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A Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Participants With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis (CB)
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Trial · NCT04441788

Results by group45

Each measurement the trial posted, group by group, in the words and numbers it posted.

1 to 20 of 45

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OutcomeGroupCategoryValueSpreadUnits
Change From Baseline to the Primary Time Point in Forced Expiratory Volume in 1 Second (FEV1) Compared to PlaceboPlacebo0.0642Standard Deviation 0.2506liters
Change From Baseline to the Primary Time Point in Forced Expiratory Volume in 1 Second (FEV1) Compared to PlaceboION-827359 37.5 mg-0.0240Standard Deviation 0.3581liters
Change From Baseline to the Primary Time Point in Forced Expiratory Volume in 1 Second (FEV1) Compared to PlaceboION-827359 75 mg0.1336Standard Deviation 0.1087liters
Change From Baseline in the Exacerbations of Chronic Pulmonary Disease Tool (EXACT) Respiratory Symptoms (E-RS) Daily Symptom Diary Total Score to the Primary Time PointPlacebo-1.08Standard Deviation 1.171score on a scale
Change From Baseline in the Exacerbations of Chronic Pulmonary Disease Tool (EXACT) Respiratory Symptoms (E-RS) Daily Symptom Diary Total Score to the Primary Time PointION-827359 37.5 mg-1.41Standard Deviation 2.486score on a scale
Change From Baseline in the Exacerbations of Chronic Pulmonary Disease Tool (EXACT) Respiratory Symptoms (E-RS) Daily Symptom Diary Total Score to the Primary Time PointION-827359 75 mg-1.99Standard Deviation 4.217score on a scale
Change From Baseline in the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) to the Week 14 Time PointPlacebo-2.6Standard Deviation 2.51score on a scale
Change From Baseline in the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) to the Week 14 Time PointION-827359 37.5 mg-0.6Standard Deviation 3.78score on a scale
Change From Baseline in the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT) to the Week 14 Time PointION-827359 75 mg0.0Standard Deviation 1.73score on a scale
Change From Baseline in St. George's Respiratory Questionnaire - COPD Specific (SGRQ-C) Total Score to the Week 14 Time PointPlacebo-15.93Standard Deviation 19.515score on a scale
Change From Baseline in St. George's Respiratory Questionnaire - COPD Specific (SGRQ-C) Total Score to the Week 14 Time PointION-827359 37.5 mg-1.74Standard Deviation 3.839score on a scale
Change From Baseline in St. George's Respiratory Questionnaire - COPD Specific (SGRQ-C) Total Score to the Week 14 Time PointION-827359 75 mg-0.76Standard Deviation 2.350score on a scale
Change From Baseline in Post-Bronchodilator FEV1Placebo0.0663Standard Deviation 0.0685liters
Change From Baseline in Post-Bronchodilator FEV1ION-827359 37.5 mg0.0320Standard Deviation 0.2379liters
Change From Baseline in Post-Bronchodilator FEV1ION-827359 75 mg0.1180Standard Deviation 0.1006liters
Cmax: Maximum Observed Plasma Concentration for ION-827359ION-827359 37.5 mgDay 185.6Geometric Coefficient of Variation 198nanogram per milliliter (ng/mL)
Cmax: Maximum Observed Plasma Concentration for ION-827359ION-827359 75 mgDay 1203Geometric Coefficient of Variation 52.6nanogram per milliliter (ng/mL)
Cmax: Maximum Observed Plasma Concentration for ION-827359ION-827359 37.5 mgDay 8553.5Geometric Coefficient of Variation NAnanogram per milliliter (ng/mL)
Cmax: Maximum Observed Plasma Concentration for ION-827359ION-827359 75 mgDay 85195Geometric Coefficient of Variation 124nanogram per milliliter (ng/mL)
Tmax: Time to Reach the Maximum Plasma Concentration for ION-827359ION-827359 37.5 mgDay 11.54Full Range 0.567 to 2.05hours

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

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Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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