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Trial · NCT03223337

Results by group540

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK1278863296.2407Geometric Coefficient of Variation 111.1Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK1278863148.3225Geometric Coefficient of Variation 31.7Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2391220 (M2)77.6352Geometric Coefficient of Variation 56.9Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2391220 (M2)47.1340Geometric Coefficient of Variation 30.9Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2487818 (M4)47.5557Geometric Coefficient of Variation 67.4Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2487818 (M4)28.9896Geometric Coefficient of Variation 30.3Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2506102 (M5)16.8212Geometric Coefficient of Variation 43.9Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2506102 (M5)11.2658Geometric Coefficient of Variation 29.4Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2506104 (M3)NAGeometric Coefficient of Variation NAHour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2506104 (M3)NAGeometric Coefficient of Variation NAHour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2531398 (M6)33.9398Geometric Coefficient of Variation 49.2Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2531398 (M6)20.9224Geometric Coefficient of Variation 27.7Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2531401 (M13)52.0606Geometric Coefficient of Variation 34.0Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) Extrapolated to Infinite Time (AUC [0-infinity]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2531401 (M13)39.6044Geometric Coefficient of Variation 32.1Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK1278863299.8773Geometric Coefficient of Variation 39.9Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK1278863205.7559Geometric Coefficient of Variation 37.2Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2391220 (M2)91.3799Geometric Coefficient of Variation 44.7Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2391220 (M2)47.1647Geometric Coefficient of Variation 26.9Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2487818 (M4)63.6211Geometric Coefficient of Variation 40.1Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2487818 (M4)31.7637Geometric Coefficient of Variation 28.4Hour*nanogram per milliliter

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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