Trial · NCT05907707
Effects of Gamma-tACS on Memory and Sleep
NCT05907707, Not applicable, Completed, University of North Carolina, Chapel Hill; results first posted 2024-12-18
3 sourcestrials-2026-11-12-0.5.0
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ConductScience Library. Effects of Gamma-tACS on Memory and Sleep. Trials, record NCT05907707. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05907707
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effects of Gamma-tACS on Memory and Sleep
- NCT number
- NCT05907707
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 11 participants, actual
- Lead sponsor
- University of North Carolina, Chapel Hill
- Conditions
- Transcranial Alternating Current Stimulation, Aging, Cognitive Decline, Memory, Sleep
- Interventions
- Gamma transcranial alternating current stimulation, Control transcranial alternating current stimulation, EEG headband, Actigraphy wristband
- First posted
- 2023-06-18
- Last updated
- 2025-04-02
- Results first posted
- 2024-12-18
Source ClinicalTrials.gov
Registered outcomes19
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Percent of Participants Tolerating Cognitive Testing During tACS | Baseline (Day 1) | To establish acceptability of tACS combined with cognitive testing in healthy elderly participants and will be considered acceptable if at least \>/= 80% of participants tolerate the procedure. |
| Primary | Verbal Memory at Day 1 | Baseline (Day 1) | Participants will memorize 15 words ("Rey Auditory Verbal Learning Test") during gamma-tACS or control-tACS. They will be required to recall the words on the same day. The number of correctly remembered words will be recorded. |
| Primary | Verbal Memory at Day 2 | Follow-Up (Day 2) | Participants will memorize 15 words ("Rey Auditory Verbal Learning Test") during gamma-tACS or control-tACS. They will be required to recall the words on the day after. The number of correctly remembered words will be recorded. |
| Primary | Verbal Memory at Day 5 | Follow-Up (Day 5) | Participants will memorize 15 words ("Rey Auditory Verbal Learning Test") during gamma-tACS or control-tACS. They will be required to recall the words after 5 days. The number of correctly remembered words will be recorded. |
| Primary | Associative Verbal Memory at Day 1 | Baseline (Day 1) | Participants will memorize 8 word-pairs during gamma-tACS or control-tACS. They will be required to recall the pairs on the same day. The number of correctly remembered word pairs will be recorded. |
| Primary | Associative Verbal Memory at Day 2 | Follow-Up (Day 2) | Participants will memorize 8 word-pairs during gamma-tACS or control-tACS. They will be required to recall the pairs on the day after. The number of correctly remembered word pairs will be recorded. |
| Primary | Associative Verbal Memory at Day 5 | Follow-Up (Day 5) | Participants will memorize 8 word-pairs during gamma-tACS or control-tACS. They will be required to recall the pairs after 5 days. The number of correctly remembered word pairs will be recorded. |
| Primary | Percentage of Participants in Which it is Possible to Obtain at Least 4 Hours EEG Recording | Baseline (Day 1) | To establish feasibility of at-home use of a single-channel EEG device during sleep. This will be considered feasible if the device has been worn for at least 4 hours during the first night for \>/= 80% of participants. |
| Primary | Percentage of Participants Who Wear the EEG Device During All Three Nights for at Least 4 Hours | Baseline (Day 1) | To establish acceptability of at-home use of the single-channel EEG device during multiple nights. Acceptability will be considered as given if the device has been worn for at least 4 hours during each of the three nights in \>/=80% of participants. |
| Primary | Amount of Sleep Spindles in Sleep-EEG | Baseline (Day 1) | To investigate the effect of a single session of gamma-tACS (compared to control-tACS) on the number of sleep spindles occuring during the night after the intervention. Sleep spindles during the first two hours of sleep-EEG will be counted. A sleep spindle is defined as a train of sinusoidal waves with frequency 11-16 Hz and a duration of at least 0.5 seconds. |
1 to 10 of 19Source ClinicalTrials.gov
See all 19 registered outcomesOutcomes19
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Percent of Participants Tolerating Cognitive Testing During tACS | Baseline (Day 1) | One participant was not exposed to 40 Hz due to their time constraints. | percentage of participants | NUMBER |
| PRIMARY | Verbal Memory at Day 1 | Baseline (Day 1) | One participant was not exposed to 40 Hz due to their time constraints. | Number of words recalled | MEAN |
| PRIMARY | Verbal Memory at Day 2 | Follow-Up (Day 2) | One participant was not exposed to 40 Hz due to their time constraints. | Number of words recalled | MEAN |
| PRIMARY | Verbal Memory at Day 5 | Follow-Up (Day 5) | One participant was not exposed to 40 Hz due to their time constraints. | Number of words recalled | MEAN |
