Trial · NCT03222570

An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression

NCT03222570, Phase 2, Completed, University of Minnesota; results first posted 2025-07-02

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression. Trials, record NCT03222570. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03222570

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression
NCT number: NCT03222570
Status: Completed
Phases: Phase 2
Enrollment: 90 participants, actual
Lead sponsor: University of Minnesota
Conditions: Depressive Disorder
Interventions: Interpersonal Psychotherapy for Depressed Adolescents, Selective Serotonin Reuptake Inhibitor, Usual Care
First posted: 2017-07-19
Last updated: 2025-07-02
Results first posted: 2025-07-02

Source ClinicalTrials.gov

Registered outcomes2

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Children's Depression Rating Scale - Revised	16 weeks	Minimum value: 17 Maximum value: 113 Higher scores indicate worse outcome
Secondary	Children's Global Assessment Scale	16 weeks	Measure of general psychosocial functioning Minimum score: 1 Maximum score: 100 A higher score indicates a better outcome

Source ClinicalTrials.gov

Outcomes2

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Children's Depression Rating Scale - Revised	16 weeks		score on a scale	MEAN
SECONDARY	Children's Global Assessment Scale	16 weeks		score on a scale	MEAN

Source ClinicalTrials.gov

Results by group4

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Children's Depression Rating Scale - Revised	IPT-A Adaptive Treatment Strategy	36.0	Standard Deviation 11.3	score on a scale
Children's Depression Rating Scale - Revised	Usual Care	37.5	Standard Deviation 11.7	score on a scale
Children's Global Assessment Scale	IPT-A Adaptive Treatment Strategy	61.8	Standard Deviation 9.5	score on a scale
Children's Global Assessment Scale	Usual Care	63.3	Standard Deviation 12.1	score on a scale

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	IPT-A Adaptive Treatment Strategy	57
Overall Study	STARTED	Usual Care	33
Overall Study	COMPLETED	IPT-A Adaptive Treatment Strategy	40
Overall Study	COMPLETED	Usual Care	27
Overall Study	NOT COMPLETED	IPT-A Adaptive Treatment Strategy	17
Overall Study	NOT COMPLETED	Usual Care	6

Source ClinicalTrials.gov

Adverse events2

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Emergent or worsening suicidal ideation	Psychiatric disorders	IPT-A Adaptive Treatment Strategy	10	57
other	Emergent or worsening suicidal ideation	Psychiatric disorders	Usual Care	5	33

Source ClinicalTrials.gov

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	IPT-A Adaptive Treatment Strategy	0	57
Total, all-cause mortality	Usual Care	0	33
Total, other adverse events	IPT-A Adaptive Treatment Strategy	10	57
Total, other adverse events	Usual Care	5	33
Total, serious adverse events	IPT-A Adaptive Treatment Strategy	0	57
Total, serious adverse events	Usual Care	0	33

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
R01MH113748	An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression	GUNLICKS-STOESSEL, MEREDITH LYN	UNIVERSITY OF MINNESOTA	NATIONAL INSTITUTE OF MENTAL HEALTH	2017 to 2021

Source NIH RePORTER

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
IPT-A Adaptive Treatment Strategy vs Usual Care: deaths from any cause	Trial comparisons
IPT-A Adaptive Treatment Strategy vs Usual Care: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03222570

GET https://conductscience.org/api/trials/v1/NCT03222570/registered

API reference For AI assistants