Trial · NCT01949233
The Oxford Marfan Trial
NCT01949233, Phase 2, Unknown, University of Oxford
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Oxford Marfan Trial. Trials, record NCT01949233. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01949233
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Oxford Marfan Trial
- NCT number
- NCT01949233
- Status
- Unknown
- Phases
- Phase 2
- Enrollment
- 56 participants, estimated
- Lead sponsor
- University of Oxford
- Conditions
- Marfan Syndrome
- Interventions
- Irbesartan 150-300mg capsules daily for 6 months, Doxycycline 100-200mg capsules daily for 6 months, Doxycycline placebo capsules daily for 6 months, Irbesartan placebo capsules daily for 6 months
- First posted
- 2013-09-24
- Last updated
- 2015-06-09
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change (i.e. difference between first and last study visits) in aortic distensibility in the ascending aorta between allocation arms measured using CMR | 0 months and 6 months | |
| Secondary | 1. Change in aortic distensibility in the proximal and distal descending aorta between allocation arms measured using CMR | 0 and 6 months | |
| Secondary | 2. Change in aortic dimensions in the proximal and distal descending aorta | 0 and 6 months | |
| Secondary | 3. Change in mean and peak axial and mean and peak circumferential aortic wall shear stress between allocation arms estimated by CMR using a 4D flow sequence | 0 and 6 months | |
| Secondary | 4. Change in peripheral (brachial) blood pressure between allocation arms measured using a calibrated, validated automated sphygmomanometer | 0 and 6 months | |
| Secondary | 5. Change in central blood pressure, and augmentation index between allocation arms measured by applanation tonometry and by oscillometric sphygmomanometry | 0 and 6 months | |
| Secondary | 6. Change in left ventricular volumes, mass and systolic function between allocation arms to placebo measured by CMR | 0 and 6 months | |
| Secondary | 7. Change in aortic pulse wave velocity between allocation arms measured by CMR | 0 and 6 months | |
| Secondary | 8. Change in carotid-femoral pulse wave velocity between allocation arms compared to placebo measured by applanation tonometry | 0 and 6 months | |
| Secondary | 9. Change in TGF-β level, or other biomarker, between allocation arms compared to placebo | 0 and 6 months |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01949233
GET https://conductscience.org/api/trials/v1/NCT01949233/registered