Trial · NCT03277222
Intranasal Treatment of HIV-associated Neurocognitive Disorders
NCT03277222, Phase 2, Terminated, University of Calgary
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Intranasal Treatment of HIV-associated Neurocognitive Disorders. Trials, record NCT03277222. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03277222
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Intranasal Treatment of HIV-associated Neurocognitive Disorders
- NCT number
- NCT03277222
- Status
- Terminated
- Phases
- Phase 2
- Enrollment
- 4 participants, actual
- Lead sponsor
- University of Calgary
- Conditions
- HIV Associated Neurocognitive Disorder (HAND)
- Interventions
- IN insulin, Sterile Saline placebo
- First posted
- 2017-09-08
- Last updated
- 2020-06-11
Source ClinicalTrials.gov
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Global Neurocognitive Performance from Baseline | 18 weeks | Change in overall neurocognitive function as measured by the global z score. The global z score is one measurement calculated as the average of z scores from each domain tested. |
| Secondary | Change from Baseline in Neurocognitive Performance: Memory | 18 weeks | Change from baseline in the overall z score for the memory domain, calculated as the average of z scores from: Hopkins Verbal Learning Test, Logical Memory Test, and Brief Visual Memory Test (immediate and delayed recall). |
| Secondary | Change from Baseline in Neurocognitive Performance: Executive Function | 18 weeks | Change from baseline in the overall z score for the executive function domain, calculated as the average of z scores from: D-KEFS Trail-making Task (Letter-Switching) and Color-Word Interference (Stroop). |
| Secondary | Change from Baseline in Neurocognitive Performance: Attention | 18 weeks | Change from baseline in the overall z score for the attention domain, calculated as the average of z scores from: Symbol Digit Modalities Test, D-KEFS Trail-making Test (Number), and Color-Word Interference (Color and Word Reading). |
| Secondary | Change from Baseline in Neurocognitive Performance: Motor Function | 18 weeks | Change from baseline in the overall z score for the motor function domain, calculated as the average of z scores from: grooved pegboard completion times for dominant and non-dominant hands. |
| Secondary | Change from Baseline in Neurocognitive Performance: Language | 18 weeks | Change from baseline in the overall z score for the language domain, calculated as the average of z scores from: D-KEFS Letter and Category Verbal Fluency Tasks |
| Other | Change from baseline in HQoL questionnaire score | 18 weeks | Change from baseline in health-related quality of life (HQoL) questionnaire score |
| Other | Change from baseline in the PHQ-9 Questionnaire score | 18 weeks | Change in the Patient Health Questionnaire-9 (PHQ-9) depressive symptoms score. |
| Other | Change from Baseline in the Frailty Index Score - questionnaire and clinic assessment | 16 weeks | Change in the overall Frailty Index score measured from baseline to Week 8. |
| Other | Change from Baseline HAND inflammasome biomarker laboratory result profile | 16 weeks | Change in inflammasome biomarker laboratory result profile between baseline and week 16. |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers32
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests6
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Short Story Recall | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03277222
GET https://conductscience.org/api/trials/v1/NCT03277222/papers?page=2