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Trial · NCT03681184

Results by group60

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Placebo/LumasiranMonth 3-3Standard Deviation 6mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Lumasiran/LumasiranMonth 30Standard Deviation 11mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Placebo/LumasiranMonth 4-4Standard Deviation 8mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Lumasiran/LumasiranMonth 4-4Standard Deviation 10mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Placebo/LumasiranMonth 5-4Standard Deviation 7mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Lumasiran/LumasiranMonth 5-6Standard Deviation 13mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Placebo/LumasiranMonth 60Standard Deviation 6mL/min/1.73m^2
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to Week 2 and Months 1, 2, 3, 4, 5 and 6Lumasiran/LumasiranMonth 6-3Standard Deviation 11mL/min/1.73m^2
Absolute Change in 24-hour Urinary Oxalate Excretion Corrected for BSA From Baseline in the Extension PeriodPlacebo/LumasiranAt Month 54-0.951Standard Deviation 0.6148mmol/24hr/1.73m^2
Absolute Change in 24-hour Urinary Oxalate Excretion Corrected for BSA From Baseline in the Extension PeriodLumasiran/LumasiranAt Month 54-1.086Standard Deviation 0.7678mmol/24hr/1.73m^2
Absolute Change in 24-hour Urinary Oxalate Excretion Corrected for BSA From Baseline in the Extension PeriodLumasiran/LumasiranAt Month 60-1.129Standard Deviation 0.7581mmol/24hr/1.73m^2
Percentage Change in 24-hour Urinary Oxalate Excretion Corrected by BSA From Baseline in the Extension PeriodPlacebo/LumasiranAt Month 54-55.57Standard Deviation 11.903percent change
Percentage Change in 24-hour Urinary Oxalate Excretion Corrected by BSA From Baseline in the Extension PeriodLumasiran/LumasiranAt Month 54-53.87Standard Deviation 41.919percent change
Percentage Change in 24-hour Urinary Oxalate Excretion Corrected by BSA From Baseline in the Extension PeriodLumasiran/LumasiranAt Month 60-53.98Standard Deviation 28.476percent change
Percentage of Time That 24-hour Urinary Oxalate is at or Below 1.5 × ULN During Lumasiran TreatmentPlacebo/Lumasiran89.44Full Range 21.1 to 99.3percentage of time
Percentage of Time That 24-hour Urinary Oxalate is at or Below 1.5 × ULN During Lumasiran TreatmentLumasiran/Lumasiran89.23Full Range 1.7 to 98.6percentage of time
Absolute Change in 24-hour Urinary Oxalate:Creatinine Ratio From Baseline in the Extension PeriodPlacebo/LumasiranAt Month 54-0.145Standard Deviation 0.1242mmol/mmol
Absolute Change in 24-hour Urinary Oxalate:Creatinine Ratio From Baseline in the Extension PeriodLumasiran/LumasiranAt Month 54-0.127Standard Deviation 0.1063mmol/mmol
Absolute Change in 24-hour Urinary Oxalate:Creatinine Ratio From Baseline in the Extension PeriodLumasiran/LumasiranAt Month 60-0.138Standard Deviation 0.1162mmol/mmol
Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline in the Extension PeriodPlacebo/LumasiranAt Month 54-12.860Standard Deviation 9.5386mL/min/1.73m^2

Source ClinicalTrials.govtrials-2026-11-12-0.4.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNone stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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