Paper92518
Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation.
Kubagawa H and 5 others. J Exp Med, 1979. Cited by 258 papers, by iCite.
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ConductScience Library. Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation. Papers, record 92518. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/92518
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation.
- PubMed
Topics12
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Antibodies, Neoplasm | Major topic |
| B-Lymphocytes | Major topic |
| Immunoglobulin Idiotypes | Major topic |
| Multiple Myeloma | Major topic |
| Antibody Specificity | |
| Antigens, Neoplasm | |
| Cell Differentiation | |
| Epitopes | |
| Humans | |
| Immunoglobulin A | |
| Myeloma Proteins | |
| Plasma Cells |
Source PubMed
References51
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 102,726 | Pre-B and B cells in rabbits. Ontogeny and allelic exclusion of kappa light chain genes. | J Exp Med | 1978 | https://conductscience.org/library/papers/102726 | PubMed |
| 2 | 1,059,147 | Normal genetically mosaic mice produced from malignant teratocarcinoma cells. | Proc Natl Acad Sci U S A | 1975 | https://conductscience.org/library/papers/1059147 | PubMed |
| 3 | 1,096,701 | The monoclonal nature of lymphocytes in multiple myeloma. Effects of therapy. | Ann Intern Med | 1975 | https://conductscience.org/library/papers/1096701 | PubMed |
| 4 | 1,097,525 | B lymphocyte differentiation induced by lipopolysaccharide. I. Generation of cells synthesizing four major immunoglobulin classes. | J Immunol | 1975 | https://conductscience.org/library/papers/1097525 | PubMed |
| 5 | 1,143,315 | Mutation selection and the natural history of cancer. | Nature | 1975 | https://conductscience.org/library/papers/1143315 | PubMed |
| 6 | 11,993,330 | Induction of T and B cell immunity by anti-idiotypic antibody. | Eur J Immunol | 1975 | https://conductscience.org/library/papers/11993330 | PubMed |
| 7 | 1,254,974 | The chromic chloride method of coupling antigens to erythrocytes: definition of some important parameters. | J Immunol Methods | 1976 | https://conductscience.org/library/papers/1254974 | PubMed |
| 8 | 13,814,555 | Studies of parotid-tumor agent in cultures of leukemic tissues of mice. | J Natl Cancer Inst | 1959 | https://conductscience.org/library/papers/13814555 | PubMed |
| 9 | 14,427,334 | Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds. | Arch Biochem Biophys | 1960 | https://conductscience.org/library/papers/14427334 | PubMed |
| 10 | 14,474,037 | Etiology and pathogenesis of mouse leukemia. | Adv Cancer Res | 1961 | https://conductscience.org/library/papers/14474037 | PubMed |
| 11 | 267,431 | Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. | Am J Med | 1977 | https://conductscience.org/library/papers/267431 | PubMed |
| 12 | 275,854 | Somatic cell origin of teratocarcinomas. | Proc Natl Acad Sci U S A | 1978 | https://conductscience.org/library/papers/275854 | PubMed |
| 13 | 305,541 | Pre-B-cell leukemia. A new phenotype of childhood lymphoblastic leukemia. | N Engl J Med | 1978 | https://conductscience.org/library/papers/305541 | PubMed |
| 14 | 308,953 | Chronic myelocytic leukemia. Origin of some lymphocytes from leukemic stem cells. | J Clin Invest | 1978 | https://conductscience.org/library/papers/308953 | PubMed |
| 15 | 336,835 | Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice. | J Exp Med | 1977 | https://conductscience.org/library/papers/336835 | PubMed |
| 16 | 351,064 | Sequential expression of immunoglobulin on developing mouse B lymphocytes: a systematic survey that suggests a model for the generation of immunoglobulin isotype diversity. | J Immunol | 1978 | https://conductscience.org/library/papers/351064 | PubMed |
| 17 | 376,734 | Shared idiotypes of human peripheral blood B and T lymphocytes. | J Immunol | 1979 | https://conductscience.org/library/papers/376734 | PubMed |
| 18 | 4,115,135 | Idiotypic determinants of immunoglobulin M detected on the surface of human lymphocytes by cytotoxicity assays. | J Exp Med | 1972 | https://conductscience.org/library/papers/4115135 | PubMed |
| 19 | 4,119,588 | Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. | J Exp Med | 1973 | https://conductscience.org/library/papers/4119588 | PubMed |
| 20 | 4,123,388 | Multiple myeloma and benign monoclonal gammopathy: differentiation by immunofluorescence of lymphocytes. | Ann Intern Med | 1973 | https://conductscience.org/library/papers/4123388 | PubMed |
