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Paper1164591

Potency and selectivity of methyl analogues of prostaglandin E2 on rat gastrointestinal function.

Main IH and 1 other. Br J Pharmacol, 1975. Cited by 41 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Potency and selectivity of methyl analogues of prostaglandin E2 on rat gastrointestinal function. Papers, record 1164591. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/1164591

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Potency and selectivity of methyl analogues of prostaglandin E2 on rat gastrointestinal function.
PubMed
Journal
Br J Pharmacol
PubMed
Year
1975
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
41
iCite
Relative citation ratio, by iCite
1.79
iCite
Revised in PubMed
2019-05-09
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Main IHI H
2Whittle BJB J

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Digestive System Physiological PhenomenaMajor topic
Prostaglandins EMajor topic
Anesthesia
Animals
Blood Pressure
Diarrhea
Gastric Juice
Gastric Mucosa
Gastrointestinal Motility
In Vitro Techniques
Methylation
Rats
Regional Blood Flow
Structure-Activity Relationship
Time Factors

Source PubMed

References15

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
14,153,444Proceedings: Failure of burimamide and (15S)-15-methyl prostaglandin E2 to prevent histamine-induced gastric mucosal hyperaemia in the rat.J Physiol1974https://conductscience.org/library/papers/4153444PubMed
25,698,627Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat.Gastroenterology1968https://conductscience.org/library/papers/5698627PubMed
34,149,696The effects E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat.Br J Pharmacol1973https://conductscience.org/library/papers/4149696PubMed
44,448,083Midtrimester abortion with intramuscular injection of 15-methyl-prostaglandin E2.Contraception1974https://conductscience.org/library/papers/4448083PubMed
54,850,371Abortifacient action of orally administered 16,16 dimethyl prostaglandin E2 and its methyl ester.Prostaglandins1974https://conductscience.org/library/papers/4850371PubMed
64,850,777Biological activity of the methyl esters of prostaglandin E2 and its (15S)-15-methyl analogue.Eur J Pharmacol1974https://conductscience.org/library/papers/4850777PubMed
74,823,988Marked inhibition of gastric secretion by two prostaglandin analogs given orally to man.Life Sci1974https://conductscience.org/library/papers/4823988PubMed
84,777,713Gastric mucosal blood flow during pentagastrin- and histamine-stimulated acid secretion in the rat.Br J Pharmacol1973https://conductscience.org/library/papers/4777713PubMed
94,732,565Action of caerulein and related substances on the pyloric sphincter of the anaesthetized rat.Eur J Pharmacol1973https://conductscience.org/library/papers/4732565PubMed
104,723,314The biological activity of the (15S)-15-methyl analogs of prostaglandins. E2 and F2a.J Pharmacol Exp Ther1973https://conductscience.org/library/papers/4723314PubMed
114,706,806Effect of orally administered prostaglandin E 2 and its 15-methyl analogues on gastric secretion.Br Med J1973https://conductscience.org/library/papers/4706806PubMed
124,938,721A new method for measuring gastric acid secretion in unanesthetized rats.Gastroenterology1971https://conductscience.org/library/papers/4938721PubMed
135,115,089The effect of prostaglandin E 1 on the pentagastrin-stimulated gastric secretion in man.Digestion1971https://conductscience.org/library/papers/5115089PubMed
145,717,966Effect of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man.Gut1968https://conductscience.org/library/papers/5717966PubMed
154,137,140Prostaglandin E2 and the stimulation of rat gastric acid secretion by dibutyryl cyclic 3',5'-AMP.Eur J Pharmacol1974https://conductscience.org/library/papers/4137140PubMed

Cited by10

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 41 citations.

PMIDTitleJournalYearIn PapersSource
30,096,040Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation.FASEB J2019https://conductscience.org/library/papers/30096040PubMed
6,337,659Inhibition of gastric acid secretion by intracerebroventricularly administered prostaglandin e2 in anaesthetized rats.Br J Pharmacol1983https://conductscience.org/library/papers/6337659PubMed
3,932,048Misoprostol, a synthetic PGE1 analog, in the treatment of duodenal ulcers. A multicenter double-blind study.Dig Dis Sci1985https://conductscience.org/library/papers/3932048PubMed
3,470,106Failure of prostaglandin E2 and its 16,16-dimethyl analogue to prevent the gastric mucosal damage induced by Paf.Br J Pharmacol1987https://conductscience.org/library/papers/3470106PubMed
1,201,386Proceedings: Gastric acidity and the mechanisms by which prostaglandins prevent indomethacin-induced gastric erosions.Br J Pharmacol1975https://conductscience.org/library/papers/1201386PubMed
950,600A study of the vascular and acid-secretory responses of the rat gastric mucosa to histamine.J Physiol1976https://conductscience.org/library/papers/950600PubMed
890,212Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins.Br J Pharmacol1977https://conductscience.org/library/papers/890212PubMed
827,937Gastric antisecretory effects of E prostaglandins in Rhesus monkeys.Am J Dig Dis1976https://conductscience.org/library/papers/827937PubMed
824,000Stimulation of prostaglandin biosynthesis by drugs: effects in vitro of some drugs affecting gut function.Br J Pharmacol1976https://conductscience.org/library/papers/824000PubMed
623,940Uptake and inactivation of prostaglandin E2 methyl analogues in the rat pulmonary circulation.Br J Pharmacol1978https://conductscience.org/library/papers/623940PubMed

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

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  • Comments and corrections
  • Genes
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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