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Paper200922

In vivo and in vitro phosphorylation of rat liver fructose-1,6-bisphosphatase.

Riou JP and 4 others. Proc Natl Acad Sci U S A, 1977. Cited by 130 papers, by iCite.

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ConductScience Library. In vivo and in vitro phosphorylation of rat liver fructose-1,6-bisphosphatase. Papers, record 200922. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/200922

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
In vivo and in vitro phosphorylation of rat liver fructose-1,6-bisphosphatase.
PubMed
Journal
Proc Natl Acad Sci U S A
PubMed
Year
1977
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
130
iCite
Relative citation ratio, by iCite
4.12
iCite
Revised in PubMed
2019-05-01
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Riou JPJ P
2Claus THT H
3Flockhart DAD A
4Corbin JDJ D
5Pilkis SJS J

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Fructose-BisphosphataseMajor topic
LiverMajor topic
Animals
Cattle
Cyclic AMP
Electrophoresis, Polyacrylamide Gel
In Vitro Techniques
Phosphates
Phosphorus Radioisotopes
Precipitin Tests
Protein Kinases
Rats
Serine

Source PubMed

References21

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
2187,597Hormonal control of [14C]glucose synthesis from [U-14C]dihydroxyacetone and glycerol in isolated rat hepatocytes.J Biol Chem1976https://conductscience.org/library/papers/187597PubMed
31,015,825Effects of hormones and of ethanol on the fructose 6-P-fructose 1,6-P2 futile cycle during gluconeogenesis in the liver.Arch Biochem Biophys1976https://conductscience.org/library/papers/1015825PubMed
412,821Partial purification and properties of a cyclic 3',5'-AMP-independent protein kinase from rat liver.Biochim Biophys Acta1977https://conductscience.org/library/papers/12821PubMed
511,750The purification of properties of rat liver fructose 1,6-bisphosphatase.Arch Biochem Biophys1976https://conductscience.org/library/papers/11750PubMed
6187,175Purification and characterization of the catalytic subunit of adenosine 3':5'-cyclic monophosphate-dependent protein kinase from bovine liver.Biochem J1976https://conductscience.org/library/papers/187175PubMed
71,008,876Control of pyruvate kinase activity by glucagon in isolated hepatocytes.Biochem Biophys Res Commun1976https://conductscience.org/library/papers/1008876PubMed
84,373,461Rapid reciprocal changes in rat hepatic glycolytic enzyme and fructose diphosphatase activities following insulin and glucagon injection.J Biol Chem1974https://conductscience.org/library/papers/4373461PubMed
94,370,466The fructose 1,6-diphosphatase-phosphofructokinase substrate cycle. A site of regulation of hepatic gluconeogenesis by glucagon.J Biol Chem1974https://conductscience.org/library/papers/4370466PubMed
104,335,482Fructose 1, 6-diphosphatase from liver: isolation of the native form with optimal activity at neutral pH.Arch Biochem Biophys1971https://conductscience.org/library/papers/4335482PubMed
114,326,772Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.Biochemistry1971https://conductscience.org/library/papers/4326772PubMed
124,328,833Reversible inactivation of rabbit liver fructose 1,6-diphosphatase by adenosine triphosphate and adenosine diphosphate.J Biol Chem1971https://conductscience.org/library/papers/4328833PubMed
134,353,268Role of oleate in the regulation of "neutral" rabbit liver fructose 1,6-diphosphatase activity.J Biol Chem1973https://conductscience.org/library/papers/4353268PubMed
144,289,864Reversible inactivation of D-fructose 1,6-diphosphatase by adenosine triphosphate and cyclic 3' ,5'-adenosine monophosphate.Arch Biochem Biophys1966https://conductscience.org/library/papers/4289864PubMed
154,284,291Fructose diphosphatase from rabbit liver. I. Purification and properties.J Biol Chem1965https://conductscience.org/library/papers/4284291PubMed
168,778Dual role of Zn2+ as inhibitor and activator of fructose 1,6-bisphosphatase of rat liver.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/8778PubMed
17183,209Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes.Proc Natl Acad Sci U S A1976https://conductscience.org/library/papers/183209PubMed
18180,008Hepatic pyruvate kinase. Regulation by glucagon, cyclic adenosine 3'-5'-monophosphate, and insulin in the perfused rat liver.J Biol Chem1976https://conductscience.org/library/papers/180008PubMed
19167,014Regulation of glycogen synthetase. Specificity and stoichiometry of phosphorylation of the skeletal muscle enzyme by cyclic 3':5'-AMP-dependent protein kinase.J Biol Chem1975https://conductscience.org/library/papers/167014PubMed
20165,668Mechanisms of control for cAMP-dependent protein kinase from skeletal muscle.Adv Cyclic Nucleotide Res1975https://conductscience.org/library/papers/165668PubMed
21174,740Regulation in vitro of rat liver pyruvate kinase by phosphorylation-dephosphorylation reactions, catalyzed by cyclic-AMP dependent protein kinases and a histone phosphatase.Biochim Biophys Acta1976https://conductscience.org/library/papers/174740PubMed

