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Paper · 8726014

Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA.

Frothingham R and 4 others. Antimicrob Agents Chemother, 1996. Cited by 23 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA. Papers, record 8726014. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8726014

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA.
PubMed
Journal
Antimicrob Agents Chemother
PubMed
Year
1996
PubMed
Publication types
Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
23
iCite
Relative citation ratio, by iCite
0.7
iCite
Revised in PubMed
2020-07-24
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Frothingham RR
2Meeker-O'Connell WAW A
3Talbot EAE A
4George JWJ W
5Kreuzer KNK N

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AmidohydrolasesMajor topic
Escherichia coliMajor topic
Gene Expression Regulation, EnzymologicMajor topic
NicotinamidaseMajor topic
Amino Acid Sequence
Base Sequence
DNA Primers
DNA Transposable Elements
Molecular Sequence Data
Mycobacterium
Phenotype

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
AI07392NIAID NIH HHSUnited StatesPubMedPubMed
AI35230NIAID NIH HHSUnited StatesR01AI035230PubMed and NIHNIH RePORTER
R29AI035230NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References35

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,203,284Simple pyrazinamidase and urease tests for routine identification of mycobacteria.Am Rev Respir Dis1974https://conductscience.org/library/papers/4203284PubMed
28,350,889Treatment of multidrug-resistant tuberculosis.N Engl J Med1993https://conductscience.org/library/papers/8350889PubMed
38,376,822Catalase-peroxidase gene sequences in isoniazid-sensitive and -resistant strains of Mycobacterium tuberculosis from New York City.J Infect Dis1993https://conductscience.org/library/papers/8376822PubMed
48,257,122Direct, automated detection of rifampin-resistant Mycobacterium tuberculosis by polymerase chain reaction and single-strand conformation polymorphism analysis.Antimicrob Agents Chemother1993https://conductscience.org/library/papers/8257122PubMed
58,132,154Amplification and nucleotide sequence of the quinolone resistance-determining region in the gyrA gene of mycobacteria.FEMS Microbiol Lett1994https://conductscience.org/library/papers/8132154PubMed
68,169,415Mutations in the catalase-peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates.J Infect Dis1994https://conductscience.org/library/papers/8169415PubMed
78,035,042Selection of a gyrA mutant of Mycobacterium tuberculosis resistant to fluoroquinolones during treatment with ofloxacin.J Infect Dis1994https://conductscience.org/library/papers/8035042PubMed
87,929,750Extensive DNA sequence conservation throughout the Mycobacterium tuberculosis complex.J Clin Microbiol1994https://conductscience.org/library/papers/7929750PubMed
97,840,574Characterization of rifampin-resistance in pathogenic mycobacteria.Antimicrob Agents Chemother1994https://conductscience.org/library/papers/7840574PubMed
107,494,049Testing of susceptibility of Mycobacterium tuberculosis to pyrazinamide: comparison of Bactec method with pyrazinamidase assay.J Clin Microbiol1995https://conductscience.org/library/papers/7494049PubMed

1 to 10 of 35

See all 35 references

Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 23 citations.

PMIDTitleJournalYearIn PapersSource
32,010,617Role of Sirtuins in Tumor Angiogenesis.Front Oncol2019https://conductscience.org/library/papers/32010617PubMed
29,425,231Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841.PLoS One2018https://conductscience.org/library/papers/29425231PubMed
28,455,340Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis.Appl Environ Microbiol2017https://conductscience.org/library/papers/28455340PubMed
28,018,295Combined Whole-Cell High-Throughput Functional Screening for Identification of New Nicotinamidases/Pyrazinamidases in Metagenomic/Polygenomic Libraries.Front Microbiol2016https://conductscience.org/library/papers/28018295PubMed
27,451,449The Riemerella anatipestifer AS87_01735 Gene Encodes Nicotinamidase PncA, an Important Virulence Factor.Appl Environ Microbiol2016https://conductscience.org/library/papers/27451449PubMed
26,443,758Biogenesis and Homeostasis of Nicotinamide Adenine Dinucleotide Cofactor.EcoSal Plus2009https://conductscience.org/library/papers/26443758PubMed
21,778,210Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA.Microbiology (Reading)2011https://conductscience.org/library/papers/21778210PubMed
20,709,892Elucidation of beta-oxidation pathways in Ralstonia eutropha H16 by examination of global gene expression.J Bacteriol2010https://conductscience.org/library/papers/20709892PubMed
20,007,326The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.Endocr Rev2010https://conductscience.org/library/papers/20007326PubMed
19,138,656Redox responses in yeast to acetate as the carbon source.Arch Biochem Biophys2009https://conductscience.org/library/papers/19138656PubMed

1 to 10 of 13

See all 13 cited by

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data7

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccessionSource
GENBANKL42023GENBANK
GENBANKM26934GENBANK
GENBANKP21367GENBANK
GENBANKP21369GENBANK
GENBANKP32400GENBANK
GENBANKP37347GENBANK
GENBANKP37532GENBANK

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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