pain Relief?Medicina (Kaunas)202642796305PubTator, text miningPubMed
Suzetrigine for Postoperative Pain in Head and Neck Free Flap or Transoral Robotic Surgery.JAMA Otolaryngol Head Neck Surg202642752794PubTator, text miningPubMed
Deeper delving Nav1.8 inhibitor Suzetrigine in chronic pain.Acta Pharmacol Sin202642745014PubTator, text miningPubMed
First-in-Human Phase I Trial of HRS-2129, a Selective Nav1.8 Inhibitor: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects.Drug Des Devel Ther202642712963PubTator, text miningPubMed
Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics.J Clin Invest202642709487PubTator, text miningPubMed
A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective inhibition.Cell Chem Biol202642679814PubTator, text miningPubMed
Human α1-Antitrypsin Inhibits Nociceptor Excitability and Relieves Inflammatory and Neuropathic Pain.Biomolecules202642650742PubTator, text miningPubMed
Suzetrigine (Journavx) for Acute Dental Pain: First Clinical Case Series of a Selective Naᵥ1.8 Inhibitor in Endodontics.J Endod202642641947PubTator, text miningPubMed
Safinamide dual molecular mechanisms: sodium channel and glutamate modulation as a translational rationale for neuropathic pain - A narrative review.Drug Metab Pers Ther202642639659PubTator, text miningPubMed

1 to 10 of 2,467

See all 2,467 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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