Trial · NCT04198428

Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0)

NCT04198428, Not applicable, Completed, HealthPartners Institute; results first posted 2025-10-02

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0). Trials, record NCT04198428. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04198428

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Clinical Decision Support for Opioid Use Disorders in Medical Settings (COMPUTE 2.0)
NCT number: NCT04198428
Status: Completed
Phases: Not applicable
Enrollment: 10,891 participants, actual
Lead sponsor: HealthPartners Institute
Conditions: Opioid-use Disorder
Interventions: Opioid Wizard
First posted: 2019-12-13
Last updated: 2025-10-02
Results first posted: 2025-10-02

Source ClinicalTrials.gov

Registered outcomes9

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Number of Patients With OUD Diagnosis	Index visit date through 30 days post-index, inclusive.	Patient has an ICD10 diagnosis code for OUD assigned at an encounter or added to the problem list
Primary	Number of Patients With Naloxone Rescue Kit Order	Index visit date through 30 days post-index, inclusive.	Patient has a medication order for a naloxone rescue kit
Primary	Number of Patients With a MOUD Order or Referral	Index visit date through 30 days post-index, inclusive.	Patient has a medication order for a MOUD or referral for addiction treatment
Primary	Days Covered by MOUD Prescription	Index visit date through 90 days post-index, inclusive, with 0 days assigned if there were no MOUD orders.	The sum of unique days covered by a MOUD order
Secondary	Emergency Department Visits Per Patient-year	pre: one year through one day prior to the index visit; post: index visit through one year post-index or date of death, whichever was first.
Secondary	Hospitalizations Per Patient-year	pre: one year through one day prior to the index visit; post: index visit through one year post-index or date of death, whichever was first.
Secondary	Healthcare Costs	pre: one year through one day prior to the index visit; post: index visit through one year post-index or date of death, whichever was first.	Healthcare costs for prescribed medications and clinical inpatient, emergency, and outpatient services incurred, as documented in insurance claims or clinical encounter data.
Secondary	All-cause Mortality Per 100 Patient-years.	index visit through one year post-index, inclusive
Secondary	Overdoses Per 100 Patient-years.	pre: one year through one day prior to the index visit; post: index visit through one year post-index or date of death, whichever was first.

Source ClinicalTrials.gov

Outcomes9

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Number of Patients With OUD Diagnosis	Index visit date through 30 days post-index, inclusive.	Patients previously undiagnosed with OUD but identified as high risk by the OUD-CDS	participants	NUMBER
PRIMARY	Number of Patients With Naloxone Rescue Kit Order	Index visit date through 30 days post-index, inclusive.		participants	NUMBER
PRIMARY	Number of Patients With a MOUD Order or Referral	Index visit date through 30 days post-index, inclusive.		participants	NUMBER
PRIMARY	Days Covered by MOUD Prescription	Index visit date through 90 days post-index, inclusive, with 0 days assigned if there were no MOUD orders.		days	MEDIAN
SECONDARY	Emergency Department Visits Per Patient-year	pre: one year through one day prior to the index visit; post: index visit through one year post-index or date of death, whichever was first.		events per patient-year	NUMBER
SECONDARY	Hospitalizations Per Patient-year	pre: one year through one day prior to the index visit; post: index visit through one year post-index or date of death, whichever was first.		events per patient-year	NUMBER
SECONDARY	Healthcare Costs	pre: one year through one day prior to the index visit; post: index visit through one year post-index or date of death, whichever was first.		dollars	MEAN
SECONDARY	All-cause Mortality Per 100 Patient-years.	index visit through one year post-index, inclusive		events per 100 patient-years	NUMBER
SECONDARY	Overdoses Per 100 Patient-years.	pre: one year through one day prior to the index visit; post: index visit through one year post-index or date of death, whichever was first.		events per 100 patient-years	NUMBER

