Trial · NCT00467363
The Effects of Aspirin in Gestation and Reproduction
NCT00467363, Not applicable, Completed, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); results first posted 2014-05-14
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Effects of Aspirin in Gestation and Reproduction. Trials, record NCT00467363. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00467363
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effects of Aspirin in Gestation and Reproduction
- NCT number
- NCT00467363
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 1,228 participants, actual
- Lead sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Conditions
- Birth, Spontaneous Abortion
- Interventions
- acetylsalicylic-acid (aspirin), Folic acid
- First posted
- 2007-04-30
- Last updated
- 2017-02-03
- Results first posted
- 2014-05-14
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Live Birth | after delivery | Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . |
| Secondary | hCG Recognized Pregnancy | within 8-weeks of gestation | |
| Secondary | Clinically Recognized Pregnancy | 8-weeks | |
| Secondary | Early Pregnancy Loss (EPL) | 8 weeks | Implantation failures |
| Secondary | Pregnancy Losses Occurring Less Than 10 Weeks | less than 10-weeks | Includes preembryonic and embryonic losses (exclusive of implantation failures) |
| Secondary | Fetal Pregnancy Loss | until 40 weeks | |
| Secondary | Stillbirth | 40 weeks | |
| Secondary | Ectopic Pregnancy | within 6 weeks | |
| Secondary | Molar Pregnancy | 8 weeks | |
| Secondary | Preeclampsia | until delivery |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes15
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Live Birth | after delivery | Analyses were based on the intention-to-treat principle (excluding participants lost to follow-up). | livebirths | NUMBER |
| SECONDARY | hCG Recognized Pregnancy | within 8-weeks of gestation | pregnancy | NUMBER | |
| SECONDARY | Clinically Recognized Pregnancy | 8-weeks | pregnancy | NUMBER | |
| SECONDARY | Early Pregnancy Loss (EPL) | 8 weeks | pregnancy | NUMBER | |
| SECONDARY | Pregnancy Losses Occurring Less Than 10 Weeks | less than 10-weeks | pregnancy | NUMBER | |
| SECONDARY | Fetal Pregnancy Loss | until 40 weeks | pregnancy | NUMBER | |
| SECONDARY | Stillbirth | 40 weeks | participants | NUMBER | |
| SECONDARY | Ectopic Pregnancy | within 6 weeks | pregnancy | NUMBER | |
| SECONDARY | Molar Pregnancy | 8 weeks | pregnancy | NUMBER | |
| SECONDARY | Preeclampsia | until delivery | participants | NUMBER |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 outcomesResults by group26
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Live Birth | Aspirin | 309 | livebirths | ||
| Live Birth | Placebo | 286 | livebirths | ||
| hCG Recognized Pregnancy | Aspirin | 394 | pregnancy | ||
| hCG Recognized Pregnancy | Placebo | 363 | pregnancy | ||
| Clinically Recognized Pregnancy | Aspirin | 374 | pregnancy | ||
| Clinically Recognized Pregnancy | Placebo | 346 | pregnancy | ||
| Early Pregnancy Loss (EPL) | Aspirin | 28 | pregnancy | ||
| Early Pregnancy Loss (EPL) | Placebo | 27 | pregnancy | ||
| Pregnancy Losses Occurring Less Than 10 Weeks | Aspirin | 56 | pregnancy | ||
| Pregnancy Losses Occurring Less Than 10 Weeks | Placebo | 53 | pregnancy |
1 to 10 of 26Source ClinicalTrials.gov
See all 26 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Aspirin | 615 | |
| Overall Study | STARTED | Placebo | 613 | |
| Overall Study | COMPLETED | Aspirin | 535 | |
| Overall Study | COMPLETED | Placebo | 543 | |
| Overall Study | NOT COMPLETED | Aspirin | 80 | |
| Overall Study | NOT COMPLETED | Placebo | 70 |
Source ClinicalTrials.gov
Adverse events8
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Vaginal Bleeding | Pregnancy, puerperium and perinatal conditions | Aspirin | 24 | 615 | |
| other | Vaginal Bleeding | Pregnancy, puerperium and perinatal conditions | Placebo | 8 | 613 | |
| serious | Transient Pulmonary Hypertension | Pregnancy, puerperium and perinatal conditions | Aspirin | 1 | 615 | 1 |
| serious | Transient Pulmonary Hypertension | Pregnancy, puerperium and perinatal conditions | Placebo | 0 | 613 | 0 |
| serious | Minor Birth Defects | Pregnancy, puerperium and perinatal conditions | Aspirin | 4 | 615 | 4 |
| serious | Minor Birth Defects | Pregnancy, puerperium and perinatal conditions | Placebo | 4 | 613 | 4 |
| serious | Neonatal Death | Pregnancy, puerperium and perinatal conditions | Aspirin | 2 | 615 | 2 |
| serious | Neonatal Death | Pregnancy, puerperium and perinatal conditions | Placebo | 1 | 613 | 1 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Aspirin | ||
| Total, all-cause mortality | Placebo | ||
| Total, other adverse events | Aspirin | 24 | 615 |
| Total, other adverse events | Placebo | 8 | 613 |
| Total, serious adverse events | Aspirin | 7 | 615 |
| Total, serious adverse events | Placebo | 5 | 613 |
Source ClinicalTrials.gov
Papers42
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons4
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Aspirin vs Placebo: Stillbirth | Trial comparisons |
| Aspirin vs Placebo: Preeclampsia | Trial comparisons |
| Aspirin vs Placebo: Abruption | Trial comparisons |
| Aspirin vs Placebo: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00467363
GET https://conductscience.org/api/trials/v1/NCT00467363/results?page=2