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Paper · 212503

Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.

Zinkernagel RM and 9 others. J Exp Med, 1978. Cited by 190 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness. Papers, record 212503. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/212503

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.
PubMed
Journal
J Exp Med
PubMed
Year
1978
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
190
iCite
Relative citation ratio, by iCite
3.79
iCite
Revised in PubMed
2019-05-08
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Zinkernagel RMR M
2Althage AA
3Cooper SS
4Kreeb GG
5Klein PAP A
6Sefton BB
7Flaherty LL
8Stimpfling JJ
9Shreffler DD
10Klein JJ

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cytotoxicity, ImmunologicMajor topic
Genes, MHC Class IIMajor topic
H-2 AntigensMajor topic
Major Histocompatibility ComplexMajor topic
T-LymphocytesMajor topic
Virus DiseasesMajor topic
Alleles
Animals
Genes, Dominant
Immunity, Cellular
Lymphocytic choriomeningitis virus
Mice
Parainfluenza Virus 1, Human
Vaccinia virus

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References26

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,073,428Determinant selection is a macrophage dependent immune response gene function.Nature1977https://conductscience.org/library/papers/16073428PubMed
2194,830Specific immune lysis of paramyxovirus-infected cells by H-2-compatible thymus-derived lymphocytes.Immunology1976https://conductscience.org/library/papers/194830PubMed
370,400Responsiveness to HY antigen Ir gene complementation and target cell specificity.Immunol Rev1977https://conductscience.org/library/papers/70400PubMed
467,564Selective incorporation of H-2 antigenic determinants into Friend virus particles.Nature1977https://conductscience.org/library/papers/67564PubMed
569,515Major transplantation antigens, viruses, and specificity of surveillance T cells.Contemp Top Immunobiol1977https://conductscience.org/library/papers/69515PubMed
6416,165Cytotoxic T-cell responses to H-Y: mapping of the Ir genes.J Exp Med1978https://conductscience.org/library/papers/416165PubMed
7305,460The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.J Exp Med1978https://conductscience.org/library/papers/305460PubMed
8305,459On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?J Exp Med1978https://conductscience.org/library/papers/305459PubMed
9306,412Cytotoxic T cells recognize male antigen and H-2 as distinct entities.J Exp Med1978https://conductscience.org/library/papers/306412PubMed
101,087,329
Multiple H-2 linked immune response gene control of H-2 D-associated T-cell-mediated lympholysis to trinitrophenyl-modified autologous cells: Ir-like genes mapping to the left of I-A and within the I region.
J Exp Med1976https://conductscience.org/library/papers/1087329PubMed

1 to 10 of 26

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Cited by57

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 190 citations.

PMIDTitleJournalYearIn PapersSource
42,154,434Golden age of Czechoslovak immunology and what followed - a personal view.Folia Microbiol (Praha)2026https://conductscience.org/library/papers/42154434PubMed
23,840,854MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies.PLoS One2013https://conductscience.org/library/papers/23840854PubMed
23,202,497How much of virus-specific CD8 T cell reactivity is detected with a peptide pool when compared to individual peptides?Viruses2012https://conductscience.org/library/papers/23202497PubMed
22,457,931Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk.Immunogenetics1980https://conductscience.org/library/papers/22457931PubMed
21,536,802Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function.J Immunol2011https://conductscience.org/library/papers/21536802PubMed
21,302,107Murine cytotoxic T-cell response to alphavirus is associated mainly withH- 2D ( k ).Immunogenetics1978https://conductscience.org/library/papers/21302107PubMed
19,949,110Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.J Immunol2010https://conductscience.org/library/papers/19949110PubMed
8,970,949Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection.J Virol1996https://conductscience.org/library/papers/8970949PubMed
7,525,843Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.J Exp Med1994https://conductscience.org/library/papers/7525843PubMed
7,333,657Variation of expression of histocompatibility antigens on tumor cells: absence of H-2Kk-gene products from a gross-virus-induced leukemia in BALB.K.Immunogenetics1981https://conductscience.org/library/papers/7333657PubMed

1 to 10 of 57

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Genes2

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
HLA-A3,105PubTator's text mininghttps://conductscience.org/library/genes/3105NCBI Gene
INSR3,643PubTator's text mininghttps://conductscience.org/library/genes/3643NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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