Paper890212

Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins.

Whittle BJ. Br J Pharmacol, 1977. Cited by 264 papers, by iCite.

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ConductScience Library. Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins. Papers, record 890212. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/890212

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins.; PubMed
Journal: Br J Pharmacol; PubMed
Year: 1977; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/890212/; PubMed
DOI: https://doi.org/10.1111/j.1476-5381.1977.tb07522.x; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC1667280/; PubMed
The journal: https://conductscience.org/library/journal-index/7502536; PubMed
Citations, by iCite: 264; iCite
Relative citation ratio, by iCite: 11.2; iCite
Revised in PubMed: 2019-05-09; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Whittle BJ	B J

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Gastric Mucosa	Major topic
Indomethacin	Major topic
Prostaglandins E	Major topic
Taurocholic Acid	Major topic
Acids
Animals
Diffusion
Drug Interactions
In Vitro Techniques
Membrane Potentials
Prostaglandins, Synthetic
Rats
Regional Blood Flow

Source PubMed

Show 7 more topicsShow fewer topics

References19

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	14,288,545	PATHOGENESIS OF GASTRIC ULCERATION.	Lancet	1965	https://conductscience.org/library/papers/14288545	PubMed
2	5,711,899	Destruction of the gastric mucosal barrier by detergents and urea.	Gastroenterology	1968	https://conductscience.org/library/papers/5711899	PubMed
3	5,009,716	The effect of several ulcerogenic drugs on the canine gastric mucosal barrier.	J Lab Clin Med	1972	https://conductscience.org/library/papers/5009716	PubMed
4	5,284,360	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	Nat New Biol	1971	https://conductscience.org/library/papers/5284360	PubMed
5	4,149,696	The effects E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat.	Br J Pharmacol	1973	https://conductscience.org/library/papers/4149696	PubMed
6	238,294	Effect of aspirin, bile salt, and ethanol on canine gastric mucosal blood flow.	Surgery	1975	https://conductscience.org/library/papers/238294	PubMed
7	235,482	Acute gastric mucosal damage induced by bile salts, acid, and ischemia.	Gastroenterology	1975	https://conductscience.org/library/papers/235482	PubMed
8	167,892	Investigation of the vasodilator and antisecretory role of prostaglandins in the rat gastric mucosa by use of non-steroidal anti-inflammatory drugs.	Br J Pharmacol	1975	https://conductscience.org/library/papers/167892	PubMed
9	4,795,759	Prevention of aspirin-induced gastric ulceration by bile duct or pylorus ligation in the rat.	Gastroenterology	1973	https://conductscience.org/library/papers/4795759	PubMed
10	4,777,713	Gastric mucosal blood flow during pentagastrin- and histamine-stimulated acid secretion in the rat.	Br J Pharmacol	1973	https://conductscience.org/library/papers/4777713	PubMed
11	4,686,333	Effect of bile salts and aspirin on the gastric mucosal blood flow.	Gastroenterology	1973	https://conductscience.org/library/papers/4686333	PubMed
12	5,039,393	Absorption of bile salts from the gastric mucosa during hemorrhagic shock.	Proc Soc Exp Biol Med	1972	https://conductscience.org/library/papers/5039393	PubMed
13	1,083,823	Effect of prostaglandin 15(R) 15 methyl-E2 methyl ester on aspirin and taurocholic acid-induced gastric mucosal haemorrhage in rats.	Gut	1976	https://conductscience.org/library/papers/1083823	PubMed
14	1,078,804	Role of bile acids in the pathogenesis of aspirin-induced gastric mucosal hemorrhage in rats.	Gastroenterology	1975	https://conductscience.org/library/papers/1078804	PubMed
15	1,260,181	Proceedings: Prostaglandins and changes in the gastric mucosal barrier and blood flow during indomethacin- and bile salt-induced mucosal damage.	Br J Pharmacol	1976	https://conductscience.org/library/papers/1260181	PubMed
16	1,201,386	Proceedings: Gastric acidity and the mechanisms by which prostaglandins prevent indomethacin-induced gastric erosions.	Br J Pharmacol	1975	https://conductscience.org/library/papers/1201386	PubMed
17	1,164,591	Potency and selectivity of methyl analogues of prostaglandin E2 on rat gastrointestinal function.	Br J Pharmacol	1975	https://conductscience.org/library/papers/1164591	PubMed
18	1,115,871	Decreased incidence of indomethacin-induced gastric ulceration in rats by bile duct diversion.	Br J Surg	1975	https://conductscience.org/library/papers/1115871	PubMed
19	11,107	Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins.	Eur J Pharmacol	1976	https://conductscience.org/library/papers/11107	PubMed

Show 13 more referencesShow fewer references

Cited by57

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 264 citations.

