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Paper508304

The maximum activities of enzymes that are involved in substrate cycles in liver and muscle of obese mice.

Newsholme EA and 4 others. Biochem J, 1979. Cited by 16 papers, by iCite.

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ConductScience Library. The maximum activities of enzymes that are involved in substrate cycles in liver and muscle of obese mice. Papers, record 508304. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/508304

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The maximum activities of enzymes that are involved in substrate cycles in liver and muscle of obese mice.
PubMed
Journal
Biochem J
PubMed
Year
1979
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
16
iCite
Relative citation ratio, by iCite
0.53
iCite
Revised in PubMed
2019-05-01
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Newsholme EAE A
2Brand KK
3Lang JJ
4Stanley JCJ C
5Williams TT

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
LiverMajor topic
MusclesMajor topic
ObesityMajor topic
Animals
Female
Mice
Mice, Inbred C57BL
Mice, Obese
Oxidoreductases

Source PubMed

References30

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
1215,127Maximum activities and effects of fructose bisphosphate on pyruvate kinase from muscles of vertebrates and invertebrates in relation to the control of glycolysis.Biochem J1978https://conductscience.org/library/papers/215127PubMed
2184,791Substrate cycles in metabolic regulation and in heat generation.Biochem Soc Symp1976https://conductscience.org/library/papers/184791PubMed
311,947,366A switch mechanism in the regulation of glycolysis and gluconeogenesis in rat liver.FEBS Lett1970https://conductscience.org/library/papers/11947366PubMed
44,356,656Isotopic evidence for futile cycles in liver cells.Biochem Biophys Res Commun1973https://conductscience.org/library/papers/4356656PubMed
5148,427Enzymatic studies of liver cells obtained by fine needle biopsy from mice with the obese-hyperglycemic syndrome (genesymbol ob).Horm Metab Res1978https://conductscience.org/library/papers/148427PubMed
64,345,717Adipose and liver tissue enzyme profiles in obese hyperglycemic mice.Proc Soc Exp Biol Med1973https://conductscience.org/library/papers/4345717PubMed
7146,880An enzymatic defect in the obese (ob/ob) mouse: loss of thyroid-induced sodium- and potassium-dependent adenosinetriphosphatase.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/146880PubMed
86,059,953Glucose-6-phosphate dehydrogenase from rat liver. I. Crystallization and properties.J Biochem1967https://conductscience.org/library/papers/6059953PubMed
94,355,239Letter: Accelerated substrate cycling of fructose-6-phosphate in the muscle of malignant hyperthermic pigs.Nature1973https://conductscience.org/library/papers/4355239PubMed
104,342,385The activities of phosphorylase, hexokinase, phosphofructokinase, lactate dehydrogenase and the glycerol 3-phosphate dehydrogenases in muscles from vertebrates and invertebrates.Biochem J1972https://conductscience.org/library/papers/4342385PubMed
114,354,325The activities of pyruvate carboxylase, phosphoenolpyruvate carboxylase and fructose diphosphatase in muscles from vertebrates and invertebrates.Biochem J1972https://conductscience.org/library/papers/4354325PubMed
125,558,136An estimation of pyruvate recycling during gluconeogenesis in the perfused rat liver.Arch Biochem Biophys1971https://conductscience.org/library/papers/5558136PubMed
13200,922In vivo and in vitro phosphorylation of rat liver fructose-1,6-bisphosphatase.Proc Natl Acad Sci U S A1977https://conductscience.org/library/papers/200922PubMed
14155,456Substrate cycles: their metabolic, energetic and thermic consequences in man.Biochem Soc Symp1978https://conductscience.org/library/papers/155456PubMed
154,294,451Hepatic glycolytic and gluconeogenic enzymes of the obese-hyperglycemic mouse.Biochim Biophys Acta1967https://conductscience.org/library/papers/4294451PubMed
1613,783
The maximum activities of hexokinase, phosphorylase, phosphofructokinase, glycerol phosphate dehydrogenases, lactate dehydrogenase, octopine dehydrogenase, phosphoenolpyruvate carboxykinase, nucleoside diphosphatekinase, glutamate-oxaloacetate transaminase and arginine kinase in relation to carbohydrate utilization in muscles from marine invertebrates.
Biochem J1976https://conductscience.org/library/papers/13783PubMed
17191,317The role of the fructose 6-phosphate/fructose 1,6-diphosphate cycle in metabolic regulation and heat generation.Biochem Soc Trans1976https://conductscience.org/library/papers/191317PubMed
18849,291The release of alanine by rat diaphragm muscle in vitro.Biochem J1977https://conductscience.org/library/papers/849291PubMed
195,278,387Insulin resistance in genetically obese, hyperglycemic mice.Endocrinology1971https://conductscience.org/library/papers/5278387PubMed
20217,368The role of phosphoenolpyruvate carboxykinase in amino acid metabolism in muscle.Biochem J1978https://conductscience.org/library/papers/217368PubMed

See all 30 references

Cited by5

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 16 citations.

PMIDTitleJournalYearIn PapersSource
38,960,128Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism.Mol Metab2024https://conductscience.org/library/papers/38960128PubMed
32,230,955Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats.Nutrients2020https://conductscience.org/library/papers/32230955PubMed
6,517,870Activities of glucokinase and hexokinase in mammalian and avian livers.Biochem J1984https://conductscience.org/library/papers/6517870PubMed
6,289,811Limitations of commonly used spectrophotometric assay methods for phosphoenolypyruvate carboxykinase activity in crude extracts of muscle.Biochem J1982https://conductscience.org/library/papers/6289811PubMed
3,800,971Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages.Biochem J1986https://conductscience.org/library/papers/3800971PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Grants
  • Trials
  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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