Trial · NCT00683124
Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients
NCT00683124, Phase 3, Unknown, Fondazione IRCCS Policlinico San Matteo di Pavia
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients. Trials, record NCT00683124. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00683124
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients
- NCT number
- NCT00683124
- Status
- Unknown
- Phases
- Phase 3
- Enrollment
- 291 participants, estimated
- Lead sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
- Conditions
- Marfan Syndrome
- Interventions
- Losartan and nebivolol, Losartan, Nebivolol
- First posted
- 2008-05-23
- Last updated
- 2011-07-22
- Other registries' IDs
- eudract:2008-001462-81
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | BSA and age-adjusted aortic root diameter (sinuses of Valsalva) | every 12 months | |
| Secondary | The pharmacokinetics of the two drugs by age and dosages | every 12 months | |
| Secondary | Comparative evaluation of the serum levels of total and active TGFb | every 12 months | |
| Secondary | Quantitative assessment of the expression of the mutated gene (FBN1, both 5' and 3') | every 12 months | |
| Secondary | Pharmacogenetic bases of drug responsiveness (Losartan: CYP2C9 gene) (Nebivolol: CYP2D6 gene) | every 12 months | |
| Secondary | Aortic valve regurgitation severity | every 12 months | |
| Secondary | Left ventricular end-diastolic diameter | every 12 months | |
| Secondary | Left ventricular ejection fraction | every 12 months | |
| Secondary | Spirometric lung volumes and flows | every 12 months | |
| Secondary | QoL evaluation basing on SF-36 questionnaire | every 12 months |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers15
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00683124
GET https://conductscience.org/api/trials/v1/NCT00683124/registered