Source ClinicalTrials.gov

Results by group24

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Number of Patients With OUD Diagnosis	Receives OUD-CDS		36		participants
Number of Patients With OUD Diagnosis	Does Not Receive the OUD-CDS		24		participants
Number of Patients With Naloxone Rescue Kit Order	Receives OUD-CDS		80		participants
Number of Patients With Naloxone Rescue Kit Order	Does Not Receive the OUD-CDS		40		participants
Number of Patients With a MOUD Order or Referral	Receives OUD-CDS		785		participants
Number of Patients With a MOUD Order or Referral	Does Not Receive the OUD-CDS		517		participants
Days Covered by MOUD Prescription	Receives OUD-CDS		84	Inter-Quartile Range 55 to 90	days
Days Covered by MOUD Prescription	Does Not Receive the OUD-CDS		83	Inter-Quartile Range 55 to 90	days
Emergency Department Visits Per Patient-year	Receives OUD-CDS	pre-index	1.30	95% Confidence Interval 1.11 to 1.52	events per patient-year
Emergency Department Visits Per Patient-year	Does Not Receive the OUD-CDS	pre-index	1.37	95% Confidence Interval 1.12 to 1.68	events per patient-year

1 to 10 of 24Source ClinicalTrials.gov

See all 24 results by group

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants	Units counted
Overall Study	STARTED	Receives OUD-CDS	5,688	46
Overall Study	STARTED	Does Not Receive the OUD-CDS	5,509	46
Overall Study	COMPLETED	Receives OUD-CDS	5,538	46
Overall Study	COMPLETED	Does Not Receive the OUD-CDS	5,353	46
Overall Study	NOT COMPLETED	Receives OUD-CDS	150	0
Overall Study	NOT COMPLETED	Does Not Receive the OUD-CDS	156	0

Source ClinicalTrials.gov

Adverse events12

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Overdoses, pre-index	Injury, poisoning and procedural complications	Receives OUD-CDS	204	5,688	277
other	Overdoses, pre-index	Injury, poisoning and procedural complications	Does Not Receive the OUD-CDS	228	5,509	326
other	Overdoses, post-index	Injury, poisoning and procedural complications	Receives OUD-CDS	213	5,688	326
other	Overdoses, post-index	Injury, poisoning and procedural complications	Does Not Receive the OUD-CDS	225	5,509	342
serious	Emergency Visits, pre-index	General disorders	Receives OUD-CDS	2,591	5,688	7,519
serious	Emergency Visits, pre-index	General disorders	Does Not Receive the OUD-CDS	2,578	5,509	7,723
serious	Emergency Visits, post-index	General disorders	Receives OUD-CDS	2,643	5,688	9,560
serious	Emergency Visits, post-index	General disorders	Does Not Receive the OUD-CDS	2,737	5,509	10,443
serious	Hospitalizations, pre-index	General disorders	Receives OUD-CDS	1,198	5,688	2,260
serious	Hospitalizations, pre-index	General disorders	Does Not Receive the OUD-CDS	1,221	5,509	2,290

1 to 10 of 12Source ClinicalTrials.gov

See all 12 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Receives OUD-CDS	270	5,688
Total, all-cause mortality	Does Not Receive the OUD-CDS	268	5,509
Total, other adverse events	Receives OUD-CDS	375	5,688
Total, other adverse events	Does Not Receive the OUD-CDS	413	5,509
Total, serious adverse events	Receives OUD-CDS	3,740	5,688
Total, serious adverse events	Does Not Receive the OUD-CDS	3,752	5,509

Source ClinicalTrials.gov

Papers3

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
38756745	DERIVED	PubMed
39773800	DERIVED	PubMed
40658392	DERIVED	PubMed

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
UG1DA040316	NorthStar Node of the NIDA Clinical Trials Network	BART, GAVIN	HENNEPIN HEALTHCARE RESEARCH INSTITUTE	NATIONAL INSTITUTE ON DRUG ABUSE	2015 to 2025

Source NIH RePORTER

Trial comparisons5

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Receives OUD-CDS vs Does Not Receive the OUD-CDS: Number of Patients With a MOUD Order or Referral	Trial comparisons
Receives OUD-CDS vs Does Not Receive the OUD-CDS: Number of Patients With OUD Diagnosis	Trial comparisons
Receives OUD-CDS vs Does Not Receive the OUD-CDS: deaths from any cause	Trial comparisons
Receives OUD-CDS vs Does Not Receive the OUD-CDS: Number of Patients With Naloxone Rescue Kit Order	Trial comparisons
Receives OUD-CDS vs Does Not Receive the OUD-CDS: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT04198428

GET https://conductscience.org/api/trials/v1/NCT04198428/results?page=2

API reference For AI assistants