Cited by45
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 258 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 41,674,713 | Cell lineage tracing: Methods, applications, and challenges. | Quant Biol | 2025 | https://conductscience.org/library/papers/41674713 | PubMed |
| 36,844,937 | The utility of chest ultrasound-guided fine-needle biopsy in the diagnosis of plasmacytoma. | Afr J Thorac Crit Care Med | 2022 | https://conductscience.org/library/papers/36844937 | PubMed |
| 31,231,360 | Cell of Origin and Genetic Alterations in the Pathogenesis of Multiple Myeloma. | Front Immunol | 2019 | https://conductscience.org/library/papers/31231360 | PubMed |
| 30,697,210 | Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires. | Front Immunol | 2018 | https://conductscience.org/library/papers/30697210 | PubMed |
| 23,872,308 | Circulating clonotypic B cells in multiple myeloma and monoclonal gammopathy of undetermined significance. | Haematologica | 2014 | https://conductscience.org/library/papers/23872308 | PubMed |
| 23,536,725 | Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model. | Mol Cancer Ther | 2013 | https://conductscience.org/library/papers/23536725 | PubMed |
| 23,176,722 | Can we change the disease biology of multiple myeloma? | Leuk Res | 2012 | https://conductscience.org/library/papers/23176722 | PubMed |
| 20,727,035 | New insights into the enigma of immunoglobulin D. | Immunol Rev | 2010 | https://conductscience.org/library/papers/20727035 | PubMed |
| 18,539,970 | Multiple myeloma cancer stem cells. | J Clin Oncol | 2008 | https://conductscience.org/library/papers/18539970 | PubMed |
| 10,800,062 | Acute lymphoblastic leukaemia-type intensive chemotherapy to eliminate minimal residual disease after high-dose melphalan and autologous transplantation in multiple myeloma - a phase I/II feasibility and tolerance study of 17 patients. | Bone Marrow Transplant | 2000 | https://conductscience.org/library/papers/10800062 | PubMed |
| 9,547,329 | The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cmu-Cdelta switch, and lambda light chain expression. | J Exp Med | 1998 | https://conductscience.org/library/papers/9547329 | PubMed |
| 8,833,916 | Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells. | J Clin Invest | 1996 | https://conductscience.org/library/papers/8833916 | PubMed |
| 8,624,271 | A prognostic index for multiple myeloma. | Br J Cancer | 1996 | https://conductscience.org/library/papers/8624271 | PubMed |
| 8,350,048 | Evidence for a bone marrow B cell transcribing malignant plasma cell VDJ joined to C mu sequence in immunoglobulin (IgG)- and IgA-secreting multiple myelomas. | J Exp Med | 1993 | https://conductscience.org/library/papers/8350048 | PubMed |
| 8,350,044 | The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell. | J Exp Med | 1993 | https://conductscience.org/library/papers/8350044 | PubMed |
| 8,145,046 | Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130. | J Exp Med | 1994 | https://conductscience.org/library/papers/8145046 | PubMed |
| 8,022,463 | Humoral immunoresponse of pigeons to Aspergillus fumigatus antigens. | Mycopathologia | 1993 | https://conductscience.org/library/papers/8022463 | PubMed |
| 7,846,031 | T cells induce terminal differentiation of transformed B cells to mature plasma cell tumors. | Proc Natl Acad Sci U S A | 1995 | https://conductscience.org/library/papers/7846031 | PubMed |
| 7,846,030 | Differentiation and cancer: the conditional autonomy of phenotype. | Proc Natl Acad Sci U S A | 1995 | https://conductscience.org/library/papers/7846030 | PubMed |
| 6,979,553 | Cellular localization of rheumatoid factor idiotypes. | J Clin Invest | 1982 | https://conductscience.org/library/papers/6979553 | PubMed |
Genes1
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes |
|---|---|---|---|
| CD79A | 973 | PubTator's text mining | https://conductscience.org/library/genes/973 |
Source NCBI Gene
Data dates
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- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
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- Data
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- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
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- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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