Paper157359
Vinyl chloride and trichloroethylene: comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver.
Laib RJ and 3 others. J Cancer Res Clin Oncol, 1979. Cited by 32 papers, by iCite.
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ConductScience Library. Vinyl chloride and trichloroethylene: comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver. Papers, record 157359. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/157359
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- Vinyl chloride and trichloroethylene: comparison of alkylating effects of metabolites and induction of preneoplastic enzyme deficiencies in rat liver.
- PubMed
Topics16
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Liver | Major topic |
| Trichloroethylene | Major topic |
| Vinyl Chloride | Major topic |
| Vinyl Compounds | Major topic |
| Adenosine | |
| Adenosine Triphosphatases | |
| Alkylation | |
| Animals | |
| Animals, Newborn | |
| Chromatography, Ion Exchange | |
| Cytidine | |
| Female | |
| Liver Neoplasms | |
| Mitochondria, Liver | |
| RNA | |
| Rats |
Source PubMed
References19
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 426,875 | Reactions of trichloroethylene epoxide in aqueous systems. | Biochem Pharmacol | 1979 | https://conductscience.org/library/papers/426875 | PubMed |
| 2 | 332,116 | Carcinogenicity of trichloroethylene: fact or artifact? | Arch Toxicol | 1977 | https://conductscience.org/library/papers/332116 | PubMed |
| 3 | 4,309,585 | [Histochemical investigations of carcinogenesis in rat liver after time-limited application of diethylnitrosamine]. | Z Krebsforsch | 1969 | https://conductscience.org/library/papers/4309585 | PubMed |
| 4 | 929,626 | Alkylation of RNA by vinyl chloride metabolites in vitro and in vivo: formation of 1-N(6)-etheno-adenosine. | Toxicology | 1977 | https://conductscience.org/library/papers/929626 | PubMed |
| 5 | 1,054,960 | On the possible mechanism of carcinogenic action of vinyl chloride. | Ann N Y Acad Sci | 1975 | https://conductscience.org/library/papers/1054960 | PubMed |
| 6 | 791,581 | Chemical reactivity, biotransformation, and toxicity of polychlorinated aliphatic compounds. | CRC Crit Rev Toxicol | 1976 | https://conductscience.org/library/papers/791581 | PubMed |
| 7 | 578,705 | Irreversible binding of 14C-labelled trichloroethylene to mice liver constituents in vivo and in vitro. | Arch Toxicol | 1977 | https://conductscience.org/library/papers/578705 | PubMed |
| 8 | 885,619 | Incubation of 14C-trichloroethylene vapor with rat liver microsomes: uptake of radioactivity and covalent protein binding of metabolites. | Int Arch Occup Environ Health | 1977 | https://conductscience.org/library/papers/885619 | PubMed |
| 9 | 4,300,123 | [Enzyme histochemical and radioautographic studies during cancerization of the rat liver with diethylnitrosamine]. | Z Krebsforsch | 1968 | https://conductscience.org/library/papers/4300123 | PubMed |
| 10 | 9,709 | Liver microsomal uptake of (14C)vinyl chloride and transformation to protein alkylating metabolites in vitro. | Toxicol Appl Pharmacol | 1976 | https://conductscience.org/library/papers/9709 | PubMed |
| 11 | 4,387,614 | [Enzyme histochemistry studies of adenosine triphosphatase, alkaline and acid phosphatase, as well as succinate dehydrogenase in rat liver parenchyma during the action of the carcinogen diethylnitrosamine]. | Z Naturforsch B | 1968 | https://conductscience.org/library/papers/4387614 | PubMed |
| 13 | 18,130 | Spectral evidence for 2,2,3-trichloro-oxirane formation during microsomal trichloroethylene oxidation. | Arch Toxicol | 1977 | https://conductscience.org/library/papers/18130 | PubMed |
| 14 | 1,108,881 | Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation. | Biochem Pharmacol | 1975 | https://conductscience.org/library/papers/1108881 | PubMed |
| 15 | 1,201,042 | Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride. | Biochem Biophys Res Commun | 1975 | https://conductscience.org/library/papers/1201042 | PubMed |
| 16 | 240,126 | Rat liver microsomes catalyse covalent binding of 14C-vinyl chloride to macromolecules. | Nature | 1975 | https://conductscience.org/library/papers/240126 | PubMed |
| 17 | 612,433 | Recent findings on the carcinogenicity of chlorinated olefins. | Environ Health Perspect | 1977 | https://conductscience.org/library/papers/612433 | PubMed |
| 18 | 25,061 | Formation of 3,N4-ethenocytidine moieties in RNA by vinyl chloride metabolities in vitro and in vivo. | Arch Toxicol | 1978 | https://conductscience.org/library/papers/25061 | PubMed |
| 19 | 4,309,584 | [Histochemical investigations of carcinogenesis in rat liver after continuous application of diethylnitrosamine]. | Z Krebsforsch | 1969 | https://conductscience.org/library/papers/4309584 | PubMed |
| 20 | 1,277,148 | Covalent interaction of metabolites of the carcinogen trichloroethylene in rat hepatic microsomes. | Cancer Res | 1976 | https://conductscience.org/library/papers/1277148 | PubMed |
Cited by9
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 32 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 16,348,039 | Toxicity of Trichloroethylene to Pseudomonas putida F1 Is Mediated by Toluene Dioxygenase. | Appl Environ Microbiol | 1989 | https://conductscience.org/library/papers/16348039 | PubMed |
| 7,791,740 | In vivo effect of vitamin E on serum and tissue glycoprotein levels in perchloroethylene induced cytotoxicity. | Mol Cell Biochem | 1995 | https://conductscience.org/library/papers/7791740 | PubMed |
| 7,283,743 | Formation of pre-neoplastic hepatocellular foci by vinyl fluoride in newborn rats. | Arch Toxicol | 1981 | https://conductscience.org/library/papers/7283743 | PubMed |
| 7,235,993 | Covalent binding of drug metabolites to DNA--a tool of predictive value? | Arch Toxicol | 1980 | https://conductscience.org/library/papers/7235993 | PubMed |
| 6,893,145 | Trichloroethylene vapours do not produce dominant lethal mutations in male mice. | Arch Toxicol | 1980 | https://conductscience.org/library/papers/6893145 | PubMed |
| 6,197,950 | Interactions of trichloroethylene with DNA in vitro and with RNA and DNA of various mouse tissues in vivo. | Arch Toxicol | 1983 | https://conductscience.org/library/papers/6197950 | PubMed |
| 6,152,389 | Trichloroethylene effects on the formation of enzyme-altered foci in rat liver. | Arch Toxicol | 1984 | https://conductscience.org/library/papers/6152389 | PubMed |
| 3,917,197 | Activities of chlorinated ethane and ethylene compounds in the Salmonella/rat microsome mutagenesis and rat hepatocyte/DNA repair assays under vapor phase exposure conditions. | Cell Biol Toxicol | 1985 | https://conductscience.org/library/papers/3917197 | PubMed |
| 533,367 | Formation of pre-neoplastic hepatocellular foci by vinyl bromide in newborn rats. | Arch Toxicol | 1979 | https://conductscience.org/library/papers/533367 | PubMed |
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- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
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- Drugs
- Data
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- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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