Trial · NCT00355368
Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
NCT00355368, Phase 4, Completed, University Hospital, Basel, Switzerland; results first posted 2011-12-15
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care. Trials, record NCT00355368. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00355368
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
- NCT number
- NCT00355368
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 420 participants, actual
- Lead sponsor
- University Hospital, Basel, Switzerland
- Conditions
- Intubation
- Interventions
- Succinylcholine, Rocuronium
- First posted
- 2006-07-21
- Last updated
- 2011-12-15
- Results first posted
- 2011-12-15
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Participants Exhibiting Desaturation >5% | at any time between the start of the intubation sequence and 2min after the completion of intubation | decrease of \>5% in oxygen saturation measured continuously using pulse oxymetry |
| Secondary | Haemodynamic Sequelae of Intubation | between start of induction sequence and 5 min after completion of intubation | any new haemodynamic alteration requiring immediate intervention |
| Secondary | Time to Completion of Intubation | time interval between the injection of the induction agent and the first appearance of endtidal CO2 | time interval between the injection of the induction agent and the first appearance of endtidal CO2 |
| Secondary | Quality of Intubation Conditions Using a Validated Score: Viby-Mogensen et al. Good Clinical Research Practice (GCRP) in Pharmacodynamic Studies of Neuromuscular Blocking Agents. Acta Anaesthesiol Scand 1996;40:59-74. | during laryngoscopy and the first minute after completion of intubation | The factors laryngoscopy, vocal cords, and response to intubation are individually rated with a score from 1 (bad intubation conditions)to 3 (excellent intubation conditions)and the resulting three scores are summed up. The maximum score is thus 9 while the minimum score is 3. Units: measure on a scale |
| Secondary | Number of Participants With an Failed First Intubation Attempts | within the first 90 sec following the start of induction | defined as either uncompleted intubation attempt within 90 sec or starting a second intubation attempt |
Source ClinicalTrials.gov
Outcomes5
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Number of Participants Exhibiting Desaturation >5% | at any time between the start of the intubation sequence and 2min after the completion of intubation | ITT | participants | NUMBER |
| SECONDARY | Haemodynamic Sequelae of Intubation | between start of induction sequence and 5 min after completion of intubation | participants | NUMBER | |
| SECONDARY | Time to Completion of Intubation | time interval between the injection of the induction agent and the first appearance of endtidal CO2 | seconds | MEAN | |
| SECONDARY | Quality of Intubation Conditions Using a Validated Score: Viby-Mogensen et al. Good Clinical Research Practice (GCRP) in Pharmacodynamic Studies of Neuromuscular Blocking Agents. Acta Anaesthesiol Scand 1996;40:59-74. | during laryngoscopy and the first minute after completion of intubation | score points | MEAN | |
| SECONDARY | Number of Participants With an Failed First Intubation Attempts | within the first 90 sec following the start of induction | participants | NUMBER |
Source ClinicalTrials.gov
Results by group8
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Number of Participants Exhibiting Desaturation >5% | Succinylcholine | 73 | participants | ||
| Number of Participants Exhibiting Desaturation >5% | Rocuronium | 66 | participants | ||
| Time to Completion of Intubation | Succinylcholine | 81 | Standard Deviation 38 | seconds | |
| Time to Completion of Intubation | Rocuronium | 95 | Standard Deviation 48 | seconds | |
Quality of Intubation Conditions Using a Validated Score: Viby-Mogensen et al. Good Clinical Research Practice (GCRP) in Pharmacodynamic Studies of Neuromuscular Blocking Agents. Acta Anaesthesiol Scand 1996;40:59-74. | Succinylcholine | 8.3 | Standard Deviation 0.8 | score points | |
Quality of Intubation Conditions Using a Validated Score: Viby-Mogensen et al. Good Clinical Research Practice (GCRP) in Pharmacodynamic Studies of Neuromuscular Blocking Agents. Acta Anaesthesiol Scand 1996;40:59-74. | Rocuronium | 8.2 | Standard Deviation 0.9 | score points | |
| Number of Participants With an Failed First Intubation Attempts | Succinylcholine | 32 | participants | ||
| Number of Participants With an Failed First Intubation Attempts | Rocuronium | 36 | participants |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Succinylcholine | 210 | |
| Overall Study | STARTED | Rocuronium | 210 | |
| Overall Study | COMPLETED | Succinylcholine | 200 | |
| Overall Study | COMPLETED | Rocuronium | 201 | |
| Overall Study | NOT COMPLETED | Succinylcholine | 10 | |
| Overall Study | NOT COMPLETED | Rocuronium | 9 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Succinylcholine | ||
| Total, all-cause mortality | Rocuronium | ||
| Total, other adverse events | Succinylcholine | 0 | 210 |
| Total, other adverse events | Rocuronium | 0 | 210 |
| Total, serious adverse events | Succinylcholine | 0 | 210 |
| Total, serious adverse events | Rocuronium | 0 | 210 |
Source ClinicalTrials.gov
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons3
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Succinylcholine vs Rocuronium: Number of Participants With an Failed First Intubation Attempts | Trial comparisons |
| Succinylcholine vs Rocuronium: Number of Participants Exhibiting Desaturation >5% | Trial comparisons |
| Succinylcholine vs Rocuronium: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00355368
GET https://conductscience.org/api/trials/v1/NCT00355368/registered