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Trial · NCT03175367

Results by group81

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Percent Change From Baseline in Non High Density Lipoprotein Cholesterol (Non-HDL-C) at Week 16 (ITT Estimand)Group A: Evinacumab 450 mg SC QW (DBTP)-50.6Standard Error 5.2Percent Change
Percent Change From Baseline in Non High Density Lipoprotein Cholesterol (Non-HDL-C) at Week 16 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)-1.1Standard Error 5.8Percent Change
Percent Change From Baseline in Non High Density Lipoprotein Cholesterol (Non-HDL-C) at Week 16 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)-24.8Standard Error 5.7Percent Change
Percent Change From Baseline in Non High Density Lipoprotein Cholesterol (Non-HDL-C) at Week 16 (ITT Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)-52.0Standard Error 5.3Percent Change
Percent Change From Baseline in Non-HDL-C at Week 24 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)10.4Standard Error 7.0Percent Change
Percent Change From Baseline in Non-HDL-C at Week 24 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)-20.2Standard Error 6.7Percent Change
Percent Change From Baseline in Non-HDL-C at Week 24 (ITT Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)-44.3Standard Error 6.4Percent Change
Percentage of Participants With >= 30% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group A: Placebo SC QW (DBTP)11.3Percentage of Participants
Percentage of Participants With >= 30% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC Q2W (DBTP)68.1Percentage of Participants
Percentage of Participants With >= 30% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC QW (DBTP)73.9Percentage of Participants
Percentage of Participants With >= 30% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group A: Evinacumab 450 mg SC QW (DBTP)71.4Percentage of Participants
Percentage of Participants With >= 30% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)15.5Percentage of Participants
Percentage of Participants With >= 30% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)57.9Percentage of Participants
Percentage of Participants With >= 30% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)86.8Percentage of Participants
Percentage of Participants With >= 50% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group A: Placebo SC QW (DBTP)5.2Percentage of Participants
Percentage of Participants With >= 50% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC Q2W (DBTP)28.6Percentage of Participants
Percentage of Participants With >= 50% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC QW (DBTP)53.7Percentage of Participants
Percentage of Participants With >= 50% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group A: Evinacumab 450 mg SC QW (DBTP)60.6Percentage of Participants
Percentage of Participants With >= 50% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)12.3Percentage of Participants
Percentage of Participants With >= 50% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)24.6Percentage of Participants

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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