PMID	Title	Journal	Year	In Papers	Source
34,938,796	Clinical Features and Risk Factors for Gastrointestinal Complications in Dogs Treated Surgically for Thoracolumbar Intervertebral Disc Extrusion.	Front Vet Sci	2021	https://conductscience.org/library/papers/34938796	PubMed
30,785,904	Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.	PLoS One	2019	https://conductscience.org/library/papers/30785904	PubMed
28,766,164	Effect of Aspirin and ibuprofen either alone or in combination on gastric mucosa and bleeding time and on serum prostaglandin E2 and thromboxane A2 levels in the anaesthetized rats in vivo.	Mol Cell Biochem	2018	https://conductscience.org/library/papers/28766164	PubMed
25,382,984	Observational study of upper gastrointestinal tract bleeding events in patients taking duloxetine and nonsteroidal anti-inflammatory drugs: a case-control analysis.	Drug Healthc Patient Saf	2014	https://conductscience.org/library/papers/25382984	PubMed
24,695,819	Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways.	Adv Pharmacol Sci	2014	https://conductscience.org/library/papers/24695819	PubMed
24,653,572	Cytoprotective and antioxidant effects of the methanol extract of Eremomastax speciosa in rats.	Afr J Tradit Complement Altern Med	2014	https://conductscience.org/library/papers/24653572	PubMed
23,745,031	Gastric antisecretory and antiulcer activity of bovine hemoglobin.	World J Gastroenterol	2013	https://conductscience.org/library/papers/23745031	PubMed
19,557,311	Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings.	Inflammopharmacology	2009	https://conductscience.org/library/papers/19557311	PubMed
18,671,842	A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages.	J Inflamm (Lond)	2008	https://conductscience.org/library/papers/18671842	PubMed
17,131,481	Protective effects of amphetamine on gastric ulcerations induced by indomethacin in rats.	World J Gastroenterol	2006	https://conductscience.org/library/papers/17131481	PubMed
16,702,997	Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets.	Br J Pharmacol	2006	https://conductscience.org/library/papers/16702997	PubMed
11,960,558	2, 4-diamino-6- hydroxy pyrimidine inhibits NSAIDs induced nitrosyl-complex EPR signals and ulcer in rat jejunum.	BMC Gastroenterol	2002	https://conductscience.org/library/papers/11960558	PubMed
11,852,880	NSAID gastric ulceration: predictive value of gastric pH, mucosal density of polymorphonuclear leukocytes, or levels of IL-8 or nitrite.	Dig Dis Sci	2002	https://conductscience.org/library/papers/11852880	PubMed
11,270,787	Effect of diet on changes in small intestinal blood flow following intracolonic administration of indomethacin to rats.	Dig Dis Sci	2001	https://conductscience.org/library/papers/11270787	PubMed
9,824,604	Enantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat.	Gut	1998	https://conductscience.org/library/papers/9824604	PubMed
9,575,302	Mediation by 5_hydroxytryptamine of the femoral vasoconstriction induced by acid challenge of the rat gastric mucosa.	J Physiol	1998	https://conductscience.org/library/papers/9575302	PubMed
9,378,390	Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine.	Gut	1997	https://conductscience.org/library/papers/9378390	PubMed
9,331,150	Gastric mucosal blood flow regulation in response to different stimuli.	Dig Dis Sci	1997	https://conductscience.org/library/papers/9331150	PubMed
8,982,497	Tachykinin inhibition of acid-induced gastric hyperaemia in the rat.	Br J Pharmacol	1996	https://conductscience.org/library/papers/8982497	PubMed
8,391,973	Mechanism by which histamine increases gastric mucosal blood flow in the rat. Role of luminal H+.	Dig Dis Sci	1993	https://conductscience.org/library/papers/8391973	PubMed

Show 14 more cited byShow fewer cited bySee all 57 cited by

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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NIH RePORTER's grant and paper linksPublic domain
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PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
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