Trial · NCT06748040
Genetic Testing to Understand and Address Renal Disease Disparities Across the United States Pharmacogenetic Substudy
NCT06748040, Not applicable, Completed, Duke University; results first posted 2025-04-30
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Genetic Testing to Understand and Address Renal Disease Disparities Across the United States Pharmacogenetic Substudy. Trials, record NCT06748040. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT06748040
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Genetic Testing to Understand and Address Renal Disease Disparities Across the United States Pharmacogenetic Substudy
- NCT number
- NCT06748040
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 1,874 participants, actual
- Lead sponsor
- Duke University
- Conditions
- Chronic Kidney Disease, Hypertension
- Interventions
- Timing of return of results
- First posted
- 2024-12-24
- Last updated
- 2025-06-17
- Results first posted
- 2025-04-30
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Systolic Blood Pressure From Baseline to 3 Months for APOL1 Negative Participants | Baseline to 3 month study visit |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in Systolic Blood Pressure From Baseline to 3 Months for APOL1 Negative Participants | Baseline to 3 month study visit | Intent To Treat (ITT) population for PGx substudy. | mmHg | MEAN |
Source ClinicalTrials.gov
Results by group2
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change in Systolic Blood Pressure From Baseline to 3 Months for APOL1 Negative Participants | Immediate Return of Results | -3.7 | Standard Deviation 19.0 | mmHg | |
| Change in Systolic Blood Pressure From Baseline to 3 Months for APOL1 Negative Participants | Delayed Return of Results | -3.1 | Standard Deviation 19.0 | mmHg |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Immediate Return of Results | 953 | |
| Overall Study | STARTED | Delayed Return of Results | 921 | |
| Overall Study | COMPLETED | Immediate Return of Results | 813 | |
| Overall Study | COMPLETED | Delayed Return of Results | 780 | |
| Overall Study | NOT COMPLETED | Immediate Return of Results | 140 | |
| Overall Study | NOT COMPLETED | Delayed Return of Results | 141 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Immediate Return of Results | 3 | 953 |
| Total, all-cause mortality | Delayed Return of Results | 4 | 921 |
| Total, other adverse events | Immediate Return of Results | 0 | 0 |
| Total, other adverse events | Delayed Return of Results | 0 | 0 |
| Total, serious adverse events | Immediate Return of Results | 0 | 0 |
| Total, serious adverse events | Delayed Return of Results | 0 | 0 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 35660539 | BACKGROUND |
Source PubMed
Grants4
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| U01HG007269 | IGNITE EP2 - Admin Supplement | CAVALLARI, LARISA HUMMA; JOHNSON, JULIE A. | UNIVERSITY OF FLORIDA | NATIONAL HUMAN GENOME RESEARCH INSTITUTE | 2013 to 2024 | NIH RePORTER |
| U01HG010225 | The IGNITE II CC: Engagement, Coordination, Demonstration, and Dissemination | WYATT, CHRISTINA M; CHAKRABORTY, HRISHIKESH | DUKE UNIVERSITY | NATIONAL HUMAN GENOME RESEARCH INSTITUTE | 2018 to 2024 | NIH RePORTER |
| U01HG010245 | Implementing genomic medicine through pragmatic trials in diverse and underserved populations across Indiana. | SKAAR, TODD C.; DEXTER, PAUL | INDIANA UNIVERSITY INDIANAPOLIS | NATIONAL HUMAN GENOME RESEARCH INSTITUTE | 2018 to 2024 | NIH RePORTER |
| U01HG010248 | GeNYC: Genomic Implementation Research in the Diverse Settings and Populations of New York City | HOROWITZ, CAROL R | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | NATIONAL HUMAN GENOME RESEARCH INSTITUTE | 2018 to 2024 | NIH RePORTER |
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Immediate Return of Results vs Delayed Return of Results: deaths from any cause |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT06748040
GET https://conductscience.org/api/trials/v1/NCT06748040/registered