Trial · NCT00390546
Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia
NCT00390546, Phase 3, Completed, University of British Columbia; results first posted 2013-08-22
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia. Trials, record NCT00390546. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00390546
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia
- NCT number
- NCT00390546
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 72 participants, actual
- Lead sponsor
- University of British Columbia
- Conditions
- Supraventricular Tachycardia
- Interventions
- Digoxin, Propranolol
- First posted
- 2006-10-20
- Last updated
- 2017-12-13
- Results first posted
- 2013-08-22
- Limitations and caveats
Besides issues of recruitment, potential limitations of this study include the selected dosing for propranol, as a higher dosage is sometimes used, and the lack of dose titration before the 2-month visit, both of which could influence drug efficacy.
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Incidence of Recurrent Supraventricular Tachycardia (SVT) Requiring Medical Intervention to Terminate the Episode. | 6 months or until study endpoints were reached | |
| Secondary | Number of Treated Patients Experiencing First SVT Recurrence | up to 110 days of treatment | Infants treated with propranolol or digoxin |
| Secondary | Incidence of Adverse Outcomes in Infants With Propranolol or Digoxin | 12 months | In relation to the study drugs |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Incidence of Recurrent Supraventricular Tachycardia (SVT) Requiring Medical Intervention to Terminate the Episode. | 6 months or until study endpoints were reached | percentage of participants | NUMBER | |
| SECONDARY | Number of Treated Patients Experiencing First SVT Recurrence | up to 110 days of treatment | participants | NUMBER | |
| SECONDARY | Incidence of Adverse Outcomes in Infants With Propranolol or Digoxin | 12 months | participants | NUMBER |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Incidence of Recurrent Supraventricular Tachycardia (SVT) Requiring Medical Intervention to Terminate the Episode. | Digoxin | 12 | percentage of participants | ||
| Incidence of Recurrent Supraventricular Tachycardia (SVT) Requiring Medical Intervention to Terminate the Episode. | Propranolol | 18 | percentage of participants | ||
| Number of Treated Patients Experiencing First SVT Recurrence | Digoxin | 6 | participants | ||
| Number of Treated Patients Experiencing First SVT Recurrence | Propranolol | 12 | 0.60 to 4.26 | participants | |
| Incidence of Adverse Outcomes in Infants With Propranolol or Digoxin | Digoxin | 0 | participants | ||
| Incidence of Adverse Outcomes in Infants With Propranolol or Digoxin | Propranolol | 0 | participants |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Digoxin | 33 | |
| Overall Study | STARTED | Propranolol | 39 | |
| Overall Study | COMPLETED | Digoxin | 27 | |
| Overall Study | COMPLETED | Propranolol | 34 | |
| Overall Study | NOT COMPLETED | Digoxin | 6 | |
| Overall Study | NOT COMPLETED | Propranolol | 5 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Digoxin | ||
| Total, all-cause mortality | Propranolol | ||
| Total, other adverse events | Digoxin | 0 | 27 |
| Total, other adverse events | Propranolol | 0 | 34 |
| Total, serious adverse events | Digoxin | 0 | 27 |
| Total, serious adverse events | Propranolol | 0 | 34 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 22962431 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons3
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Digoxin vs Propranolol: Number of Treated Patients Experiencing First SVT Recurrence | Trial comparisons |
| Digoxin vs Propranolol: Incidence of Adverse Outcomes in Infants With Propranolol or Digoxin | Trial comparisons |
| Digoxin vs Propranolol: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00390546
GET https://conductscience.org/api/trials/v1/NCT00390546/registered