Trial · NCT05907707
Registered outcomes19
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 19 of 19
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Percent of Participants Tolerating Cognitive Testing During tACS | Baseline (Day 1) | To establish acceptability of tACS combined with cognitive testing in healthy elderly participants and will be considered acceptable if at least \>/= 80% of participants tolerate the procedure. |
| Primary | Verbal Memory at Day 1 | Baseline (Day 1) | Participants will memorize 15 words ("Rey Auditory Verbal Learning Test") during gamma-tACS or control-tACS. They will be required to recall the words on the same day. The number of correctly remembered words will be recorded. |
| Primary | Verbal Memory at Day 2 | Follow-Up (Day 2) | Participants will memorize 15 words ("Rey Auditory Verbal Learning Test") during gamma-tACS or control-tACS. They will be required to recall the words on the day after. The number of correctly remembered words will be recorded. |
| Primary | Verbal Memory at Day 5 | Follow-Up (Day 5) | Participants will memorize 15 words ("Rey Auditory Verbal Learning Test") during gamma-tACS or control-tACS. They will be required to recall the words after 5 days. The number of correctly remembered words will be recorded. |
| Primary | Associative Verbal Memory at Day 1 | Baseline (Day 1) | Participants will memorize 8 word-pairs during gamma-tACS or control-tACS. They will be required to recall the pairs on the same day. The number of correctly remembered word pairs will be recorded. |
| Primary | Associative Verbal Memory at Day 2 | Follow-Up (Day 2) | Participants will memorize 8 word-pairs during gamma-tACS or control-tACS. They will be required to recall the pairs on the day after. The number of correctly remembered word pairs will be recorded. |
| Primary | Associative Verbal Memory at Day 5 | Follow-Up (Day 5) | Participants will memorize 8 word-pairs during gamma-tACS or control-tACS. They will be required to recall the pairs after 5 days. The number of correctly remembered word pairs will be recorded. |
| Primary | Percentage of Participants in Which it is Possible to Obtain at Least 4 Hours EEG Recording | Baseline (Day 1) | To establish feasibility of at-home use of a single-channel EEG device during sleep. This will be considered feasible if the device has been worn for at least 4 hours during the first night for \>/= 80% of participants. |
| Primary | Percentage of Participants Who Wear the EEG Device During All Three Nights for at Least 4 Hours | Baseline (Day 1) | To establish acceptability of at-home use of the single-channel EEG device during multiple nights. Acceptability will be considered as given if the device has been worn for at least 4 hours during each of the three nights in \>/=80% of participants. |
| Primary | Amount of Sleep Spindles in Sleep-EEG | Baseline (Day 1) | To investigate the effect of a single session of gamma-tACS (compared to control-tACS) on the number of sleep spindles occuring during the night after the intervention. Sleep spindles during the first two hours of sleep-EEG will be counted. A sleep spindle is defined as a train of sinusoidal waves with frequency 11-16 Hz and a duration of at least 0.5 seconds. |
| Primary | Amount of Slow Wave Sleep in Sleep-EEG | Baseline (Day 1) | To investigate the effect of a single session of gamma-tACS (compared to control-tACS) on the amount of slow wave sleep (deep/delta sleep) occuring during the night after the intervention. The amount of slow wave sleep during the first two hours of sleep-EEG will be counted. |
| Secondary | Performance in Phonematic Fluency-Correct Words | Baseline (Day 1), Follow-Up (Day 2) | To investigate the effect of a single session of gamma-tACS (compared to control-tACS) on a phonematic fluency-task during 1 minute. The number of correct words will be calculated. |
| Secondary | Performance in Phonematic Fluency-Perseverations | Baseline (Day 1), Follow-Up (Day 2) | To investigate the effect of a single session of gamma-tACS (compared to control-tACS) on a phonematic fluency-task (i.e. production of words that start with a specific letter) during 1 minute. Number of correct words, number of perseverations and number of rule breaks will be calculated. |
| Secondary | Performance in Phonematic Fluency-Rule Breaks | Baseline (Day 1), Follow-Up (Day 2) | To investigate the effect of a single session of gamma-tACS (compared to control-tACS) on a phonematic fluency-task during 1 minute. Number of correct words, number of perseverations and number of rule breaks will be calculated. |
| Secondary | Executive Functioning (Time to Complete Stroop Test) | Baseline (Day 1), Follow-Up (Day 2) | To investigate the effect of a single session of gamma-tACS (compared to control-tACS) on the Stroop Color and Word Test during and on the day after the intervention. Time for test completion and errors will be calculated. Selective attention was evaluated with the Stroop Color Word Interference Test. In the interference portion of this test, the subject identifies the color of ink in which words ("red", "green", or "blue") are printed, requiring the subject to inhibit their natural tendency to read the word. A subject's score is the time taken to identify 50 stimulus items. The time taken to complete the maze is inversely proportional to the cognitive function. |
| Secondary | Executive Functioning (Trail Making Test) | Baseline (Day 1), Follow-Up (Day 2) | To investigate the effect of a single session of gamma-tACS (compared to control-tACS) on the Trail Making Test (TMT; connecting a set of numbers and numbers and letters as quickly as possible while maintaining accuracy) during and on the day after the intervention. The TMT (Part A and Part B) is a measure of visuomotor processing/sequencing speed. Participants must draw a line connecting numbers in ascending order as quickly as possible. Completion time in seconds is recorded (0-120, where lower scores represent better performance). Completion time of Part B is divided by completion time of Part A (Ratio B/A). |
| Secondary | Attentional Performance (TAP) | Baseline (Day 1), Follow-Up (Day 2) | To investigate the effect of a single session of gamma-tACS (compared to control-tACS) on subtests of the Test of Attentional Performance (TAP) during and on the day after the intervention. Percentile ranks for the following subtests will be calculated: Alertness (reaction time under two conditions), Go/NoGo (stimuli that require a selective reaction, that is, to react or not to react), Divided Attention (a visual and an auditory task must be processed in parallel), Visual Scanning (a matrix-like arrangement of 5 x 5 stimuli is used, the aim being to detect whether this arrangement includes a critical stimulus or not). |
| Other | Exploration of a Relationship (Correlation) Between the Amount of Sleep Spindles and Slow Wave Sleep With Recall | Baseline (Day 1), Follow-Up (Day 2) | A relationship is defined as a correlation (Pearson's) between memory recall performance (amount of words recalled) and sleep EEG features (especially spindles, slow waves), i.e., whether better memory recall is associated with more sleep spindles and more slow wave sleep in the night after stimulation. |
| Other | Exploration of a Relationship (Correlation) of Sleep-Wake-Schedule Changes and Type of Stimulation | Baseline (Day 1), Follow-Up (Day 2) | To see whether there is a correlation (Pearson's) between type of stimulation/wearing EEG and the motor activity pattern (measured by actigraphy wristband). |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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