See all 21 references

Cited by14

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 130 citations.

PMIDTitleJournalYearIn PapersSource
20,116,906Designing inhibitors against fructose 1,6-bisphosphatase: exploring natural products for novel inhibitor scaffolds.Eur J Med Chem2010https://conductscience.org/library/papers/20116906PubMed
19,419,876A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase.Bioorg Med Chem2009https://conductscience.org/library/papers/19419876PubMed
12,562,792QscR, a LysR-type transcriptional regulator and CbbR homolog, is involved in regulation of the serine cycle genes in Methylobacterium extorquens AM1.J Bacteriol2003https://conductscience.org/library/papers/12562792PubMed
8,931,152Evidence for an active T-state pig kidney fructose 1,6-bisphosphatase: interface residue Lys-42 is important for allosteric inhibition and AMP cooperativity.Protein Sci1996https://conductscience.org/library/papers/8931152PubMed
6,285,896A method for determining kinetic parameters at high enzyme concentrations.Biochem J1982https://conductscience.org/library/papers/6285896PubMed
6,272,698Study of the fructose 6-phosphate/fructose 1,6-bi-phosphate cycle in the liver in vivo.Biochem J1980https://conductscience.org/library/papers/6272698PubMed
6,264,456Fructose-bisphosphatase as a substrate of cyclic AMP-dependent protein kinase.Proc Natl Acad Sci U S A1981https://conductscience.org/library/papers/6264456PubMed
6,256,741Mechanism of action of glucagon on hepatocyte phosphofructokinase activity.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6256741PubMed
6,251,334Glucagon and N6,O2'-dibutyryl adenosine 3':5'-monophosphate inhibition of lipogenesis and phosphofructokinase activity of hepatocytes from meal-fed rats.Lipids1980https://conductscience.org/library/papers/6251334PubMed
6,240,979Difference in glucose sensitivity of liver glycolysis and glycogen synthesis. Relationship between lactate production and fructose 2,6-bisphosphate concentration.Biochem J1984https://conductscience.org/library/papers/6240979PubMed
6,089,751Effects of phosphorylation on the kinetic properties of rat liver fructose-1,6-bisphosphatase.Biochem J1984https://conductscience.org/library/papers/6089751PubMed
2,847,161cDNA sequence of rat liver fructose-1,6-bisphosphatase and evidence for down-regulation of its mRNA by insulin.Proc Natl Acad Sci U S A1988https://conductscience.org/library/papers/2847161PubMed
2,822,019Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues.Biochem J1987https://conductscience.org/library/papers/2822019PubMed
508,304The maximum activities of enzymes that are involved in substrate cycles in liver and muscle of obese mice.Biochem J1979https://conductscience.org/library/papers/508304PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

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  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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