Trial · NCT04591678
Adults With SMA Treated With Nusinersen
NCT04591678, Completed, Ohio State University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Adults With SMA Treated With Nusinersen. Trials, record NCT04591678. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04591678
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Adults With SMA Treated With Nusinersen
- NCT number
- NCT04591678
- Status
- Completed
- Enrollment
- 15 participants, actual
- Lead sponsor
- Ohio State University
- Conditions
- Spinal Muscular Atrophy
- Interventions
- nusinersen
- First posted
- 2020-10-19
- Last updated
- 2021-09-22
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Muscle strength | 22 months | To evaluate the effect of nusinersen treatment on muscle strength in ambulatory SMA adults |
| Secondary | Change in Six Minute Walk Test | 22 months | 6 Minute Walk Test (6WMT) |
| Secondary | Change in Hammersmith Functional Motor Scale Expanded | 22 months | Hammersmith Functional Motor Scale Expanded (HFMSE) |
| Secondary | Change in SMA Functional Rating Scale | 22 months | modified SMA Functional Rating Scale(SMA-FRS) |
| Secondary | Change in Forced Vital Capacity | 22 months | Forced Vital Capacity (FVC) |
| Secondary | Change in Negative Inspiratory Force | 22 months | Negative Inspiratory Force (NIF) |
| Secondary | Change in lean muscle mass | 22 months | Muscle mass measured using Dual-Energy X-Ray Absorptiometry (DXA) |
| Secondary | Change in Quality of Life | 22 months | Quality of life will be measured using 36-Item Short Form Survey (SF-36) |
| Secondary | Change in Ulnar and Peroneal muscle measures | 22 months | Compound Muscle Action Potential Amplitude (CMAP) will be recorded |
| Secondary | Change in Motor Unit Number Estimation (MUNE) | 22 months | Ulnar nerve (Recording at the Abductor Digiti Minimi muscle) MUNE scores will be recorded |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04591678
GET https://conductscience.org/api/trials/v1/NCT04591678/registered