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Trial · NCT03175367

Results by group81

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Percentage of Participants With >= 50% Reduction in Calculated LDL-C at Week 16 (ITT Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)63.2Percentage of Participants
Percentage of Participants With Calculated LDL-C < 50 mg/dL (1.30 mmol/L) at Week 16 (ITT Estimand)Group A: Placebo SC QW (DBTP)5.1Percentage of Participants
Percentage of Participants With Calculated LDL-C < 50 mg/dL (1.30 mmol/L) at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC Q2W (DBTP)22.8Percentage of Participants
Percentage of Participants With Calculated LDL-C < 50 mg/dL (1.30 mmol/L) at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC QW (DBTP)29.7Percentage of Participants
Percentage of Participants With Calculated LDL-C < 50 mg/dL (1.30 mmol/L) at Week 16 (ITT Estimand)Group A: Evinacumab 450 mg SC QW (DBTP)40.8Percentage of Participants
Percentage of Participants With Calculated LDL-C < 50 mg/dL (1.30 mmol/L) at Week 16 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)9.3Percentage of Participants
Percentage of Participants With Calculated LDL-C < 50 mg/dL (1.30 mmol/L) at Week 16 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)13.2Percentage of Participants
Percentage of Participants With Calculated LDL-C < 50 mg/dL (1.30 mmol/L) at Week 16 (ITT Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)39.5Percentage of Participants
Percent Change From Baseline in Calculated LDL-C at Week 24 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)14.8Standard Error 8.3Percent Change
Percent Change From Baseline in Calculated LDL-C at Week 24 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)-17.7Standard Error 8.0Percent Change
Percent Change From Baseline in Calculated LDL-C at Week 24 (ITT Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)-39.7Standard Error 7.7Percent Change
Percent Change From Baseline in Total Cholesterol (TC) at Week 16 (ITT Estimand)Group A: Placebo SC QW (DBTP)6.1Standard Error 4.0Percent Change
Percent Change From Baseline in Total Cholesterol (TC) at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC Q2W (DBTP)-31.0Standard Error 4.0Percent Change
Percent Change From Baseline in Total Cholesterol (TC) at Week 16 (ITT Estimand)Group A: Evinacumab 300 mg SC QW (DBTP)-40.3Standard Error 4.0Percent Change
Percent Change From Baseline in Total Cholesterol (TC) at Week 16 (ITT Estimand)Group A: Evinacumab 450 mg SC QW (DBTP)-45.4Standard Error 3.9Percent Change
Percent Change From Baseline in Total Cholesterol (TC) at Week 16 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)-0.4Standard Error 4.5Percent Change
Percent Change From Baseline in Total Cholesterol (TC) at Week 16 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)-22.6Standard Error 4.4Percent Change
Percent Change From Baseline in Total Cholesterol (TC) at Week 16 (ITT Estimand)Group B: Evinacumab 15 mg/kg IV Q4W (DBTP to OLTP)-46.8Standard Error 4.1Percent Change
Percent Change From Baseline in Total Cholesterol at Week 24 (ITT Estimand)Group B: Placebo IV Q4W (DBTP to OLTP)8.5Standard Error 5.1Percent Change
Percent Change From Baseline in Total Cholesterol at Week 24 (ITT Estimand)Group B: Evinacumab 5 mg/kg IV Q4W (DBTP to OLTP)-19.9Standard Error 4.9Percent Change

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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