Registered outcomes13

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 13 of 13

List	Outcome	Time frame	Description
Primary	Change in Global Neurocognitive Performance from Baseline	18 weeks	Change in overall neurocognitive function as measured by the global z score. The global z score is one measurement calculated as the average of z scores from each domain tested.
Secondary	Change from Baseline in Neurocognitive Performance: Memory	18 weeks	Change from baseline in the overall z score for the memory domain, calculated as the average of z scores from: Hopkins Verbal Learning Test, Logical Memory Test, and Brief Visual Memory Test (immediate and delayed recall).
Secondary	Change from Baseline in Neurocognitive Performance: Executive Function	18 weeks	Change from baseline in the overall z score for the executive function domain, calculated as the average of z scores from: D-KEFS Trail-making Task (Letter-Switching) and Color-Word Interference (Stroop).
Secondary	Change from Baseline in Neurocognitive Performance: Attention	18 weeks	Change from baseline in the overall z score for the attention domain, calculated as the average of z scores from: Symbol Digit Modalities Test, D-KEFS Trail-making Test (Number), and Color-Word Interference (Color and Word Reading).
Secondary	Change from Baseline in Neurocognitive Performance: Motor Function	18 weeks	Change from baseline in the overall z score for the motor function domain, calculated as the average of z scores from: grooved pegboard completion times for dominant and non-dominant hands.
Secondary	Change from Baseline in Neurocognitive Performance: Language	18 weeks	Change from baseline in the overall z score for the language domain, calculated as the average of z scores from: D-KEFS Letter and Category Verbal Fluency Tasks
Other	Change from baseline in HQoL questionnaire score	18 weeks	Change from baseline in health-related quality of life (HQoL) questionnaire score
Other	Change from baseline in the PHQ-9 Questionnaire score	18 weeks	Change in the Patient Health Questionnaire-9 (PHQ-9) depressive symptoms score.
Other	Change from Baseline in the Frailty Index Score - questionnaire and clinic assessment	16 weeks	Change in the overall Frailty Index score measured from baseline to Week 8.
Other	Change from Baseline HAND inflammasome biomarker laboratory result profile	16 weeks	Change in inflammasome biomarker laboratory result profile between baseline and week 16.
Other	Change from Baseline HAND metabolomics biomarker laboratory result profile	16 weeks	Change in metabolomics biomarker laboratory result profile between baseline and week 16.
Other	Change from Baseline plasma HIV-1 viral load laboratory result	16 weeks	Change in plasma HIV-1 viral load between baseline and week 16.
Other	Change from Baseline blood CD4 T-cell count laboratory result	16 weeks	Change in blood CD4 T-cell count between baseline and week 16.

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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