Trial · NCT03864523
Registered outcomes56
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 20 of 56
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | 2 Minute Walk Test (2MWT) | 24 months | The score at this test corresponds to the distance traveled by the patient during 2 minutes, on a flat surface |
| Secondary | Timed Up and Go (TUG) test | 24 months | It consists in standing up, walking 3 meters, turning around, walk back to the chair and sitting back down, at regular pace |
| Secondary | Time to walk 25 Feet (TW25) | 24 months | In this test the patient should walk 7.62 meters (25 feet) as quickly, but safely, as possible without running |
| Secondary | 6 Minute Walk Test (6MWT) | 24 months | It measures the distance an individual is able to walk over a total of six minutes on a hard, flat surface |
| Secondary | Sensory disturbances: tactile | 24 months | For the evaluation the Total Neuropathy Score (TNS) will be used (0-4) |
| Secondary | Sensory disturbances: painful | 24 months | For the evaluation the Total Neuropathy Score (TNS) will be used (0-4) |
| Secondary | Sensory disturbances: vibratory | 24 months | For the evaluation the Total Neuropathy Score (TNS) will be used (0-4) |
| Secondary | Expanded disability status scale (EDSS) | 24 months | This scale measures motor function, ranging from 0 (normal neurological examination) to 10 (death) |
| Secondary | Dynamometer test (optional) | 24 months | It measures the muscle strength |
| Secondary | Ashworth scale | 24 months | The Modified Ashworth Scale measures spasticity in patients who have lesions of the CNS or neurological disorders. The modified Ashworth scale ranges from 0 (no increase in tone) to 4 (Affected part(s) rigid in flexion or extension) |
| Secondary | SF-Qualiveen | 24 months | It measures the impact of urinary disorders in patients with neurological conditions |
| Secondary | Revised Faecal Incontinence Scale (RFIS) | 24 months | The RFIS is a short, reliable and valid five item scale used to asses faecal incontinence and to monitor patient outcomes following treatment. Response options are framed as 5-point Likert-type scales, with 0 indicating no impact of faecal incontinence problems on health-related quality of life and 4 indicating a high adverse impact. The RFIS total score is calculated by adding a person's score for each question. Adding the score for each of the five questions results in a possible score range of 0-20 |
| Secondary | Conventional MRI | 24 months | FLAIR and T2 sequences may show subtle anomalies evaluated using the Loes scoring system. This MRI severity scale has been designed specifically for X-linked adrenoleukodystrophy and has been shown to correlate with severity of neurologic deficits and to be predictive of disease progression. Different brain regions are considered in the MRI severity score. Each area is scored as 0 if normal, 0.5 if unilateral involvement, and 1 if the lesion or atrophy is bilateral. The maximum severity score is 34; a score of 1 is considered abnormal. |
| Secondary | Diffusion tensor Imaging (DTI) | 24 months | Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) will be measured |
| Secondary | Brain MRI spectroscopy (MRS) | 24 months | NAA/creatine and choline/creatine ratios will be measured |
| Secondary | Nerve conduction studies: conduction velocity in the peroneal nerve | 24 months | m/s |
| Secondary | Nerve conduction studies: amplitude of the signal in the peroneal motor nerve | 24 months | (mV) |
| Secondary | Nerve conduction studies: conduction velocity in the sura sensitive nerve | 24 months | (m/s) |
| Secondary | Nerve conduction studies: amplitude of the signal in the sura sensitive nerve | 24 months | (μV) |
| Secondary | Motor Evoked Potentials (MEP): F wave | 24 months | (ms) in right and left upper limb and right and left lower limb |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/trials/v1/NCT03864523/registered