Trial · NCT06027593
Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions
NCT06027593, Not applicable, Completed, Children's Hospital of Philadelphia; results first posted 2025-11-14
3 sourcestrials-2026-11-12-0.4.0
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ConductScience Library. Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions. Trials, record NCT06027593. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06027593
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Using Electronically Derived Automated Reports of Appropriate Antibiotic Use to Inform Stewardship Interventions
- NCT number
- NCT06027593
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 26,139 participants, actual
- Lead sponsor
- Children's Hospital of Philadelphia
- Conditions
- Community-acquired Pneumonia, Acute Otitis Media, Pharyngitis
- Interventions
- Quasi experimental intervention
- First posted
- 2023-09-07
- Last updated
- 2025-11-14
- Results first posted
- 2025-11-14
Source ClinicalTrials.gov
Registered outcomes28
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Guideline-concordant Antibiotic Use for Adults With Pharyngitis | Pre-intervention and post-intervention, up to 2 years | Count of participants with pharyngitis with guideline-concordant antibiotic use for all three metrics (decision to prescribe an antibiotic, antibiotic choice, and antibiotic duration). The count of participants with pharyngitis with guideline-concordant antibiotic use for all three metrics was divided by the total number of participants with pharyngitis to generate the percentage of participants receiving guideline-concordant antibiotic use for all three metrics. These proportions were compared for the group of participants in the pre intervention period (1 year) and the post intervention period (1 year). There were not individual participant level measures for this outcome. |
| Primary | Guideline-concordant Antibiotic Use for Children With Acute Otitis Media | Pre-intervention and post-intervention, up to 2 years | Count of participants with acute otitis media with guideline-concordant antibiotic use for all three metrics (decision to prescribe an antibiotic, antibiotic choice, and antibiotic duration). The count of participants with acute otitis media with guideline-concordant antibiotic use for all three metrics was divided by the total number of participants with pediatric acute otitis media who were prescribed antibiotics to generate the percentage of participants receiving guideline-concordant antibiotic use for all three metrics. These proportions were compared for the group of participants in the pre intervention period (1 year) and the post intervention period (1 year). There were not individual participant level measures for this outcome. |
| Primary | Guideline-concordant Antibiotic Use for Adults With Community-acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Count of participants with community-acquired pneumonia with guideline-concordant antibiotic use for all three metrics (decision to prescribe an antibiotic, antibiotic choice, and antibiotic duration). The count of participants with community-acquired pneumonia with guideline-concordant antibiotic use for all three metrics was divided by the total number of participants with community-acquired pneumonia to generate the percentage of participants receiving guideline-concordant antibiotic use for all three metrics. These proportions were compared for the group of participants in the pre intervention period (1 year) and the post intervention period (1 year). There were not individual participant level measures for this outcome. |
| Primary | Guideline-concordant Antibiotic Use for Children With Community-acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Count of participants with pediatric community-acquired pneumonia with guideline-concordant antibiotic use for all three metrics (decision to prescribe an antibiotic, antibiotic choice, and antibiotic duration). The count of participants with pediatric community-acquired pneumonia with guideline-concordant antibiotic use for all three metrics was divided by the total number of participants with pediatric community-acquired pneumonia to generate the percentage of participants receiving guideline-concordant antibiotic use for all three metrics. These proportions were compared for the group of participants in the pre intervention period (1 year) and the post intervention period (1 year). There were not individual participant level measures for this outcome. |
| Secondary | Guideline-concordant Antibiotic Choice for Adults Hospitalized With Community Acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Count of participants with community-acquired pneumonia with guideline-concordant antibiotic use for antibiotic choice. The count of participants with community-acquired pneumonia with guideline-concordant antibiotic use for this metric was divided by the total number of participants with community-acquired pneumonia to generate the percentage of participants receiving guideline-concordant antibiotic use for antibiotic choice. These proportions were compared for the group of participants in the pre intervention period (1 year) and the post intervention period (1 year). There were not individual participant level measures for this outcome. |
| Secondary | Guideline-concordant Antibiotic Duration for Adults Hospitalized With Community Acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Count of participants with community-acquired pneumonia with guideline-concordant antibiotic use for antibiotic duration. The count of participants with community-acquired pneumonia with guideline-concordant antibiotic use for this metric was divided by the total number of participants with community-acquired pneumonia to generate the percentage of participants receiving guideline-concordant antibiotic use for antibiotic duration. These proportions were compared for the group of participants in the pre intervention period (1 year) and the post intervention period (1 year). There were not individual participant level measures for this outcome. |
