Trial · NCT05987709
Study of Colorectal Cancer Screening Options
NCT05987709, Not applicable, Completed, Kaiser Permanente; results first posted 2025-12-16
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Study of Colorectal Cancer Screening Options. Trials, record NCT05987709. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT05987709
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Study of Colorectal Cancer Screening Options
- NCT number
- NCT05987709
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 2,004 participants, actual
- Lead sponsor
- Kaiser Permanente
- Conditions
- Colon Cancer
- Interventions
- GuardantSHIELD Blood Test
- First posted
- 2023-08-14
- Last updated
- 2025-12-16
- Results first posted
- 2025-12-16
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Assess Colorectal Cancer Screening Completion | Within 3 months of patient identification | Assess the percentage who received any CRC screening test (blood draw, FIT or FIT-DNA, or flexible sigmoidoscopy or colonoscopy) within 3 months of eligibility determination among eligible individuals in the blood test and usual care groups. |
| Secondary | Assess the Percentage of Participants Who Completed Follow-up Testing. | Within 6 months of abnormal FIT test | Assess the percentage of participants who completed follow-up colonoscopy within 6 months of their result among individuals with an abnormal non-invasive test result; comparing the blood test and usual care groups. |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Assess Colorectal Cancer Screening Completion | Within 3 months of patient identification | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Assess the Percentage of Participants Who Completed Follow-up Testing. | Within 6 months of abnormal FIT test | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Assess Colorectal Cancer Screening Completion | Guardant Shield Blood Test | 305 | Participants | ||
| Assess Colorectal Cancer Screening Completion | Standard of Care | 130 | Participants | ||
| Assess the Percentage of Participants Who Completed Follow-up Testing. | Guardant Shield Blood Test | 11 | Participants | ||
| Assess the Percentage of Participants Who Completed Follow-up Testing. | Standard of Care | 7 | Participants |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Guardant Shield Blood Test | 1,001 | |
| Overall Study | STARTED | Standard of Care | 1,003 | |
| Overall Study | COMPLETED | Guardant Shield Blood Test | 1,001 | |
| Overall Study | COMPLETED | Standard of Care | 1,003 | |
| Overall Study | NOT COMPLETED | Guardant Shield Blood Test | 0 | |
| Overall Study | NOT COMPLETED | Standard of Care | 0 |
Source ClinicalTrials.gov
Adverse events2
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Pain | Skin and subcutaneous tissue disorders | Guardant Shield Blood Test | 1 | 1,001 | 1 |
| other | Pain | Skin and subcutaneous tissue disorders | Standard of Care | 0 | 1,003 | 0 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Guardant Shield Blood Test | 0 | 1,001 |
| Total, all-cause mortality | Standard of Care | 0 | 1,003 |
| Total, other adverse events | Guardant Shield Blood Test | 1 | 1,001 |
| Total, other adverse events | Standard of Care | 0 | 1,003 |
| Total, serious adverse events | Guardant Shield Blood Test | 0 | 1,001 |
| Total, serious adverse events | Standard of Care | 0 | 1,003 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 38176899 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons4
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Guardant Shield Blood Test vs Standard of Care: Assess the Percentage of Participants Who Completed Follow-up Testing. | Trial comparisons |
| Guardant Shield Blood Test vs Standard of Care: Assess Colorectal Cancer Screening Completion | Trial comparisons |
| Guardant Shield Blood Test vs Standard of Care: deaths from any cause | Trial comparisons |
| Guardant Shield Blood Test vs Standard of Care: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT05987709
GET https://conductscience.org/api/trials/v1/NCT05987709/registered