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Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus
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Trial · NCT03701074

Outcomes23

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

1 to 20 of 23

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TypeOutcomeTime framePopulationUnitsMeasured as
PRIMARYDuctus Arteriosus Closure/Constriction Rate24-48 hours after the completion of study interventionNone were enrolled for the control armParticipantsCOUNT_OF_PARTICIPANTS
SECONDARYEchocardiographic Patent Ductus Arteriosus Parameters Before and After the Study Intervention24-48 hours after the completion of study intervention
SECONDARYVentilatory Settings Before and After the Study Intervention24-48 hours after the completion of study intervention
SECONDARYRate of Liver Injury24-48 hours after the completion of study intervention
SECONDARYRate of Renal Injury24-48 hours after the completion of study intervention
SECONDARYRate of Hematological Adverse Events24-48 hours after the completion of study intervention
SECONDARYTotal Number of Days of Mechanical Ventilationfrom randomization until discharge/40 weeks post menstrual age
SECONDARYTotal Number of Days of Need for Supplemental Oxygenfrom randomization until discharge/40 weeks post menstrual age
SECONDARYDuration of Noninvasive Ventilationfrom randomization until discharge/40 weeks post menstrual age
SECONDARYRate of Persistence of Ductus-needing Pharmacological Treatmentfrom randomization until discharge/40 weeks post menstrual age
SECONDARYRate of Surgical Ligation of PDAfrom randomization until discharge/40 weeks post menstrual age
SECONDARYRate of Bronchopulmonary Dysplasiaat 36 weeks post menstrual age
SECONDARYPercentage of Infants Requiring Home Oxygen Therapyat discharge/40 weeks post menstrual age
SECONDARYDeath Before Dischargeuntil discharge/40 weeks post menstrual age
SECONDARYTime to Achieve Full Enteral Feedingfrom birth until discharge/40 weeks post menstrual age
SECONDARYDays on Total Parenteral Nutritionfrom birth until discharge/40 weeks post menstrual age
SECONDARYRetinopathy of Prematurityfrom birth until discharge/40 weeks post menstrual age
SECONDARYRate of Spontaneous Intestinal Perforationfrom randomization until discharge/40 weeks post menstrual age
SECONDARYRate of Necrotizing Enterocolitisfrom randomization until discharge/40 weeks post menstrual age
SECONDARYRate of Gastrointestinal Hemorrhagefrom randomization until discharge/40 weeks post menstrual age

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

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Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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GET https://conductscience.org/api/trials/v1/NCT03701074/outcomes

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