Trial · NCT02507505

Regional Versus General Anesthesia for Promoting Independence After Hip Fracture

NCT02507505, Not applicable, Completed, University of Pennsylvania; results first posted 2024-05-13

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Regional Versus General Anesthesia for Promoting Independence After Hip Fracture. Trials, record NCT02507505. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02507505

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Regional Versus General Anesthesia for Promoting Independence After Hip Fracture
NCT number: NCT02507505
Status: Completed
Phases: Not applicable
Enrollment: 1,848 participants, actual
Lead sponsor: University of Pennsylvania
Conditions: Hip Fractures
Interventions: Regional Anesthesia, General Anesthesia
First posted: 2015-07-24
Last updated: 2024-05-13
Results first posted: 2024-05-13

Source ClinicalTrials.gov

Registered outcomes12

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Death or Inability to Walk 10 Feet or Across a Room Without Human Assistance	Approximately 60 days after Randomization	Will be assessed via telephone interview
Secondary	Overall Health and Disability	Approximately 60, 180, and 365 days after randomization	Will be assessed via the 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0). The 12-item WHODAS 2.0 scale measures disability in six functional domains (cognition, mobility, self-care, social interaction, life activities, and community participation). Scores range from 0 to 100, with lower scores indicating lower degrees of disability.
Secondary	Ability to Return to Home	Approximately 60, 180, and 365 days after randomization	Will be assessed via telephone interview. Measure assessed as death or new transition to nursing home residence at each time point.
Secondary	Chronic Pain	Approximately 60, 180, and 365 days after randomization	Will be assessed via the Numeric Rating Scale (NRS) and the need for prescription medications as evaluated during telephone interview. NRS values range from 0 to 10, with higher values indicating greater pain.
Secondary	Cognitive Function	Baseline and approximately 60, 180, and 365 days after randomization	Will be assessed via Short Blessed Test (SBT); SBT values range from 0 to 28, with higher scores indicating greater degrees of cognitive impairment.
Secondary	All-cause Mortality	Approximately 60, 180, and 365 days after randomization	Will be assessed via telephone interview and National Death Index (NDI) search
Secondary	Need for Assistive Devices for Walking	Approximately 60, 180, and 365 days after randomization	Will be assessed via telephone interview
Secondary	Acute Postoperative Pain	Before surgery and daily through postoperative day 3 or day of discharge, whichever occurs first	Will be assessed via in-person interview using numeric rating scale (NRS). NRS values range from 0 to 10, with greater values indicating worse pain.
Secondary	Satisfaction With Care	Postoperative day 3 or day of discharge, whichever occurs first	Will be assessed via Bauer Patient Satisfaction Questionnaire. Data reported here corresponds to a response of "dissatisfied" or "very dissatisfied" to one or more of 5 Bauer questionnaire items assessing the following domains: information given by anesthesiologist before surgery; waking up from anesthesia; pain therapy after surgery; treatment of nausea and vomiting after surgery; care provided by department of anesthesia in general.
Secondary	Postoperative Delirium	Baseline and daily through postoperative day 3 or day of discharge, whichever occurs first	Will be assessed via 3-minute Diagnostic Interview for Confusion Assessment Method (3D-CAM) assessment tool. Any positive 3D-CAM screen over the first 3 postoperative days in a patient with a negative pre-randomization screen was counted as a case of incident delirium.

1 to 10 of 12Source ClinicalTrials.gov

See all 12 registered outcomes

Outcomes12

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Death or Inability to Walk 10 Feet or Across a Room Without Human Assistance	Approximately 60 days after Randomization		Participants	COUNT_OF_PARTICIPANTS
SECONDARY	Overall Health and Disability	Approximately 60, 180, and 365 days after randomization	Patients providing data at each time point	score on a scale	MEDIAN
SECONDARY	Ability to Return to Home	Approximately 60, 180, and 365 days after randomization	This outcome was assessed among patients who were not admitted from a nursing home, rehabilitation facility, or acute care hospital. Denominator includes all known decedents at each time point, plus survivors providing information on location of residence at the time of study interview.	Participants	COUNT_OF_PARTICIPANTS
SECONDARY	Chronic Pain	Approximately 60, 180, and 365 days after randomization	Numbers differ across rows due to missing data	units on a scale	MEAN
SECONDARY	Cognitive Function	Baseline and approximately 60, 180, and 365 days after randomization	Numbers differ across rows due to missing data	units on a scale	MEDIAN
SECONDARY	All-cause Mortality	Approximately 60, 180, and 365 days after randomization	All enrolled patients who had not withdrawn or been lost to follow up a given study time point	participants	NUMBER
SECONDARY	Need for Assistive Devices for Walking	Approximately 60, 180, and 365 days after randomization	60-day outcome	Participants	COUNT_OF_PARTICIPANTS
SECONDARY	Acute Postoperative Pain	Before surgery and daily through postoperative day 3 or day of discharge, whichever occurs first		units on a scale	MEAN
SECONDARY	Satisfaction With Care	Postoperative day 3 or day of discharge, whichever occurs first		Participants	COUNT_OF_PARTICIPANTS
SECONDARY	Postoperative Delirium	Baseline and daily through postoperative day 3 or day of discharge, whichever occurs first	This outcome was assessed only among patients who had a negative 3D-CAM assessment for delirium before randomization.	Participants	COUNT_OF_PARTICIPANTS

