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Trial · NCT03223337

Results by group540

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2506102 (M5)19.4020Geometric Coefficient of Variation 36.6Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2506102 (M5)11.3374Geometric Coefficient of Variation 26.7Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2506104 (M3)91.7692Geometric Coefficient of Variation 41.0Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2506104 (M3)50.1154Geometric Coefficient of Variation 28.3Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2531398 (M6)41.4666Geometric Coefficient of Variation 31.2Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2531398 (M6)21.0066Geometric Coefficient of Variation 23.5Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2531401 (M13)46.7001Geometric Coefficient of Variation 66.5Hour*nanogram per milliliter
Part 2: AUC (0-infinity) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2531401 (M13)31.9797Geometric Coefficient of Variation 40.9Hour*nanogram per milliliter
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK12788630.0463Standard Deviation 0.03971Percentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK12788630.0486Standard Deviation 0.03445Percentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2391220 (M2)0.1919Standard Deviation 0.14164Percentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2391220 (M2)0.4176Standard Deviation 0.38893Percentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2487818 (M4)0.5756Standard Deviation 0.89564Percentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2487818 (M4)0.6763Standard Deviation 0.61031Percentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2506102 (M5)0.6147Standard Deviation 0.17403Percentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2506102 (M5)2.1559Standard Deviation 2.01781Percentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2506104 (M3)NAStandard Deviation NAPercentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2506104 (M3)NAStandard Deviation NAPercentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2531398 (M6)0.2598Standard Deviation 0.10004Percentage of AUCex
Part 1: Percentage of AUC (0-infinity) Obtained by Extrapolation (Percentage AUCex) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2531398 (M6)0.3689Standard Deviation 0.26189Percentage of AUCex

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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