Paper · 87485

Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state.

Waters CA and 3 others. J Exp Med, 1979. Cited by 49 papers, by iCite.

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ConductScience Library. Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state. Papers, record 87485. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/87485

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state.; PubMed
Journal: J Exp Med; PubMed
Year: 1979; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/87485/; PubMed
DOI: https://doi.org/10.1084/jem.149.5.1134; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC2184860/; PubMed
The journal: https://conductscience.org/library/journal-index/2985109R; PubMed
Citations, by iCite: 49; iCite
Relative citation ratio, by iCite: 1.15; iCite
Revised in PubMed: 2021-12-03; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Waters CA	C A
2	Pilarski LM	L M
3	Wegmann TG	T G
4	Diener E	E

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
B-Lymphocytes	Major topic
Fetus	Major topic
Immune Tolerance	Major topic
T-Lymphocytes	Major topic
gamma-Globulins	Major topic
Animals
Female
Humans
Immunosuppression Therapy
Mice
Mice, Inbred BALB C
Pregnancy
Time Factors

Source PubMed

Grants0

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None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References43

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	1,084,409	Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.	J Exp Med	1976	https://conductscience.org/library/papers/1084409	PubMed
2	1,101,472	The role of specific suppressor T cells in immune tolerance.	Transplant Rev	1975	https://conductscience.org/library/papers/1101472	PubMed
3	1,103,386	Regulation of immunoglobulin and antibody production by allotype suppressor T cells in mice.	Transplant Rev	1975	https://conductscience.org/library/papers/1103386	PubMed
4	1,162,355	Immunological tolerance: transmission from mother to offspring.	Science	1975	https://conductscience.org/library/papers/1162355	PubMed
5	1,236,887	Decreased antibody response in the offspring of immunized high responder rats.	J Immunol	1975	https://conductscience.org/library/papers/1236887	PubMed
6	13,668,512	Genes and antibodies.	Science	1959	https://conductscience.org/library/papers/13668512	PubMed
7	14,097,352	THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.	Biochem J	1963	https://conductscience.org/library/papers/14097352	PubMed
8	150,333	Neonatally induced transplantation tolerance: in vitro evidence supporting a clonal inactivation mechanism.	Eur J Immunol	1975	https://conductscience.org/library/papers/150333	PubMed
9	303,254	Cellular events in tolerance. VI. Neonatal vs adult B cell tolerance: differences in antigen-binding cell patterns and lipopolysaccharide stimulation.	J Immunol	1977	https://conductscience.org/library/papers/303254	PubMed
10	303,688	B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells.	J Exp Med	1977	https://conductscience.org/library/papers/303688	PubMed

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Cited by13

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 49 citations.

PMID	Title	Journal	Year	In Papers	Source
12,699,406	Impaired CD40-signalling in Langerhans' cells from murine neonatal draining lymph nodes: implications for neonatally induced cutaneous tolerance.	Clin Exp Immunol	2003	https://conductscience.org/library/papers/12699406	PubMed
8,666,919	Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity.	J Exp Med	1996	https://conductscience.org/library/papers/8666919	PubMed
6,968,812	Relative sensitivity of fetal and newborn mice to induction of hapten-specific B cell tolerance.	J Exp Med	1980	https://conductscience.org/library/papers/6968812	PubMed
6,966,401	Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen.	Proc Natl Acad Sci U S A	1980	https://conductscience.org/library/papers/6966401	PubMed
6,808,076	A natural model of immunologic tolerance. Tolerance to murine C5 is mediated by T cells, and antigen is required to maintain unresponsiveness.	J Exp Med	1982	https://conductscience.org/library/papers/6808076	PubMed
6,804,951	Clonal anergy: the universally anergic B lymphocyte.	Proc Natl Acad Sci U S A	1982	https://conductscience.org/library/papers/6804951	PubMed
6,446,426	Current perspectives on the cellular mechanisms of immunologic tolerance.	Clin Exp Immunol	1980	https://conductscience.org/library/papers/6446426	PubMed
6,417,259	Tolerance for self IG at the level of the Ly1+ T cell.	J Exp Med	1983	https://conductscience.org/library/papers/6417259	PubMed
6,332,828	Severe deficiency of B lymphocytes in peripheral blood from multiple myeloma patients.	J Clin Invest	1984	https://conductscience.org/library/papers/6332828	PubMed
6,187,882	Suppressor T cell memory. II. The role of memory suppressor T cells in tolerance to human gamma globulin.	J Exp Med	1983	https://conductscience.org/library/papers/6187882	PubMed

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Genes0

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None in this release.

Drugs0

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None in this release.

Data0

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Data dates

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PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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