Trial · NCT04658654
Cognitive Effects of Roflumilast in (a)MCI and Mild Dementia Patients
NCT04658654, Phase 2, Unknown, Maastricht University Medical Center
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Cognitive Effects of Roflumilast in (a)MCI and Mild Dementia Patients. Trials, record NCT04658654. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04658654
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Cognitive Effects of Roflumilast in (a)MCI and Mild Dementia Patients
- NCT number
- NCT04658654
- Status
- Unknown
- Phases
- Phase 2
- Enrollment
- 81 participants, estimated
- Lead sponsor
- Maastricht University Medical Center
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Amnestic Mild Cognitive Disorder
- Interventions
- Roflumilast, Placebo oral tablet
- First posted
- 2020-12-08
- Last updated
- 2022-04-21
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Verbal Learning Test (VLT) (15 words) | Change from baseline to 24 weeks of chronic intake | |
| Secondary | Alzheimer's disease Assessment Scale- Cognitive Sub-scale (ADAS-Cog scale) | Change from baseline to 24 weeks of chronic intake | |
| Secondary | Mini Mental State Examination (MMSE) | Change from baseline to 24 weeks of chronic intake | |
| Secondary | Pattern Separation Task | Change from baseline to 24 weeks of chronic intake | |
| Secondary | Trail-Making Test (TMT) | Change from baseline to 24 weeks of chronic intake | |
| Secondary | Letter Digit Substitution Test (LDST) | Change from baseline to 24 weeks of chronic intake | |
| Secondary | Hospital Anxiety and Depression Scale (HADS) | Change from baseline to 24 weeks of chronic intake | |
| Secondary | Alzheimer's disease co-operative study activities of daily living (ADCS-ADL) scale | Change from baseline to 24 weeks of chronic intake | |
| Secondary | Neuropsychiatric Inventory (NPI) | Change from baseline to 24 weeks of chronic intake | |
| Secondary | QoL-AD | Change from baseline to 24 weeks of chronic intake |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 38438923 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Verbal Learning | Primary outcome | ConductCognition |
| Mnemonic Similarity Task | Secondary outcome | ConductCognition |
| Picture Naming Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04658654
GET https://conductscience.org/api/trials/v1/NCT04658654/registered