Trial · NCT01949233
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 12 of 12
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change (i.e. difference between first and last study visits) in aortic distensibility in the ascending aorta between allocation arms measured using CMR | 0 months and 6 months | |
| Secondary | 1. Change in aortic distensibility in the proximal and distal descending aorta between allocation arms measured using CMR | 0 and 6 months | |
| Secondary | 2. Change in aortic dimensions in the proximal and distal descending aorta | 0 and 6 months | |
| Secondary | 3. Change in mean and peak axial and mean and peak circumferential aortic wall shear stress between allocation arms estimated by CMR using a 4D flow sequence | 0 and 6 months | |
| Secondary | 4. Change in peripheral (brachial) blood pressure between allocation arms measured using a calibrated, validated automated sphygmomanometer | 0 and 6 months | |
| Secondary | 5. Change in central blood pressure, and augmentation index between allocation arms measured by applanation tonometry and by oscillometric sphygmomanometry | 0 and 6 months | |
| Secondary | 6. Change in left ventricular volumes, mass and systolic function between allocation arms to placebo measured by CMR | 0 and 6 months | |
| Secondary | 7. Change in aortic pulse wave velocity between allocation arms measured by CMR | 0 and 6 months | |
| Secondary | 8. Change in carotid-femoral pulse wave velocity between allocation arms compared to placebo measured by applanation tonometry | 0 and 6 months | |
| Secondary | 9. Change in TGF-β level, or other biomarker, between allocation arms compared to placebo | 0 and 6 months | |
| Secondary | 10. Tolerability and safety of irbesartan and doxycycline, assessed by incidence of adverse reactions and change in health status score, using the SF-36 questionnaire | 0, 0.5 and 6 months | |
| Secondary | 11. Document the frequency of aortic dissection, death from cardiovascular causes, or need for aortic root or valve surgery (if any) in each allocation arm | 0-6 months |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
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GET https://conductscience.org/api/trials/v1/NCT01949233/registered