| Secondary | 30-day Community Acquired Pneumonia-related Outpatient Revisits (Emergency Department, Urgent Care, or Primary Care) in Adults | 30 days | Count of participants with community-acquired pneumonia with a return visit in the outpatient setting (emergency department, urgent care, or primary care) for community acquired pneumonia within 30 days of discharge following index hospitalization for adult community acquired pneumonia. The count of participants with community-acquired pneumonia with a return visit in the outpatient setting was divided by the total number of participants with community-acquired pneumonia to generate the percentage of participants with a return visit in the outpatient setting. |
| Secondary | 30-day Readmissions for Community Acquired Pneumonia in Adults | 30 days | Count of participants with a readmission for community-acquired pneumonia within 30 days of discharge following an index hospitalization for community-acquired pneumonia. The count of participants with a readmission for community-acquired pneumonia was divided by the total number of participants with community-acquired pneumonia to generate the percentage of participants with readmissions within 30 days of discharge following an index hospitalization for community-acquired pneumonia. |
| Secondary | Guideline-concordant Antibiotic Choice for Pediatric Community Acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Count of participants with pediatric community-acquired pneumonia with guideline-concordant antibiotic use for antibiotic choice. The count of participants with pediatric community-acquired pneumonia with guideline-concordant antibiotic use for this metric was divided by the total number of participants with pediatric community-acquired pneumonia to generate the percentage of participants receiving guideline-concordant antibiotic use for antibiotic choice. These proportions were compared for the group of participants in the pre intervention period (1 year) and the post intervention period (1 year). There were not individual participant level measures for this outcome. |
| Secondary | Guideline-concordant Antibiotic Duration for Pediatric Community Acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Count of participants with pediatric community-acquired pneumonia with guideline-concordant antibiotic use for antibiotic duration. The count of participants with pediatric community-acquired pneumonia with guideline-concordant antibiotic use for this metric was divided by the total number of participants with pediatric community-acquired pneumonia to generate the percentage of participants receiving guideline-concordant antibiotic use for antibiotic duration. These proportions were compared for the group of participants in the pre intervention period (1 year) and the post intervention period (1 year). There were not individual participant level measures for this outcome. |
1 to 10 of 28Source ClinicalTrials.gov
See all 28 registered outcomesOutcomes28
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Guideline-concordant Antibiotic Use for Adults With Pharyngitis | Pre-intervention and post-intervention, up to 2 years | Data for adults with pharyngitis only | Participants | COUNT_OF_PARTICIPANTS |
| PRIMARY | Guideline-concordant Antibiotic Use for Children With Acute Otitis Media | Pre-intervention and post-intervention, up to 2 years | Note: this metric of guideline-concordant antibiotic use was measured using a denominator of those who were prescribed antibiotics (pre-intervention: 9,020 participants; post-intervention: 7,778 participants). The overall number of participants with acute otitis media (pre-intervention: 10,167 participants; post-intervention: 8,741 participants) was NOT used as the denominator for this reason. | Participants | COUNT_OF_PARTICIPANTS |
| PRIMARY | Guideline-concordant Antibiotic Use for Adults With Community-acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Data for adults with community-acquired pneumonia only | Participants | COUNT_OF_PARTICIPANTS |
| PRIMARY | Guideline-concordant Antibiotic Use for Children With Community-acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Data for children with community-acquired pneumonia only | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Guideline-concordant Antibiotic Choice for Adults Hospitalized With Community Acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Data for adults hospitalized with community acquired pneumonia only | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Guideline-concordant Antibiotic Duration for Adults Hospitalized With Community Acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Data for adults hospitalized with community acquired pneumonia only | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | 30-day Community Acquired Pneumonia-related Outpatient Revisits (Emergency Department, Urgent Care, or Primary Care) in Adults | 30 days | Data for adults with community acquired pneumonia only | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | 30-day Readmissions for Community Acquired Pneumonia in Adults | 30 days | Data for adults with community acquired pneumonia only | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Guideline-concordant Antibiotic Choice for Pediatric Community Acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Data for pediatric community acquired pneumonia only | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Guideline-concordant Antibiotic Duration for Pediatric Community Acquired Pneumonia | Pre-intervention and post-intervention, up to 2 years | Data for pediatric community acquired pneumonia only | Participants | COUNT_OF_PARTICIPANTS |
