Trial · NCT00901628
Periarticular Multimodal Drug Injections in Total Knee Arthroplasty
NCT00901628, Phase 4, Completed, Seoul National University Hospital; results first posted 2013-01-25
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Periarticular Multimodal Drug Injections in Total Knee Arthroplasty. Trials, record NCT00901628. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT00901628
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Periarticular Multimodal Drug Injections in Total Knee Arthroplasty
- NCT number
- NCT00901628
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 101 participants, actual
- Lead sponsor
- Seoul National University Hospital
- Conditions
- Osteoarthritis, Knee
- Interventions
- ropivacaine, morphine sulfate, ketorolac, epinephrine, cefuroxime
- First posted
- 2009-05-14
- Last updated
- 2013-01-25
- Results first posted
- 2013-01-25
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Pain( Visual Analog Scale ) | the night after surgery | An independent investigator who was blinded to randomization assessed pain level using 0 to 10 visual analog scale (VAS) that ranged from 0 (no pain) to 10 (worst imaginable pain)at the night after operation. |
| Secondary | Intravenous Patient Controlled Analgesia(PCA) Consumption During 24 Hours After Surgery | 24 hours postoperative | Fentanyl based PCA consumption via PCA pump (microgram) |
| Secondary | Participant Number of Postoperative Nausea and Vomiting During 24 Hours After Surgery | 24 hours after surgery | An independent investigator assessed participant number of postoperative nausea and vomiting during 24 hours after surgery. Nausea was defined as a subjective unpleasant sensation associated with awareness of the urge to vomit; and vomiting, as the forceful expulsion of gastric contents from the mouth. |
| Secondary | the Proportion of Patients Who Were Satisfied With the Pain Management | postoperative 7 day | |
| Secondary | The Proportion of Patients Who Could Raise Leg With Replaced Knee Extended | 24 hours postoperative | |
| Secondary | Maximal Flexion Angle Degree on Postoperative 7 Day | postoperative 7 day | An independent investigator measured the maximal flexion angle (degree) of replaced knee with 28 centimeter armed goniometer on postoperative 7 day |
Source ClinicalTrials.gov
Outcomes6
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Pain( Visual Analog Scale ) | the night after surgery | units on a scale | MEAN | |
| SECONDARY | Intravenous Patient Controlled Analgesia(PCA) Consumption During 24 Hours After Surgery | 24 hours postoperative | microgram | MEAN | |
| SECONDARY | Participant Number of Postoperative Nausea and Vomiting During 24 Hours After Surgery | 24 hours after surgery | participants | NUMBER | |
| SECONDARY | the Proportion of Patients Who Were Satisfied With the Pain Management | postoperative 7 day | participants | NUMBER | |
| SECONDARY | The Proportion of Patients Who Could Raise Leg With Replaced Knee Extended | 24 hours postoperative | participants | NUMBER | |
| SECONDARY | Maximal Flexion Angle Degree on Postoperative 7 Day | postoperative 7 day | degree | MEAN |
Source ClinicalTrials.gov
Results by group12
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Pain( Visual Analog Scale ) | Periarticular Injection Group | 2.3 | Standard Deviation 3.2 | units on a scale | |
| Pain( Visual Analog Scale ) | No Injection Group | 6.4 | Standard Deviation 3.4 | units on a scale | |
| Intravenous Patient Controlled Analgesia(PCA) Consumption During 24 Hours After Surgery | Periarticular Injection Group | 169.4 | Standard Deviation 273.9 | microgram | |
| Intravenous Patient Controlled Analgesia(PCA) Consumption During 24 Hours After Surgery | No Injection Group | 262.3 | Standard Deviation 200.2 | microgram | |
| Participant Number of Postoperative Nausea and Vomiting During 24 Hours After Surgery | Periarticular Injection Group | 22 | participants | ||
| Participant Number of Postoperative Nausea and Vomiting During 24 Hours After Surgery | No Injection Group | 15 | participants | ||
| the Proportion of Patients Who Were Satisfied With the Pain Management | Periarticular Injection Group | 38 | participants | ||
| the Proportion of Patients Who Were Satisfied With the Pain Management | No Injection Group | 39 | participants | ||
| The Proportion of Patients Who Could Raise Leg With Replaced Knee Extended | Periarticular Injection Group | 18 | participants | ||
| The Proportion of Patients Who Could Raise Leg With Replaced Knee Extended | No Injection Group | 6 | participants |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Periarticular Injection Group | 49 | |
| Overall Study | STARTED | No Injection Group | 52 | |
| Overall Study | COMPLETED | Periarticular Injection Group | 45 | |
| Overall Study | COMPLETED | No Injection Group | 42 | |
| Overall Study | NOT COMPLETED | Periarticular Injection Group | 4 | |
| Overall Study | NOT COMPLETED | No Injection Group | 10 |
Source ClinicalTrials.gov
Adverse events2
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | participant number of postoperative wound infection | Musculoskeletal and connective tissue disorders | Periarticular Injection Group | 0 | 49 | 0 |
| serious | participant number of postoperative wound infection | Musculoskeletal and connective tissue disorders | No Injection Group | 0 | 52 | 0 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Periarticular Injection Group | ||
| Total, all-cause mortality | No Injection Group | ||
| Total, other adverse events | Periarticular Injection Group | 0 | 49 |
| Total, other adverse events | No Injection Group | 0 | 52 |
| Total, serious adverse events | Periarticular Injection Group | 0 | 49 |
| Total, serious adverse events | No Injection Group | 0 | 52 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons4
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Periarticular Injection Group vs No Injection Group: Participant Number of Postoperative Nausea and Vomiting During 24 Hours After Surgery | Trial comparisons |
| Periarticular Injection Group vs No Injection Group: The Proportion of Patients Who Could Raise Leg With Replaced Knee Extended | Trial comparisons |
| Periarticular Injection Group vs No Injection Group: the Proportion of Patients Who Were Satisfied With the Pain Management | Trial comparisons |
| Periarticular Injection Group vs No Injection Group: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT00901628
GET https://conductscience.org/api/trials/v1/NCT00901628/registered