Trial · NCT04383262
Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme Reduction
NCT04383262, Phase 2, Recruiting, Medical College of Wisconsin
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme Reduction. Trials, record NCT04383262. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04383262
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme Reduction
- NCT number
- NCT04383262
- Status
- Recruiting
- Phases
- Phase 2
- Enrollment
- 104 participants, estimated
- Lead sponsor
- Medical College of Wisconsin
- Conditions
- Laryngopharyngeal Reflux
- Interventions
- Fosamprenavir Calcium, Placebo
- First posted
- 2020-05-12
- Last updated
- 2026-09-10
Source ClinicalTrials.gov
Registered outcomes24
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Reflux Symptom Index (RSI) | Baseline to 12-week post-treatment. | The absolute change from baseline (i.e., Pretreatment) in symptom severity as indicated by RSI Score over time, with the primary treatment comparison at Week 12 (End of Treatment Visit) |
| Primary | Change in Daily Symptom Reflux Diary (DRSD) | Baseline to 12-week post-treatment. | The absolute change from baseline (i.e., Pretreatment) in symptom severity as indicated by Weekly Total DRSD Score (WTDS) over time, with the primary treatment comparison at Week 12 (End of Treatment Visit) |
| Other | Change in Reflux Finding (RFS) | Baseline to 12-week post-treatment. | The absolute change from baseline in endoscopic signs severity as indicated by Reflux Finding Score (RFS) over time, with the primary treatment comparison at Week 12 |
| Other | Change in Reflux Symptom Scale (RSS). | Baseline to 12-week post-treatment. | The absolute change from baseline in symptom severity as indicated by Reflux Symptom Score (RSS) over time, with the primary treatment comparison at Week 12 |
| Other | Change in Reflux Sign Assessment (RSA) | Baseline to 12-week post-treatment. | The absolute change from baseline in endoscopic signs severity as indicated by Reflux Sign Assessment (RSA) score over time, with the primary treatment comparison at Week 12 |
| Other | Change in Voice Handicap Index 10 (VHI-10) | Baseline to 12-week post-treatment. | The absolute change from baseline in symptom severity as indicated by Voice Handicap Index-10 (VHI-10) score over time, with the primary treatment comparison at Week 12 |
| Other | Change in symptom-free days | Baseline to week 12 | The absolute change from baseline in weekly overall reflux symptom-free days as indicated by Weekly Symptom-Free Days (WSFD; i.e. the total number of symptom-free days per week, with symptom-free defined as "Did not have" response for all items on the DRSD), over time, with the primary exploratory treatment comparison at Week 12 |
| Other | Change in "throat-clearing" | Baseline to 12-week post-treatment | The absolute change from baseline in weekly "throat-clearing" symptom-free days (i.e. the total number of days per week that the patient responded "Did not have" for "throat-clearing" item on the DRSD), over time, with the primary exploratory treatment comparison at Week 12 |
| Other | Change in "sensation of something stuck in the throat" | Baseline to 12-week post-treatment | The absolute change from baseline in weekly "sensation of something stuck in the throat" symptom-free days (i.e. the total number of days per week that the patient responded "Did not have" for "sensation of something stuck in the throat" item on the DRSD), over time, with the primary exploratory treatment comparison at Week 12 |
| Other | Change in "excess mucus in the throat" | Baseline to 12-week post-treatment | The absolute change from baseline in weekly "excess mucus in the throat" symptom-free days (i.e. the total number of days per week that the patient responded "Did not have" for "excess mucus in the throat" item on the DRSD), over time, with the primary exploratory treatment comparison at Week 12 |
1 to 10 of 24Source ClinicalTrials.gov
See all 24 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04383262
GET https://conductscience.org/api/trials/v1/NCT04383262/registered?page=2