1 to 10 of 12Source ClinicalTrials.gov

See all 12 outcomes

Results by group52

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Death or Inability to Walk 10 Feet or Across a Room Without Human Assistance	Regional Anesthesia		132		Participants
Death or Inability to Walk 10 Feet or Across a Room Without Human Assistance	General Anesthesia		132		Participants
Overall Health and Disability	Regional Anesthesia	60-day outcome	22.7	Inter-Quartile Range 8.3 to 43.2	score on a scale
Overall Health and Disability	General Anesthesia	60-day outcome	18.2	Inter-Quartile Range 6.3 to 31.8	score on a scale
Overall Health and Disability	Regional Anesthesia	180-day outcome	10.4	Inter-Quartile Range 2.3 to 27.1	score on a scale
Overall Health and Disability	General Anesthesia	180-day outcome	10.4	Inter-Quartile Range 2.1 to 27.3	score on a scale
Overall Health and Disability	Regional Anesthesia	365-day outcome	10.4	Inter-Quartile Range 2.1 to 29.2	score on a scale
Overall Health and Disability	General Anesthesia	365-day outcome	8.3	Inter-Quartile Range 0 to 22.9	score on a scale
Ability to Return to Home	Regional Anesthesia	60-day outcomes	108		Participants
Ability to Return to Home	General Anesthesia	60-day outcomes	114		Participants

1 to 10 of 52Source ClinicalTrials.gov

See all 52 results by group

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Regional Anesthesia	795
Overall Study	STARTED	General Anesthesia	805
Overall Study	COMPLETED	Regional Anesthesia	712
Overall Study	COMPLETED	General Anesthesia	733
Overall Study	NOT COMPLETED	Regional Anesthesia	83
Overall Study	NOT COMPLETED	General Anesthesia	72

Source ClinicalTrials.gov

Adverse events886

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Anemia	Blood and lymphatic system disorders	Regional Anesthesia	73	795
other	Anemia	Blood and lymphatic system disorders	General Anesthesia	75	805
other	Anemia iron deficiency	Blood and lymphatic system disorders	Regional Anesthesia	0	795
other	Anemia iron deficiency	Blood and lymphatic system disorders	General Anesthesia	1	805
other	Hemolysis	Blood and lymphatic system disorders	Regional Anesthesia	1	795
other	Hemolysis	Blood and lymphatic system disorders	General Anesthesia	0	805
other	Hemolytic uremic syndrome	Blood and lymphatic system disorders	Regional Anesthesia	0	795
other	Hemolytic uremic syndrome	Blood and lymphatic system disorders	General Anesthesia	1	805
other	Hypoplastic marrow	Blood and lymphatic system disorders	Regional Anesthesia	0	795
other	Hypoplastic marrow	Blood and lymphatic system disorders	General Anesthesia	1	805

1 to 10 of 886Source ClinicalTrials.gov

See all 886 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Regional Anesthesia	98	795
Total, all-cause mortality	General Anesthesia	92	805
Total, other adverse events	Regional Anesthesia	278	795
Total, other adverse events	General Anesthesia	286	805
Total, serious adverse events	Regional Anesthesia	255	795
Total, serious adverse events	General Anesthesia	242	805

Source ClinicalTrials.gov

Papers5

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
27852723	DERIVED	PubMed
28982261	DERIVED	PubMed
34623788	DERIVED	PubMed
35696684	DERIVED	PubMed
37365614	DERIVED	PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons7

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Regional Anesthesia vs General Anesthesia: Inpatient Mortality	Trial comparisons
Regional Anesthesia vs General Anesthesia: Satisfaction With Care	Trial comparisons
Regional Anesthesia vs General Anesthesia: Postoperative Delirium	Trial comparisons
Regional Anesthesia vs General Anesthesia: Major Inpatient Morbidity	Trial comparisons
Regional Anesthesia vs General Anesthesia: Death or Inability to Walk 10 Feet or Across a Room Without Human Assistance	Trial comparisons
Regional Anesthesia vs General Anesthesia: deaths from any cause	Trial comparisons
Regional Anesthesia vs General Anesthesia: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT02507505

GET https://conductscience.org/api/trials/v1/NCT02507505/results?page=2

API reference For AI assistants