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Trial · NCT04770753

Results by group92

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Double-Blind Period: Percentage of Participants Who Achieved Hemoglobin (Hb) Response From Week 12 Through Week 24 Compared With BaselineMitapivat42.3Percentage of participants
Double-Blind Period: Percentage of Participants Who Achieved Hemoglobin (Hb) Response From Week 12 Through Week 24 Compared With BaselinePlacebo1.6Percentage of participants
Double-Blind Period: Change From Baseline in Average Functional Assessment of Chronic Illness Therapy (FACIT) -Fatigue Subscale Score From Week 12 Through Week 24Mitapivat4.85Standard Error 0.732score on a scale
Double-Blind Period: Change From Baseline in Average Functional Assessment of Chronic Illness Therapy (FACIT) -Fatigue Subscale Score From Week 12 Through Week 24Placebo1.46Standard Error 0.955score on a scale
Double-Blind Period: Change From Baseline in Average Hb Concentration From Week 12 Through Week 24Mitapivat8.57Standard Error 0.666Gram per Liter (g/L)
Double-Blind Period: Change From Baseline in Average Hb Concentration From Week 12 Through Week 24Placebo-1.06Standard Error 0.867Gram per Liter (g/L)
Double-Blind Period: Percentage of Participants Who Achieved Hb 1.5+ Response From Week 12 Through Week 24 Compared With BaselineMitapivat24.6Percentage of participants
Double-Blind Period: Percentage of Participants Who Achieved Hb 1.5+ Response From Week 12 Through Week 24 Compared With BaselinePlacebo0Percentage of participants
Double-Blind Period: Change From Baseline in Indirect Bilirubin at Week 24Mitapivat-10.65Standard Error 1.047Micromole per Liter (umol/L)
Double-Blind Period: Change From Baseline in Indirect Bilirubin at Week 24Placebo-0.03Standard Error 1.403Micromole per Liter (umol/L)
Double-Blind Period: Change From Baseline in Lactate Dehydrogenase (LDH) at Week 24Mitapivat-30.07Standard Error 7.131Units per Liter (U/L)
Double-Blind Period: Change From Baseline in Lactate Dehydrogenase (LDH) at Week 24Placebo-5.79Standard Error 9.440Units per Liter (U/L)
Double-Blind Period: Change From Baseline in Haptoglobin at Week 24Mitapivat-0.002Standard Error 0.0145Gram per Liter (g/L)
Double-Blind Period: Change From Baseline in Haptoglobin at Week 24Placebo0.017Standard Error 0.0199Gram per Liter (g/L)
Double-Blind Period: Change From Baseline in Reticulocytes at Week 24Mitapivat-32.11Standard Error 10.60010^9 cells per liter (10^9 cells/L)
Double-Blind Period: Change From Baseline in Reticulocytes at Week 24Placebo-14.74Standard Error 14.93210^9 cells per liter (10^9 cells/L)
Double-Blind Period: Change From Baseline in Erythropoietin at Week 24Mitapivat19.21Standard Error 37.773International units per Liter (IU/L)
Double-Blind Period: Change From Baseline in Erythropoietin at Week 24Placebo115.71Standard Error 49.413International units per Liter (IU/L)
Double-Blind Period: Percentage of Participants Who Achieved Patient Global Impression of Severity (PGIS)- Fatigue Response at Weeks 12, 16, 20, and 24MitapivatAt Week 1265.4percentage of participants
Double-Blind Period: Percentage of Participants Who Achieved Patient Global Impression of Severity (PGIS)- Fatigue Response at Weeks 12, 16, 20, and 24PlaceboAt Week 1246.9percentage of participants

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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