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Paper · 88498

In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T-dependent responsive B cells by antigen.

Teale JM and 2 others. J Exp Med, 1979. Cited by 40 papers, by iCite.

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ConductScience Library. In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T-dependent responsive B cells by antigen. Papers, record 88498. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/88498

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
In vitro model for natural tolerance to self-antigens. Inhibition of the development of surface-immunoglobulin-negative lymphocytes into T-dependent responsive B cells by antigen.
PubMed
Journal
J Exp Med
PubMed
Year
1979
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
40
iCite
Relative citation ratio, by iCite
0.72
iCite
Revised in PubMed
2019-05-08
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Teale JMJ M
2Layton JEJ E
3Nossal GJG J

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AntigensMajor topic
AutoantigensMajor topic
Immune ToleranceMajor topic
Animals
Antibody Formation
B-Lymphocytes
Dinitrophenols
Female
Hemocyanins
Lymphocytes
Mice
Receptors, Antigen, B-Cell
T-Lymphocytes
gamma-Globulins

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References27

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,078,838Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T lymphocytes.J Exp Med1975https://conductscience.org/library/papers/1078838PubMed
21,084,409Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.J Exp Med1976https://conductscience.org/library/papers/1084409PubMed
31,086,883Allogeneic carrier-specific enhancement of hapten-specific secondary B-cell responses.J Exp Med1976https://conductscience.org/library/papers/1086883PubMed
41,087,319Ontogeny of the antibody-forming cell line in mice. II. Maturation of B cells during fetal development.J Immunol1976https://conductscience.org/library/papers/1087319PubMed
6212,480B lymphocyte precursors. I. Induction of lipopolysaccharide responsiveness and surface immunoglobulin expression in vitro.J Immunol1978https://conductscience.org/library/papers/212480PubMed
7301,175Ontogeny of B-lymphocyte function. III. In vivo and in vitro studies on the ease of tolerance induction in B lymphocytes from fetal, neonatal, and adult mice.J Exp Med1977https://conductscience.org/library/papers/301175PubMed
8305,047Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.Proc Natl Acad Sci U S A1978https://conductscience.org/library/papers/305047PubMed
94,114,497The mechanism of antigenic stimulation of primary and secondary clonal precursor cells.J Exp Med1972https://conductscience.org/library/papers/4114497PubMed
104,119,591Fate of antigen-binding cells in unresponsive and immune mice.J Exp Med1973https://conductscience.org/library/papers/4119591PubMed
11412,679Immunofluorescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans.Eur J Immunol1977https://conductscience.org/library/papers/412679PubMed

1 to 10 of 27

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Cited by7

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 40 citations.

PMIDTitleJournalYearIn PapersSource
7,051,837Autoimmune diseases: immunopathology and etiopathogenesis.Am J Pathol1982https://conductscience.org/library/papers/7051837PubMed
6,966,401Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen.Proc Natl Acad Sci U S A1980https://conductscience.org/library/papers/6966401PubMed
6,965,399Ontogenic development of B-lymphocyte function and tolerance susceptibility in vivo and in an in vitro organ culture system.J Exp Med1980https://conductscience.org/library/papers/6965399PubMed
6,434,687Long-term cultures of murine fetal liver retain very early B lymphoid phenotype.J Exp Med1984https://conductscience.org/library/papers/6434687PubMed
3,500,260Relationship between expression of IgA by Peyer's patch cells and functional IgA memory cells.J Exp Med1987https://conductscience.org/library/papers/3500260PubMed
3,261,774Comparison of the fetal and adult functional B cell repertoires by analysis of VH gene family expression.J Exp Med1988https://conductscience.org/library/papers/3261774PubMed
1,971,834Molecular analysis of neonatal IgA expression: implications for class switching, allelic polymorphism and somatic mutation.Immunol Res1990https://conductscience.org/library/papers/1971834PubMed

Genes0

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

None in this release.

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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