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Paper · 8970949

Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection.

Karupiah G and 4 others. J Virol, 1996. Cited by 140 papers, by iCite.

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ConductScience Library. Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection. Papers, record 8970949. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/8970949

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection.
PubMed
Journal
J Virol
PubMed
Year
1996
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
140
iCite
Relative citation ratio, by iCite
2.89
iCite
Revised in PubMed
2020-07-24
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Karupiah GG
2Buller RMR M
3Van Rooijen NN
4Duarte CJC J
5Chen JJ

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CD4-Positive T-LymphocytesMajor topic
CD8-Positive T-LymphocytesMajor topic
Ectromelia virusMajor topic
Ectromelia, InfectiousMajor topic
MacrophagesMajor topic
Animals
Cell Line
Chlorocebus aethiops
Cytotoxicity, Immunologic
Female
Flow Cytometry
Mice
Mice, Inbred C57BL
Spleen
Virus Replication
beta 2-Microglobulin

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References53

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
12,295,796Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2.J Immunol1990https://conductscience.org/library/papers/2295796PubMed
214,422,711The response of mice to large intravenous injections of ectromelia virus. I. The fate of injected virus.Br J Exp Pathol1959https://conductscience.org/library/papers/14422711PubMed
31,546,448Restricted replication of ectromelia virus in cell culture correlates with mutations in virus-encoded host range gene.Virology1992https://conductscience.org/library/papers/1546448PubMed
41,631,092Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses.Proc Natl Acad Sci U S A1992https://conductscience.org/library/papers/1631092PubMed
58,083,541Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications.J Immunol Methods1994https://conductscience.org/library/papers/8083541PubMed
6212,503Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.J Exp Med1978https://conductscience.org/library/papers/212503PubMed
72,822,845A role for early cytotoxic T cells in resistance to ectromelia virus infection in mice.J Gen Virol1987https://conductscience.org/library/papers/2822845PubMed
87,966,595CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.J Virol1994https://conductscience.org/library/papers/7966595PubMed
98,539,616Immunology taught by viruses.Science1996https://conductscience.org/library/papers/8539616PubMed
107,690,156Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase.Science1993https://conductscience.org/library/papers/7690156PubMed

1 to 10 of 53

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Cited by86

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 140 citations.

PMIDTitleJournalYearIn PapersSource
42,432,776Virtual memory CD8⁺ T cells in aging: heterogeneity, bystander protection, inflammatory potential, and inhibitory regulation.Immun Ageing2026https://conductscience.org/library/papers/42432776PubMed
41,660,658Persistent Immunity From Historic Smallpox Vaccination and Its Limited Cross-Neutralization of Monkeypox Virus: A Population-based Serological Study in Taiwan.Open Forum Infect Dis2026https://conductscience.org/library/papers/41660658PubMed
39,813,296MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as a model of βHPV in typical epidermodysplasia verruciformis.PLoS Pathog2025https://conductscience.org/library/papers/39813296PubMed
39,203,972
A Pseudovirus Nanoparticle Displaying the Vaccinia Virus L1 Protein Elicited High Neutralizing Antibody Titers and Provided Complete Protection to Mice against Mortality Caused by a Vaccinia Virus Challenge.
Vaccines (Basel)2024https://conductscience.org/library/papers/39203972PubMed
36,553,622Genetic Variants and Protective Immunity against SARS-CoV-2.Genes (Basel)2022https://conductscience.org/library/papers/36553622PubMed
35,679,859Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses.Cancer Cell2022https://conductscience.org/library/papers/35679859PubMed
34,107,993Zoonotic vaccinia virus strains belonging to different genetic clades exhibit immunomodulation abilities that are proportional to their virulence.Virol J2021https://conductscience.org/library/papers/34107993PubMed
34,015,056Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells.PLoS Pathog2021https://conductscience.org/library/papers/34015056PubMed
33,113,212COVID-19, varying genetic resistance to viral disease and immune tolerance checkpoints.Immunol Cell Biol2021https://conductscience.org/library/papers/33113212PubMed
33,046,647Poxvirus-encoded TNF receptor homolog dampens inflammation and protects from uncontrolled lung pathology during respiratory infection.Proc Natl Acad Sci U S A2020https://conductscience.org/library/papers/33046647PubMed

1 to 10 of 86

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Genes1

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn Genes
B2M567PubTator's text mininghttps://conductscience.org/library/genes/567

Source NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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