Paper9709

Liver microsomal uptake of (14C)vinyl chloride and transformation to protein alkylating metabolites in vitro.

Kappus H and 3 others. Toxicol Appl Pharmacol, 1976. Cited by 60 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Liver microsomal uptake of (14C)vinyl chloride and transformation to protein alkylating metabolites in vitro. Papers, record 9709. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/9709

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Liver microsomal uptake of (14C)vinyl chloride and transformation to protein alkylating metabolites in vitro.; PubMed
Journal: Toxicol Appl Pharmacol; PubMed
Year: 1976; PubMed
Publication types: Journal Article; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/9709/; PubMed
DOI: https://doi.org/10.1016/0041-008x(76)90208-8; PubMed
The journal: https://conductscience.org/library/journal-index/0416575; PubMed
Citations, by iCite: 60; iCite
Relative citation ratio, by iCite: 3.45; iCite
Revised in PubMed: 2019-07-27; PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Kappus H	H
2	Bolt HM	H M
3	Buchter A	A
4	Bolt W	W

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Microsomes, Liver	Major topic
Proteins	Major topic
Vinyl Chloride	Major topic
Vinyl Compounds	Major topic
Alkylation
Animals
Biotransformation
Epoxide Hydrolases
Glutathione
In Vitro Techniques
Male
Membranes
NADP
Phenobarbital
Protein Binding
Rats
Time Factors

Source PubMed

Show 11 more topicsShow fewer topics

Cited by16

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 60 citations.

PMID	Title	Journal	Year	In Papers	Source
7,450,889	Monooxygenase activity and ultrastructural changes of liver in the course of chronic exposure of rats to vinyl chloride.	Int Arch Occup Environ Health	1980	https://conductscience.org/library/papers/7450889	PubMed
6,653,541	Relevance of experimental studies to human risk.	Environ Health Perspect	1983	https://conductscience.org/library/papers/6653541	PubMed
6,630,281	Biological activation of 1,3-butadiene to vinyl oxirane by rat liver microsomes and expiration of the reactive metabolite by exposed rats.	J Cancer Res Clin Oncol	1983	https://conductscience.org/library/papers/6630281	PubMed
6,249,238	Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein.	Arch Toxicol	1980	https://conductscience.org/library/papers/6249238	PubMed
2,043,052	Enzyme specific kinetics of 1,2-epoxybutene-3 in microsomes and cytosol from livers of mouse, rat, and man.	Arch Toxicol	1991	https://conductscience.org/library/papers/2043052	PubMed
1,580,790	The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors.	Arch Toxicol	1992	https://conductscience.org/library/papers/1580790	PubMed
885,619	Incubation of 14C-trichloroethylene vapor with rat liver microsomes: uptake of radioactivity and covalent protein binding of metabolites.	Int Arch Occup Environ Health	1977	https://conductscience.org/library/papers/885619	PubMed
612,434	Irreversible binding of chlorinated ethylenes to macromolecules.	Environ Health Perspect	1977	https://conductscience.org/library/papers/612434	PubMed
565,701	Effect of ethanol and vinyl chloride on the induction of liver tumors: preliminary report.	Environ Health Perspect	1977	https://conductscience.org/library/papers/565701	PubMed
485,853	Pharmacokinetics of halogenated ethylenes in rats.	Arch Toxicol	1979	https://conductscience.org/library/papers/485853	PubMed
435,077	Alkylation of RNA by vinyl bromide metabolites in vitro and in vivo.	Arch Toxicol	1979	https://conductscience.org/library/papers/435077	PubMed
373,707	Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.	Arch Toxicol	1979	https://conductscience.org/library/papers/373707	PubMed
330,205	In vitro mutagenicity of the soil nematicide 1,3-dichloropropene.	Experientia	1977	https://conductscience.org/library/papers/330205	PubMed
229,786	Effect of dithiocarb and dimethyl sulfoxide on irreversible binding of 14C-bromobenzene to rat liver microsomal protein.	Arch Toxicol	1979	https://conductscience.org/library/papers/229786	PubMed
157,359	Vinyl chloride and trichloroethylene: comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver.	J Cancer Res Clin Oncol	1979	https://conductscience.org/library/papers/157359	PubMed
25,061	Formation of 3,N4-ethenocytidine moieties in RNA by vinyl chloride metabolities in vitro and in vivo.	Arch Toxicol	1978	https://conductscience.org/library/papers/25061	PubMed

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Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

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ClinicalTrials.govNo license stated
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NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

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ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
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NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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