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Trial · NCT03681184

Results by group60

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Percent Change in 24-hour Urinary Oxalate Excretion Corrected for Body Surface Area (BSA) From Baseline to Month 6Placebo/Lumasiran-11.8Standard Error 3.8percent change
Percent Change in 24-hour Urinary Oxalate Excretion Corrected for Body Surface Area (BSA) From Baseline to Month 6Lumasiran/Lumasiran-65.4Standard Error 2.9percent change
Absolute Change in 24-hour Urinary Oxalate Corrected for BSA From Baseline to Month 6Placebo/Lumasiran-0.27Standard Error 0.08mmol/24hr/1.73m^2
Absolute Change in 24-hour Urinary Oxalate Corrected for BSA From Baseline to Month 6Lumasiran/Lumasiran-1.24Standard Error 0.06mmol/24hr/1.73m^2
Percent Change in 24-hour Urinary Oxalate:Creatinine Ratio From Baseline to Month 6Placebo/Lumasiran-10.8Standard Error 5.4percent change
Percent Change in 24-hour Urinary Oxalate:Creatinine Ratio From Baseline to Month 6Lumasiran/Lumasiran-62.5Standard Error 4.0percent change
Percentage of Participants With 24-hour Urinary Oxalate Level Corrected for BSA at or Below 1.5 x ULN at Month 6Placebo/Lumasiran0percentage of participants
Percentage of Participants With 24-hour Urinary Oxalate Level Corrected for BSA at or Below 1.5 x ULN at Month 6Lumasiran/Lumasiran84.0percentage of participants
Percentage of Participants With 24-hour Urinary Oxalate Level Corrected for BSA at or Below ULN at Month 6Placebo/Lumasiran0percentage of participants
Percentage of Participants With 24-hour Urinary Oxalate Level Corrected for BSA at or Below ULN at Month 6Lumasiran/Lumasiran52.0percentage of participants
Percentage Change in Plasma Oxalate From Baseline to Month 6Placebo/Lumasiran-0.3Standard Error 4.3percent change
Percentage Change in Plasma Oxalate From Baseline to Month 6Lumasiran/Lumasiran-39.8Standard Error 2.9percent change
Absolute Change in Plasma Oxalate From Baseline to Month 6Placebo/Lumasiran1.3Standard Error 1.1μmol/L
Absolute Change in Plasma Oxalate From Baseline to Month 6Lumasiran/Lumasiran-7.5Standard Error 0.8μmol/L
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Placebo/LumasiranWeek 2-5Standard Deviation 9mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Lumasiran/LumasiranWeek 2-4Standard Deviation 9mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Placebo/LumasiranMonth 1-6Standard Deviation 7mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Lumasiran/LumasiranMonth 1-2Standard Deviation 12mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Placebo/LumasiranMonth 2-5Standard Deviation 8mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Lumasiran/LumasiranMonth 2-2Standard Deviation 15mL/min/1.73m^2

Source ClinicalTrials.govtrials-2026-11-12-0.4.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNone stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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