| PRIMARY | Associative Verbal Memory at Day 1 | Baseline (Day 1) | One participant was not exposed to 40 Hz due to their time constraints. | Number of word pairs recalled | MEAN |
| PRIMARY | Associative Verbal Memory at Day 2 | Follow-Up (Day 2) | One participant was not exposed to 40 Hz due to their time constraints. | Number of word pairs recalled | MEAN |
| PRIMARY | Associative Verbal Memory at Day 5 | Follow-Up (Day 5) | One participant was not exposed to 40 Hz due to their time constraints. | Number of word pairs recalled | MEAN |
| PRIMARY | Percentage of Participants in Which it is Possible to Obtain at Least 4 Hours EEG Recording | Baseline (Day 1) | One participant was not exposed to 40 Hz due to their time constraints. | percentage of participants | NUMBER |
| PRIMARY | Percentage of Participants Who Wear the EEG Device During All Three Nights for at Least 4 Hours | Baseline (Day 1) | One participant was not exposed to 40 Hz due to their time constraints. | percentage of participants | NUMBER |
| PRIMARY | Amount of Sleep Spindles in Sleep-EEG | Baseline (Day 1) | Data were not properly collected for some participants due to technical difficulties. | Number of sleep spindles | MEAN |
1 to 10 of 19Source ClinicalTrials.gov
See all 19 outcomesResults by group66
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Percent of Participants Tolerating Cognitive Testing During tACS | Gamma (40Hz) Stimulation | 100 | percentage of participants | ||
| Percent of Participants Tolerating Cognitive Testing During tACS | Active Control (21 Hz) Stimulation | 100 | percentage of participants | ||
| Verbal Memory at Day 1 | Gamma (40Hz) Stimulation | 7.7 | Standard Deviation 1.7 | Number of words recalled | |
| Verbal Memory at Day 1 | Active Control (21 Hz) Stimulation | 6.9 | Standard Deviation 2.4 | Number of words recalled | |
| Verbal Memory at Day 2 | Gamma (40Hz) Stimulation | 5.7 | Standard Deviation 1.9 | Number of words recalled | |
| Verbal Memory at Day 2 | Active Control (21 Hz) Stimulation | 5.5 | Standard Deviation 2.5 | Number of words recalled | |
| Verbal Memory at Day 5 | Gamma (40Hz) Stimulation | 4.1 | Standard Deviation 2.2 | Number of words recalled | |
| Verbal Memory at Day 5 | Active Control (21 Hz) Stimulation | 3.9 | Standard Deviation 2.3 | Number of words recalled | |
| Associative Verbal Memory at Day 1 | Gamma (40Hz) Stimulation | 6.1 | Standard Deviation 0.6 | Number of word pairs recalled | |
| Associative Verbal Memory at Day 1 | Active Control (21 Hz) Stimulation | 5.7 | Standard Deviation 1.6 | Number of word pairs recalled |
1 to 10 of 66Source ClinicalTrials.gov
See all 66 results by groupParticipant flow18
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| First Intervention | STARTED | First Gamma (40Hz) Stimulation, Then Active Control (21Hz) Stimulation | 5 | |
| First Intervention | STARTED | First Active Control (21 Hz) Stimulation, Then Gamma (40 Hz) Stimulation | 6 | |
| First Intervention | COMPLETED | First Gamma (40Hz) Stimulation, Then Active Control (21Hz) Stimulation | 5 | |
| First Intervention | COMPLETED | First Active Control (21 Hz) Stimulation, Then Gamma (40 Hz) Stimulation | 6 | |
| First Intervention | NOT COMPLETED | First Gamma (40Hz) Stimulation, Then Active Control (21Hz) Stimulation | 0 | |
| First Intervention | NOT COMPLETED | First Active Control (21 Hz) Stimulation, Then Gamma (40 Hz) Stimulation | 0 | |
| Washout (9 Days) | STARTED | First Gamma (40Hz) Stimulation, Then Active Control (21Hz) Stimulation | 5 | |
| Washout (9 Days) | STARTED | First Active Control (21 Hz) Stimulation, Then Gamma (40 Hz) Stimulation | 6 | |
| Washout (9 Days) | COMPLETED | First Gamma (40Hz) Stimulation, Then Active Control (21Hz) Stimulation | 5 | |
| Washout (9 Days) | COMPLETED | First Active Control (21 Hz) Stimulation, Then Gamma (40 Hz) Stimulation | 6 |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | First Gamma (40Hz) Stimulation | 0 | 10 |
| Total, all-cause mortality | First Active Control (21 Hz) Stimulation | 0 | 11 |
| Total, other adverse events | First Gamma (40Hz) Stimulation | 0 | 10 |
| Total, other adverse events | First Active Control (21 Hz) Stimulation | 0 | 11 |
| Total, serious adverse events | First Gamma (40Hz) Stimulation | 0 | 10 |
| Total, serious adverse events | First Active Control (21 Hz) Stimulation | 0 | 11 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| First Gamma (40Hz) Stimulation vs First Active Control (21 Hz) Stimulation: deaths from any cause | Trial comparisons |
| First Gamma (40Hz) Stimulation vs First Active Control (21 Hz) Stimulation: serious adverse events | Trial comparisons |
Tests5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Verbal Learning | Primary outcome | ConductCognition |
| Go/No-Go Task | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05907707
GET https://conductscience.org/api/trials/v1/NCT05907707/results?page=2