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Trial · NCT03175367

Results by group81

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Percent Change From Baseline in Calculated Low Density Lipoprotein Cholesterol (LDL-C) at Week 16 (Intent-to-Treat [ITT] Estimand)Group A: Placebo SC QW (DBTP)8.8Standard Error 6.4Percent Change
Percent Change From Baseline in Calculated Low Density Lipoprotein Cholesterol (LDL-C) at Week 16 (Intent-to-Treat [ITT] Estimand)Group A: Evinacumab 300 mg SC Q2W (DBTP)-29.7Standard Error 6.4Percent Change
Percent Change From Baseline in Calculated Low Density Lipoprotein Cholesterol (LDL-C) at Week 16 (Intent-to-Treat [ITT] Estimand)Group A: Evinacumab 300 mg SC QW (DBTP)-44.0Standard Error 6.3Percent Change
Percent Change From Baseline in Calculated Low Density Lipoprotein Cholesterol (LDL-C) at Week 16 (Intent-to-Treat [ITT] Estimand)Group A: Evinacumab 450 mg SC QW (DBTP)-47.2Standard Error 6.2Percent Change
Percent Change From Baseline in Calculated Low Density Lipoprotein Cholesterol (LDL-C) at Week 16 (Intent-to-Treat [ITT] Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)0.6Standard Error 6.6Percent Change
Percent Change From Baseline in Calculated Low Density Lipoprotein Cholesterol (LDL-C) at Week 16 (Intent-to-Treat [ITT] Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)-23.5Standard Error 6.6Percent Change
Percent Change From Baseline in Calculated Low Density Lipoprotein Cholesterol (LDL-C) at Week 16 (Intent-to-Treat [ITT] Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)-49.9Standard Error 6.1Percent Change
Percent Change From Baseline in Apolipoprotein B (Apo B) at Week 16 (ITT Estimand)Group A: Placebo SC QW (DBTP)6.7Standard Error 5.1Percent Change
Percent Change From Baseline in Apolipoprotein B (Apo B) at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC Q2W (DBTP)-19.9Standard Error 5.1Percent Change
Percent Change From Baseline in Apolipoprotein B (Apo B) at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC QW (DBTP)-35.2Standard Error 5.1Percent Change
Percent Change From Baseline in Apolipoprotein B (Apo B) at Week 16 (ITT Estimand)Group A: Evinacumab 450 mg SC QW (DBTP)-38.8Standard Error 4.9Percent Change
Percent Change From Baseline in Apolipoprotein B (Apo B) at Week 16 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)-3.8Standard Error 4.7Percent Change
Percent Change From Baseline in Apolipoprotein B (Apo B) at Week 16 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)-20.4Standard Error 4.6Percent Change
Percent Change From Baseline in Apolipoprotein B (Apo B) at Week 16 (ITT Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)-43.2Standard Error 4.3Percent Change
Percent Change From Baseline in Apo B at Week 24 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)5.9Standard Error 6.0Percent Change
Percent Change From Baseline in Apo B at Week 24 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)-15.9Standard Error 5.9Percent Change
Percent Change From Baseline in Apo B at Week 24 (ITT Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)-34.5Standard Error 5.6Percent Change
Percent Change From Baseline in Non High Density Lipoprotein Cholesterol (Non-HDL-C) at Week 16 (ITT Estimand)Group A: Placebo SC QW (DBTP)8.0Standard Error 5.4Percent Change
Percent Change From Baseline in Non High Density Lipoprotein Cholesterol (Non-HDL-C) at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC Q2W (DBTP)-31.3Standard Error 5.4Percent Change
Percent Change From Baseline in Non High Density Lipoprotein Cholesterol (Non-HDL-C) at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC QW (DBTP)-45.8Standard Error 5.3Percent Change

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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