Trial · NCT07885540
Preoperative Pneumococcal and Influenza Vaccination to Prevent Postoperative Pulmonary Infection in Patients Undergoing Lung Resection for Pulmonary Nodules or Lung Cancer
NCT07885540, Phase 4, Not yet recruiting, The First Affiliated Hospital of Guangzhou Medical University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Preoperative Pneumococcal and Influenza Vaccination to Prevent Postoperative Pulmonary Infection in Patients Undergoing Lung Resection for Pulmonary Nodules or Lung Cancer. Trials, record NCT07885540. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07885540
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Preoperative Pneumococcal and Influenza Vaccination to Prevent Postoperative Pulmonary Infection in Patients Undergoing Lung Resection for Pulmonary Nodules or Lung Cancer
- NCT number
- NCT07885540
- Status
- Not yet recruiting
- Phases
- Phase 4
- Enrollment
- 1,278 participants, estimated
- Lead sponsor
- The First Affiliated Hospital of Guangzhou Medical University
- Conditions
- Pneumococcal Polysaccharide Vaccine, Influenza Vaccines, Preoperative, Lung Resection Surgery, Thoracic Surgery
- Interventions
- 23-valent pneumococcal polysaccharide vaccine, Quadrivalent split-virion influenza vaccine
- First posted
- 2026-10-21
- Last updated
- 2026-10-21
Source ClinicalTrials.gov
Registered outcomes16
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Proportion of participants with postoperative pulmonary infection within 30 days after surgery | From surgery to 30 days after surgery | Pulmonary infection defined by modified US CDC/NHSN criteria (new or progressive pulmonary infiltrate on imaging, at least 1 clinical sign and at least 2 respiratory signs), confirmed by an independent Endpoint Adjudication Committee blinded to group assignment. |
| Secondary | Proportion of participants with postoperative pulmonary infection within 90 days after surgery | From surgery to 90 days after surgery | Same definition and blinded adjudication as the primary outcome. |
| Secondary | Proportion of participants with postoperative pulmonary infection within 180 days after surgery | From surgery to 180 days after surgery | Same definition and blinded adjudication as the primary outcome. |
| Secondary | Incidence of severe pneumonia | Within 30, 90 and 180 days after surgery | Severe pneumonia defined as 1 major criterion (invasive mechanical ventilation; septic shock requiring vasopressors) or at least 3 minor criteria (respiratory rate 30/min or more; PaO2/FiO2 250 or less; multilobar infiltrates; confusion/disorientation; BUN 20 mg/dL or more; WBC below 4000/mm3 due to infection; platelets below 100,000/mm3; core temperature below 36 degrees C; hypotension requiring aggressive fluid resuscitation). |
| Secondary | Incidence of respiratory failure | Within 30, 90 and 180 days after surgery | Type I: PaO2 below 60 mmHg with normal or low PaCO2 (50 mmHg or less). Type II: PaO2 below 60 mmHg with PaCO2 above 50 mmHg. |
| Secondary | Incidence of Streptococcus pneumoniae infection | Within 30, 90 and 180 days after surgery | Any of: S. pneumoniae isolated from sputum, bronchoalveolar lavage fluid or blood culture; positive urinary pneumococcal antigen; or a 4-fold or greater rise in serum pneumococcal antibody titer between acute and convalescent samples. |
| Secondary | Incidence of influenza virus infection | Within 30, 90 and 180 days after surgery | Any of: positive influenza RT-PCR on nasopharyngeal swab, sputum or bronchoalveolar lavage fluid; positive rapid antigen test; positive viral culture; or positive influenza-specific IgM or a 4-fold or greater rise in IgG titer. |
| Secondary | Postoperative length of hospital stay | From end of surgery to hospital discharge, assessed up to 180 days | Number of days from leaving the operating room to hospital discharge. |
| Secondary | Rate of postoperative ICU admission | From surgery to hospital discharge, assessed up to 180 days | |
| Secondary | Length of ICU stay | From surgery to hospital discharge, assessed up to 180 days | Duration of ICU stay in hours. |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07885540
GET https://conductscience.org/api/trials/v1/NCT07885540/registered