Trial · NCT03774446
Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease
NCT03774446, Phase 2, Completed, Cedars-Sinai Medical Center
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease. Trials, record NCT03774446. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03774446
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease
- NCT number
- NCT03774446
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 5 participants, actual
- Lead sponsor
- Cedars-Sinai Medical Center
- Conditions
- Cushing Disease
- Interventions
- Seliciclib
- First posted
- 2018-12-13
- Last updated
- 2026-10-16
Source ClinicalTrials.gov
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of participants with a normalized 24-hour urinary free cortisol (UFC) at study completion | 4 weeks | |
| Primary | Number of participants with UFC above the upper limit of normal (ULN) but reduced by ≥50% from baseline at study completion | 4 weeks | |
| Secondary | Plasma adrenocorticotrophic hormone | Baseline and week 4 | |
| Secondary | Salivary cortisol | Baseline and week 4 | |
| Secondary | Serum cortisol | Baseline and week 4 | |
| Secondary | Glycated hemoglobin (HbA1c) | Baseline and week 4 | |
| Secondary | Fasting blood glucose | Baseline and week 4 | |
| Secondary | Weight and height to report body mass index (BMI) in kg/m^2 | Baseline and week 4 | |
| Secondary | Blood pressure | Baseline and week 4 | |
| Secondary | Change on visual field exam | Baseline and week 4 |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03774446
GET https://conductscience.org/api/trials/v1/NCT03774446/registered