Trial · NCT05437575
Prehospital Analgesia INtervention Trial (PAIN)
NCT05437575, Phase 3, Recruiting, Jason Sperry
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Prehospital Analgesia INtervention Trial (PAIN). Trials, record NCT05437575. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05437575
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Prehospital Analgesia INtervention Trial (PAIN)
- NCT number
- NCT05437575
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 994 participants, estimated
- Lead sponsor
- Jason Sperry
- Conditions
- Traumatic Injury
- Interventions
- Ketamine Hydrochloride, Fentanyl Citrate
- First posted
- 2022-06-29
- Last updated
- 2026-03-09
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | 24-hour mortality | trauma bay arrival through 24 hours | All cause mortality within 24 hours from time of trauma bay arrival |
| Secondary | Hypoxia | from initial administration of PAIN prehospital analgesia through hospital arrival | incidence of hypoxia in the prehospital environment |
| Secondary | Hypotension | from initial administration of PAIN study prehospital analgesia through hospital arrival | incidence of hypotension in the prehospital environment |
| Secondary | Need for airway management | from initial administration of PAIN study prehospital analgesia through hospital arrival | need for airway management in the prehospital environment |
| Secondary | Prehospital pain assessment following analgesia | from initial administration of PAIN study prehospital analgesia through hospital arrival | prehospital pain assessment using Numeric Rating Scale (NRS)/Critical Care Pain Observational Tool (CPOT) scores. For Numeric Rating Scale, the patient rates their pain on a scale of 0 to 10 where 0 is no pain and 10 is the worst pain. The Critical Care Pain Observation Tool is used for patients who are intubated and cannot verbalize a pain score. Medical staff will observe the patient's behavior and score the patient's pain on a scale of 0 to 10, where 0 is no pain and 10 is the worst pain. |
| Secondary | Trauma bay arrival pain score | score assessed at time of arrival to trauma bay | pain assessment using Numeric Rating Scale (NRS)/Critical Care Pain Observation Tool (CPOT) score. For Numeric Rating Scale, patients rate their pain on a scale of 0 to 10 where 0 is no pain and 10 is the worst pain. The Critical Care Pain Observation Tool is used for patients who are intubated and cannot verbalize a pain score. A nurse will observe behavior and score the patient's pain on a scale of 0 to 10 where 0 is no pain and 10 is the worst pain. |
| Secondary | Number of analgesic doses necessary to reduce pain level to <5 NRS or CPOT less than 2 | from initial administration of PAIN study prehospital analgesia through hospital arrival | Number of analgesic doses necessary to reduce pain level to \<5 on Numeric Rating Scale or less than 2 on Critical Care Pain Observation Tool. For Numeric Rating Scale, the patient rates their pain on a scale of 0 to 10 where 0 is no pain and 10 is the worst pain. The Critical Care Pain Observation Tool is used for patients who are intubated and cannot verbalize a pain score. A nurse will observe behavior and score the patient's pain on a scale of 0 to 10 where 0 is no pain and 10 is the worst pain. |
| Secondary | 24 hour opioid use | from initial administration of PAIN study prehospital analgesia through 24 hours | total 24 hour opioid use |
| Secondary | Incidence of prehospital adverse events | from initial administration of PAIN study prehospital analgesia through hospital arrival | Incidence of adverse events of allergic reaction, emergence, laryngospasm, dysphoria, pruritus, and nausea |
| Secondary | Survival to hospital discharge | administration of PAIN study prehospital analgesia through hospital discharge or death up to 30 days | survival to hospital discharge |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05437575
GET https://conductscience.org/api/trials/v1/NCT05437575/registered