1 to 10 of 28Source ClinicalTrials.gov
See all 28 outcomesResults by group52
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Guideline-concordant Antibiotic Use for Adults With Pharyngitis | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 1458 | Participants | ||
| Guideline-concordant Antibiotic Use for Adults With Pharyngitis | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 2477 | Participants | ||
| Guideline-concordant Antibiotic Use for Children With Acute Otitis Media | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 6154 | Participants | ||
| Guideline-concordant Antibiotic Use for Children With Acute Otitis Media | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 6287 | Participants | ||
| Guideline-concordant Antibiotic Use for Adults With Community-acquired Pneumonia | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 204 | Participants | ||
| Guideline-concordant Antibiotic Use for Adults With Community-acquired Pneumonia | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 242 | Participants | ||
| Guideline-concordant Antibiotic Use for Children With Community-acquired Pneumonia | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 213 | Participants | ||
| Guideline-concordant Antibiotic Use for Children With Community-acquired Pneumonia | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 308 | Participants | ||
| Guideline-concordant Antibiotic Choice for Adults Hospitalized With Community Acquired Pneumonia | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 268 | Participants | ||
| Guideline-concordant Antibiotic Choice for Adults Hospitalized With Community Acquired Pneumonia | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 302 | Participants |
1 to 10 of 52Source ClinicalTrials.gov
See all 52 results by groupParticipant flow14
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 12,917 | |
| Overall Study | STARTED | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 13,222 | |
| Overall Study | Adult Inpatients With Community Acquired Pneumonia | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 305 | |
| Overall Study | Adult Inpatients With Community Acquired Pneumonia | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 330 | |
| Overall Study | Pediatric Inpatients With Community Acquired Pneumonia | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 413 | |
| Overall Study | Pediatric Inpatients With Community Acquired Pneumonia | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 387 | |
| Overall Study | Adult Outpatients With Pharyngitis | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 2,032 | |
| Overall Study | Adult Outpatients With Pharyngitis | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 3,764 | |
| Overall Study | Pediatric Outpatients With Acute Otitis Media | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 10,167 | |
| Overall Study | Pediatric Outpatients With Acute Otitis Media | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 8,741 |
1 to 10 of 14Source ClinicalTrials.gov
See all 14 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 0 | 0 |
| Total, all-cause mortality | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 0 | 0 |
| Total, other adverse events | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 0 | 0 |
| Total, other adverse events | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 0 | 0 |
| Total, serious adverse events | Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 0 | 0 |
| Total, serious adverse events | Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period | 0 | 0 |
Source ClinicalTrials.gov
Papers19
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons24
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: Guideline-concordant Decision to Prescribe Antibiotics for Adult Pharyngitis | Trial comparisons |
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: 30-day Community Acquired Pneumonia-related Outpatient Revisits (Emergency Department, Urgent Care, or Primary Care) in Adults | Trial comparisons |
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: 30-day Readmissions for Community Acquired Pneumonia in Adults | Trial comparisons |
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: Guideline-concordant Antibiotic Choice Adult Pharyngitis | Trial comparisons |
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: Guideline-concordant Antibiotic Choice for Pediatric Acute Otitis Media | Trial comparisons |
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: Guideline-concordant Antibiotic Duration for Adults Hospitalized With Community Acquired Pneumonia | Trial comparisons |
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: Guideline-concordant Decision to Not Prescribe Antibiotics for Pediatric Acute Otitis Media | Trial comparisons |
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: Guideline-concordant Antibiotic Choice for Pediatric Community Acquired Pneumonia | Trial comparisons |
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: 28-day Community Acquired Pneumonia-related Outpatient Revisits (Emergency Department, Urgent Care, or Primary Care) in Children | Trial comparisons |
Pre-Intervention: Patients Diagnosed With Conditions of Interest During Study Period vs Post-Intervention: Patients Diagnosed With Conditions of Interest During Study Period: Guideline-concordant Antibiotic Use for Children With Community-acquired Pneumonia | Trial comparisons |
1 to 10 of 24
See all 24 trial comparisonsTests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06027593
GET https://conductscience.org/api/trials/v1/NCT06027593/registered?page=2