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Paper8778

Dual role of Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat liver.

Tejwani GA and 3 others. Proc Natl Acad Sci U S A, 1976. Cited by 60 papers, by iCite.

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ConductScience Library. Dual role of Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat liver. Papers, record 8778. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8778

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Dual role of Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat liver.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1976
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
60
iCite
Relative citation ratio, by iCite
2.1
iCite
Revised in PubMed
2019-05-01
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Tejwani GAG A
2Pedrosa FOF O
3Pontremoli SS
4Horecker BLB L

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Fructose-BisphosphataseMajor topic
LiverMajor topic
ZincMajor topic
Animals
Binding Sites
Cobalt
Edetic Acid
Histidine
Hydrogen-Ion Concentration
Kinetics
Magnesium
Rats

Source PubMed

References16

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
114,342,513SOME PROPERTIES OF FRUCTOSE 1,6-DIPHOSPHATASE OF RAT LIVER AND THEIR RELATION TO THE CONTROL OF GLUCONEOGENESIS.Biochem J1965https://conductscience.org/library/papers/14342513PubMed
214,346,089FRUCTOSE 1, 6-DIPHOSPHATASE IN STRIATED MUSCLE.Biochem J1965https://conductscience.org/library/papers/14346089PubMed
3239,683The purification of fructose 1,6-diphosphatase from ox liver and its activation by ethylenediaminetetra-acetate.Biochem J1975https://conductscience.org/library/papers/239683PubMed
44,144,054Activation of rabbit kidney fructose diphosphatase by Mg-EDTA, Mn-EDTA and Co-EDTA complexes.Arch Biochem Biophys1973https://conductscience.org/library/papers/4144054PubMed
54,216,302The activation of rabbit muscle, liver, and kidney fructose bisphosphatases by histidine and citrate.Arch Biochem Biophys1974https://conductscience.org/library/papers/4216302PubMed
64,284,291Fructose diphosphatase from rabbit liver. I. Purification and properties.J Biol Chem1965https://conductscience.org/library/papers/4284291PubMed
74,286,494Purification and properties of a specific fructose 1,6-diphosphatase from Candida utilis.Arch Biochem Biophys1965https://conductscience.org/library/papers/4286494PubMed
84,296,683Natural activators for liver fructose 1,6-diphosphatase and the reversal of adenosine 5'-monophosphate inhibition by muscle phosphofructokinase.J Biol Chem1968https://conductscience.org/library/papers/4296683PubMed
94,332,726Activation of fructose diphosphatase by manganese, magnesium and cobalt.Arch Biochem Biophys1971https://conductscience.org/library/papers/4332726PubMed
104,335,960Rabbit liver fructose 1,6-diphosphatase. Properties of the native enzyme and their modification by subtilisin.Arch Biochem Biophys1972https://conductscience.org/library/papers/4335960PubMed
114,339,937Activation of rabbit muscle fructose diphosphatase by EDTA and the effect of divalent cations.Arch Biochem Biophys1972https://conductscience.org/library/papers/4339937PubMed
124,346,346Activation of muscle fructose 1,6-diphosphatase by creatine phosphate and citrate.J Biol Chem1973https://conductscience.org/library/papers/4346346PubMed
134,366,754Regulation of fructose, 1,6-bisphosphatase by histidine under gluconeogenic conditions.Proc Natl Acad Sci U S A1974https://conductscience.org/library/papers/4366754PubMed
145,418Control of rabbit liver fructose-1, 6-diphosphatase activity by magnesium ions.J Biochem1975https://conductscience.org/library/papers/5418PubMed
155,768,868Binding of diffusible molecules by macromolecules: rapid measurement by rate of dialysis.J Biol Chem1969https://conductscience.org/library/papers/5768868PubMed
165,970,965A new micromethod for the colorimetric determination of inorganic phosphate.Clin Chim Acta1966https://conductscience.org/library/papers/5970965PubMed

Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 60 citations.

PMIDTitleJournalYearIn PapersSource
36,249,403Zn2+-Induced Conformational Change Affects the SAM Binding in a Mycobacterial SAM-Dependent Methyltransferase.ACS Omega2022https://conductscience.org/library/papers/36249403PubMed
33,946,543Cobalt Regulates Activation of Camk2α in Neurons by Influencing Fructose 1,6-bisphosphatase 2 Quaternary Structure and Subcellular Localization.Int J Mol Sci2021https://conductscience.org/library/papers/33946543PubMed
29,490,098The Multiple Faces of the Metal Transporter ZIP14 (SLC39A14).J Nutr2018https://conductscience.org/library/papers/29490098PubMed
26,425,391Carnosine and Related Peptides: Therapeutic Potential in Age-Related Disorders.Aging Dis2015https://conductscience.org/library/papers/26425391PubMed
10,051,573Inhibitory sites in enzymes: zinc removal and reactivation by thionein.Proc Natl Acad Sci U S A1999https://conductscience.org/library/papers/10051573PubMed
744,559Secondary metabolism: regulation by phosphate and trace elements.Folia Microbiol (Praha)1978https://conductscience.org/library/papers/744559PubMed
209,458Binding and kinetic data for rabbit liver fructose-1,6-bisphosphatase with Zn2+ as cofactor.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/209458PubMed
200,922In vivo and in vitro phosphorylation of rat liver fructose-1,6-bisphosphatase.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/200922PubMed
197,519Binding of Zn2+ to rat liver fructose-1,6-bisphosphatase and its effect on the catalytic properties.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/197519PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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